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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Andrology
Andrology
Andrology

Andrology

Our Research

The Andrology group pursues basic, applied and clinical research in male reproductive health, medicine and biology. Andrology is literally the study of man (Greek andros, man). The medical and scientific discipline is defined as the study of male reproductive health, medicine and biology. Male Reproductive Health involves the overlapping domains of Fertility, Sexuality and Androgenisation which overlap with male general health especially with regard to androgen effects.

The Andrology group focuses on both the biological and clinical effects of androgens on male health, in particular men's reproductive and general health across all ages. Androgens (male hormones), the main one being testosterone, occur naturally in the body and play far-reaching roles in many body systems, particularly in male reproduction, fertility and sexuality. They exert important influence on most non-reproductive tissues especially the prostate, cardiovascular system, bone and the brain, throughout the entire male lifespan and may also influence women's health.

The Andrology group is a collaboration of the:

  • Andrology Laboratory at the ANZAC Research Institute where the focus is on the physiology and pharmacology of androgens in males and females, by undertaking research using experimental animal models and laboratory bench research.
  • Andrology Department of Concord Hospital, where patient and community centred research is carried out and translated into improvements in patient care.

The focus is on the therapeutic use of androgens such as to treat hormone deficiency states in adolescence and adulthood, in certain chronic diseases, for male contraception and for ageing men. In addition we also study the relatively widespread misuse/overuse and abuse of androgens for many wishful or harmful non-medical reasons as well as in sports doping.

Key Achievements

On-going Studies: Following is a summary of the Institute's current research projects.

  • Subcutaneous route of administration of androgen ester injections. L Turner, C Fennell, S Spasevska, G Singh, DJ Handelsman.
  • Randomised controlled trial of testosterone vs placebo to prevent diabetes (T4DM study). R Iyer, AJ Conway, V Jayadev.
  • Pharmacokinetics of testosterone via scrotal transdermal route. R Iyer, G Fraser, L Turner.
  • Randomised controlled trial of testosterone vs placebo with choice extension phase for androgen deficiency symptoms (T4DM study). G Fraser, R Iyer , L Turner, AJ Conway, V Jayadev , DJ Handelsman.
  • Randomised controlled trial of DHT pre-treatment for poor ovarian response in IVF. K Walters, N Narayana-Shankara, A Marren, M Bowman, DJ Handelsman.

Laboratory Research:

  • Steroid Mass Spectrometry: measuring steroids in serum and biological samples. R Desai, T Harwood, P Keski-Rahkonen, M Jimenez, K Walters, N Narayana-Shankara, DJ Handelsman.
  • Development and application of urine steroid and LH assays for field studies of puberty (Archer study). G Singh, R Desai, DJ Handelsman.

Experimental Studies of Androgen Action

  • Androgens and the Prostate. U Simanainen, F Suarez, K McNamara, DJ Handelsman.
  • Hormonal regulation of Sertoli cell function and spermatogenesis. R Hazra, D Upton, T Rastegar, L Corcoran, J Spaliviero, M Jimenez, DJ Handelsman, CM Allan.
  • Androgens, Ageing and Female Reproductive Physiology. K Walters, A Caldwell, D Upton, H Lin, CM Allan, DJ Handelsman.
  • Role of Androgens in the Breast and Uterus. U Simanainen, K Walters, P Choi, B Psarommatis, DJ Handelsman.

Public Health Andrology

  • Hormonal Epidemiology of Male Ageing: The Concord Health in Ageing Men Project (CHAMP). B Hsu, R Cumming, D Le Couteur, MJ Seibel, F Blyth, V Naganathan, DJ Handelsman and others.
  • Pharmacoepidemiology of testosterone prescribing and overuse. LP Ly, DJ Handelsman.
  • Androgen Abuse: Testosterone & Sports Doping. A Idan, C Fennell, M Jimenez, DJ Handelsman in collaboration with A Death, L McRobb, K McGrath (Heart Research Institute) and C Goebel, R Kazlausakas, G Trout, C Howe (National Measurement Institute).
  • Statistical methods to deduce population-based profile of androgen status in men and women over a life span. K Sikaris, LP Ly, DJ Handelsman.
  • Pooled Australian data on androgen status of men. B Yeap,G Wittert, LP Ly, DJ Handelsman.

Awards/Medals

  • Sydney Research Awards 2015 Supervisor Award - Dr Kirsty Walters
  • Society for Reproductive BiologyEmerging Research Leader Award 2015 - Dr Kirsty Walters
  • Life Member, Society of Reproductive Biology 2015 - Prof David Handelsman
  • Fellow, Australian Academy of Medical and Health Sciences 2015 - Prof David Handelsman

Research Staff

Group Leader:

  • Professor David Handelsman

Senior Scientists:

  • Dr Charles Allan
  • Ms Reena Desai
  • Dr Ulla Simanainen
  • Dr Kirsty Walters

Clinical Investigators:

  • Professor Ann Conway
  • Dr Veena Jayadev

Clinical Coordinators:

  • Glenda Fraser
  • Leo Turner
  • Sasha Savkovic
  • Carolyn Fennell

Clinical Co-investigators: 

  • Dr Rakesh Iyer
  • Dr Nandini Shankara-Narayana
  • Dr Shao Feng Mok

Scientists:

  • Reena Desai
  • Tim Harwood
  • Mark Jimenez
  • Frank Bathur
  • Fay Bacha
  • Irene Di Piero
  • Ljubica Andres
  • Gurmeet Singh
  • Ulla Simanainen
  • Danielle Upton
  • Jenny Spaliviero
  • Melissa Edwards
  • Charles Allan
  • Aimee Caldwell
  • Harry Lin
  • Peter Choi

Data Manager:

  • Lam Ly

Higher Degree Students:

PhD:

  • Gurmeet Singh
  • Peter Choi
  • Danielle Upton
  • Aimee Caldwell
  • Harry Lin
  • Ben Hsu

Masters:

  • Dr Rakesh Iyer
  • Dr Nandini Shankara-Narayana


Publications and Presentations

Publication Details:
  1. Hsu B, Hirani V, Naganathan V, Blyth FM, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG. Sexual Function and Mortality in Older Men: The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2016 Jun 1. PMID: 27252309.
  2. Handelsman DJ, Sikaris K, Ly LP. Estimating age-specific trends in circulating testosterone and sex hormone-binding globulin in males and females across the lifespan. Ann Clin Biochem. 2016 May;53(Pt 3):377-84. PMID: 26438522.
  3. Walters KA, Handelsman DJ. Androgen receptor splice variants and polycystic ovary syndrome: cause or effect? Asian J Androl. 2016 May-Jun;18(3):442-3. PMID: 26306851
  4. Choi JP, Zheng Y, Handelsman DJ, Simanainen U. Glandular epithelial AR inactivation enhances PTEN deletion-induced uterine pathology. Endocr Relat Cancer. 2016 May;23(5):377-90. PMID: 26984887.
  5. Hsu B, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Hirani V, Waite LM, Seibel MJ, Handelsman DJ. Temporal Changes in Androgens and Estrogens Are Associated With All-Cause and Cause-Specific Mortality in Older Men. J Clin Endocrinol Metab. 2016 May;101(5):2201-10. PMID: 26963953.
  6. Held FP, Blyth F, Gnjidic D, Hirani V, Naganathan V, Waite LM, Seibel MJ, Rollo J, Handelsman DJ, Cumming RG, Le Couteur DG. Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project. J Gerontol A Biol Sci Med Sci. 2016 May;71(5):625-31. PMID: 26508296.
  7. Chan YX, Knuiman MW, Hung J, Divitini ML, Beilby JP, Handelsman DJ, Beilin J, McQuillan B, Yeap BB. Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and non-fatal cardiovascular events, and mortality in men aged 17-97 years. Clin Endocrinol (Oxf). 2016 Apr 23. PMID: 27106765.
  8. Hsu B, Cumming RG, Hirani V, Blyth FM, Naganathan V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ. Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men. J Clin Endocrinol Metab. 2016 Apr;101(4):1836-46. PMID: 26918290.
  9. Sinclair M, Gow PJ, Angus PW, Hoermann R, Handelsman DJ, Wittert G, Martin S, Grossmann M. High circulating estrone and low testosterone correlate with adverse clinical outcomes in men with advanced liver disease. Liver Int. 2016 Mar 21. PMID: 26998685.
  10. Hirani V, Naganathan V, Blyth F, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Hsu B, Cumming RG. Low Hemoglobin Concentrations Are Associated With Sarcopenia, Physical Performance, and Disability in Older Australian Men in Cross-sectional and Longitudinal Analysis: The Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2016 PMID: 26994391.
  11. Noguchi N, Blyth FM, Waite LM, Naganathan V, Cumming RG, Handelsman DJ, Seibel MJ, Le Couteur DG. Prevalence of the geriatric syndromes and frailty in older men living in the community: The Concord Health and Ageing in Men Project. Australas J Ageing. 2016 Mar 11. PMID: 26970062.
  12. Yeap BB, Knuiman MW, Divitini ML, Hui J, Arscott GM, Handelsman DJ, McLennan SV, Twigg SM, McQuillan B, Hung J, Beilby JP. Epidemiological and Mendelian Randomization Studies of Dihydrotestosterone and Estradiol and Leukocyte Telomere Length in Men. J Clin Endocrinol Metab. 2016 Mar;101(3):1299-306. PMID: 26789780.
  13. Handelsman DJ, Matsumoto AM, Gerrard DF. Doping Status of DHEA Treatment for Female Athletes with Adrenal Insufficiency. Clin J Sport Med. 2016 PMID: 26844622.
  14. Ford AH, Yeap BB, Flicker L, Hankey GJ, Chubb SA, Handelsman DJ, Golledge J, Almeida OP. Prospective longitudinal study of testosterone and incident depression in older men: The Health In Men Study. Psychoneuroendocrinology. 2016 Feb;64:57-65. PMID: 26615472.
  15. Noguchi N, Chan L, Cumming RG, Blyth FM, Handelsman DJ, Waite LM, Le Couteur DG, Naganathan V. Natural history of non-neurogenic overactive bladder and urinary incontinence over 5 years in community-dwelling older men: The Concord Health And Aging in Men Project. Neurourol Urodyn. 2016 Jan 12. PMID: 26756291.
  16. Jamsen KM, Bell JS, Hilmer SN, Kirkpatrick CM, Ilomäki J, Le Couteur D, Blyth FM, Handelsman DJ, Waite L, Naganathan V, Cumming RG, Gnjidic D. Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions Between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. J Am Geriatr Soc. 2016 Jan;64(1):89-95. PMID: 26782856.
  17. Handelsman DJ, Yeap B, Flicker L, Martin S, Wittert GA, Ly LP. Age-specific population centiles for androgen status in men. Eur J Endocrinol. 2015 Dec;173(6):809-17. PMID: 26385186.
  18. Hart RJ, Doherty DA, McLachlan RI, Walls ML, Keelan JA, Dickinson JE, Skakkebaek NE, Norman RJ, Handelsman DJ. Testicular function in a birth cohort of young men. Hum Reprod. 2015 Dec;30(12):2713-24. PMID: 26409015.
  19. Singh GK, Balzer BW, Desai R, Jimenez M, Steinbeck KS, Handelsman DJ. Requirement for specific gravity and creatinine adjustments for urinary steroids and luteinizing hormone concentrations in adolescents. Ann Clin Biochem. 2015 Nov;52(Pt 6):665-71. PMID: 25780247.
  20. Choi JP, Zheng Y, Skulte KA, Handelsman DJ, Simanainen U. Development and Characterization of Uterine Glandular Epithelium Specific Androgen Receptor Knockout Mouse Model. Biol Reprod. 2015 Nov;93(5):120. PMID: 26468082.
  21. Purves-Tyson TD, Allen K, Fung S, Rothmond D, Noble PL, Handelsman DJ, Shannon Weickert C. Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex. Schizophr Res. 2015 Nov;168(3):661-70. PMID: 26088421.
  22. Whitehouse AJ, Gilani SZ, Shafait F, Mian A, Tan DW, Maybery MT, Keelan JA, Hart R, Handelsman DJ, Goonawardene M, Eastwood P. Prenatal testosterone exposure is related to sexually dimorphic facial morphology in adulthood. Proc Biol Sci. 2015 Oct ;282(1816):20151351. PMID: 26400740
  23. Choi JP, Desai R, Zheng Y, Yao M, Dong Q, Watson G, Handelsman DJ, Simanainen U. Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer. Endocr Relat Cancer. 2015 Oct;22(5):687-701. PMID: 26285813.
  24. Hsu B, Cumming RG, Seibel MJ, Naganathan V, Blyth FM, Bleicher K, Dave A, Le Couteur DG, Waite LM, Handelsman DJ. Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project. J Bone Miner Res. 2015 Sep;30(9):1701-8. PMID: 25736139.
  25. Handelsman DJ. Irrational Exuberance in Testosterone Prescribing: When Will the Bubble Burst? Med Care. 2015 Sep;53(9):743-5. PMID: 26270825.
  26. Mohan SS, Knuiman MW, Divitini ML, James AL, Musk AW, Handelsman DJ, Beilin J, Hunter M, Yeap BB. Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men. Clin Endocrinol (Oxf). 2015 Aug;83(2):268-76. PMID: 25660119.
  27. Upton DH, Fuller ES, Colvin EK, Walters KA, Jimenez M, Desai R, Handelsman DJ, Howell VM, Allan CM. Granulosa Cell-Specific Brca1 Loss Alone or Combined with Trp53 Haploinsufficiency and Transgenic FSH Expression Fails to Induce Ovarian Tumors. Horm Cancer. 2015 Aug;6(4):142-52. PMID: 25943777.
  28. Keski-Rahkonen P, Desai R, Jimenez M, Harwood DT, Handelsman DJ. Measurement of Estradiol in Human Serum by LC-MS/MS Using a Novel Estrogen-Specific Derivatization Reagent. Anal Chem. 2015 Jul 21;87(14):7180-6. PubMed PMID: 26090565.
  29. Hirani V, Naganathan V, Blyth F, Le Couteur DG, Kelly P, Handelsman DJ, Waite LM, Cumming RG. Cross-Sectional and Longitudinal Associations Between Anemia and Frailty in Older Australian Men: The Concord Health and Aging in Men Project. J Am Med Dir Assoc. 2015 Jul 1;16(7):614-20. PMID: 25840760.
  30. Hirani V, Blyth F, Naganathan V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG. Sarcopenia Is Associated With Incident Disability, Institutionalization, and Mortality in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. J Am Med Dir Assoc. 2015 Jul 1;16(7):607-13. PMID: 25820131.
  31. Hsu B, Cumming RG, Waite LM, Blyth FM, Naganathan V, Le Couteur DG, Seibel MJ, Handelsman DJ. Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. J Clin Endocrinol Metab. 2015 Jun;100(6):2223-30. PMID: 25867811.
  32. Middleton T, Turner L, Fennell C, Savkovic S, Jayadev V, Conway AJ, Handelsman DJ. Complications of injectable testosterone undecanoate in routine clinical practice. Eur J Endocrinol. 2015 May;172(5):511-7. PMID: 25637074.
  33. Caldwell AS, Eid S, Kay CR, Jimenez M, McMahon AC, Desai R, Allan CM, Smith JT, Handelsman DJ, Walters KA. Haplosufficient genomic androgen receptor signaling is adequate to protect female mice from induction of polycystic ovary syndrome features by prenatal hyperandrogenization. Endocrinology. 2015 Apr;156(4):1441-52. PMID: 25643156.
  34. Purves-Tyson TD, Boerrigter D, Allen K, Zavitsanou K, Karl T, Djunaidi V, Double KL, Desai R, Handelsman DJ, Weickert CS. Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats. Horm Behav. 2015 Apr;70:73-84. PMID: 25747465.
  35. Perls T, Handelsman DJ. Disease mongering of age-associated declines in testosterone and growth hormone levels. J Am Geriatr Soc. 2015 Apr;63(4):809-11. PMID: 25809947.
  36. Hsu B, Cumming RG, Blyth FM, Naganathan V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ. The longitudinal relationship of sexual function and androgen status in older men: the Concord Health and Ageing in Men Project. J Clin Endocrinol Metab. 2015 Apr;100(4):1350-8. PMID: 25629357.
  37. Solon-Biet SM, Walters KA, Simanainen UK, McMahon AC, Ruohonen K, Ballard JW, Raubenheimer D, Handelsman DJ, Le Couteur DG, Simpson SJ. Macronutrient balance, reproductive function, and lifespan in aging mice. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3481-6. PMID: 25733862
  38. Hirani V, Blyth FM, Naganathan V, Cumming RG, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ. Active vitamin D (1,25 dihydroxyvitamin D) is associated with chronic pain in older Australian men: the Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):387-95. PMID: 25104821.
  39. Hirani V, Cumming RG, Blyth F, Naganathan V, Le Couteur DG, Waite LM, Handelsman DJ, Seibel MJ. Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: the Concord Health and Ageing in Men Project. Age (Dordr). 2015 Feb;37(1):9749. PMID: 25649710
  40. Simanainen U, Ryan T, Li D, Suarez FG, Gao YR, Watson G, Wang Y, Handelsman DJ. Androgen receptor actions modify skin structure and chemical carcinogen-induced skin cancer susceptibility in mice. Horm Cancer. 2015 Feb;6(1):45-53. PMID: 25563841.
  41. Chan YX, Knuiman MW, Hung J, Divitini ML, Handelsman DJ, Beilby JP, McQuillan B, Yeap BB. Testosterone, dihydrotestosterone and estradiol are differentially associated with carotid intima-media thickness and the presence of carotid plaque in men with and without coronary artery disease. Endocr J. 2015;62(9):777-86. PMID: 26073868.
  42. Handelsman DJ, Jimenez M, Singh GK, Spaliviero J, Desai R, Walters KA. Measurement of testosterone by immunoassays and mass spectrometry in mouse serum, testicular, and ovarian extracts. Endocrinology. 2015 Jan;156(1):400-5. PMID: 25365769.
  43. Yeap BB, Alfonso H, Chubb SA, Gauci R, Byrnes E, Beilby JP, Ebeling PR, Handelsman DJ, Allan CA, Grossmann M, Norman PE, Flicker L. Higher serum undercarboxylated osteocalcin and other bone turnover markers are associated with reduced diabetes risk and lower estradiol concentrations in older men. J Clin Endocrinol Metab. 2015 Jan;100(1):63-71. PMID: 25365314.
  44. 44: Singh GK, Balzer BW, Kelly PJ, Paxton K, Hawke CI, Handelsman DJ, Steinbeck KS. Urinary Sex Steroids and Anthropometric Markers of Puberty - A Novel Approach to Characterising Within-Person Changes of Puberty Hormones. PLoS One. 2015 Nov 23;10(11):e0143555. PMID: 26599397

Book Chapters:
  1. Handelsman DJ. Performance Enhancing Hormone Doping in Sport. 2015 May 19. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext [Internet].

Presentations:

National and International:

  1. Chan YX, Knuiman MW, Hung J, Divitini ML, Handelsman DJ, Beliby JP, McQuillan B, Yeap BB. Testosterone, dihydrotestosterone and estradiol are differentially associated with carotid intima-media thickness and the presence of carotid atheroma in men with and without coronary artery disease. Proceedings of the 97th Annual Scientific Meeting, US Endocrine Society, San Diego, March 2015
  2. Upton DH, Fuller ES, Colvin EK, Walters K, Jimenez M, Handelsman DJ, Howell VM, Allan CM. Granulosa cell-specific Brca1 loss alone or combined with Trp53 haploinsufficiency and transgenic FSH expression fails to induce ovarian tumors. Proceedings of the Society for the Study of Reproduction, San Juan, Puerto Rico, USA, June 2015
  3. Caldwell ASL, Lin D (Harry), Allan CM, Handelsman DJ, Walters KA. Aberrant follicle growth in cultured ovarian follicles from a DHT-induced Polycystic Ovary Syndrome (PCOS) mouse model. Proceedings of the Society for the Study of Reproduction, San Juan, Puerto Rico, USA, June 2015
  4. Cumming RG, Hsu B, Naganathan V, Blyth F, Handelsman DJ. Low levels of testosterone are not a cause of poor health in older men: results from the Concord Health and Ageing in Men Project. Australian and New Zealand Society for Geriatric Medicine, Perth, May 2015
  5. Cumming RG, Hsu B, Naganathan V, Blyth F, Handelsman DJ. Low levels of testosterone are not a cause of poor health in older men: results from the Concord Health and Ageing in Men Project. Asia-Pacific International Association of Gerontology and Geriatrics meeting, Chaing Mai, Thailand, October 2015
  6. Cho D, McGregor N, Tonkin B, Brennan H, Johnson R, Zebaze R, Handelsman DJ, Martin TJ, Sims N. Osteocytic JAK/STAT signalling controls corticalization of long bones by estradiol and testosterone-dependent mechanisms. American Society for Bone and Mineral Metabolism scientific meeting, Seattle, October 2015.
  7. Caldwell ASL, Lin D, Allan CM, Handelsman DJ, Walters KA. Adverse effects of the hyperandrogenic environment on follicle dynamics in culture: a model of Polycystic Ovary Syndrome (PCOS). Proceedings of the Annual Scientific Meeting of the Society for Reproductive Biology, Adelaide, August 2015
  8. Shankara Narayana N, Walters KA, Zawada S, Bonifacio M, Marren A, Handelsman DJ. Accuracy of direct progesterone immunoassay vs liquid chromatography mass spectrometry. Proceedings of the Annual Scientific Meeting Endocrine Society of Australia, Adelaide, August 2015
  9. Hsu B, Cumming RG, Naganathan V, Blyth FM, Handelsman DJ. Lower circulating testosterone (T) is a consequence rather than a cause of poor health in older men: the Concord Health and Ageing in Men Project (CHAMP). Proceedings of the Annual Scientific Meeting Endocrine Society of Australia, Adelaide, August 2015
  10. Chan YX, Knuiman MW, Hung J, Divitni ML, Beilby JP, Handelsman DJ, Beilin J, McQuillan B, Yeap BB. Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and non-fatal cardiovascular events, and mortality in men aged 17-97 years. Proceedings of the Annual Scientific Meeting Endocrine Society of Australia, Adelaide, August 2015
  11. Upton DH, Walters KA, Handelsman DJ, Holt J, Allan CM. High FSH levels alter oocyte in vitro maturation but not oocyte aneuploidy in a transgenic mouse model. Proceedings of the Annual Scientific Meeting Endocrine Society of Australia, Adelaide, August 2015
  12. Cho DC, McGregor N, Tonkin B, Brennan H, Johnson R, Zebaze R, Handelsman DJ, Martin TJ, Sims NA. Osteocytic JAK/STAT signalling controls corticalisation by estradiol and testosterone-dependent mechanisms. Proceedings of the Annual Scientific Meeting Australia and New Zealand Bone and Mineral Society, Hobart, November 2015
  13. Upton DH, Walters KA, Jimenez M, Handelsman DJ, Allan CM. Granulosa cell-specific or global Pten mutations in combination with transgenic FSH expression fails to induce ovarian tumors. Proceedings of the 29th International Mammalian Genome Conference, Yokohama, Japan, Nov 2015

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE Total ($) Years
NHMRC Teede, Norman, Hart, Handelsman, Davies,Sullivan, McNeil, Moran, Rodgers, Patton Centre for Research Excellence in the evaluation, management and health care needs of Polycystic Ovary $2,489,052 2015-2019
National Institute of Health Le Couteur, Handelsman, Simpson (CPC), Milne, Cooper Nutrition, ageing and health $130,000 2015
ARI Bridging Scheme Allan, Handelsman Testicular development and male fertility: understanding vital androgen actions $60,000 2016
NHMRC Handelsman (AI) SHOW Study (assays circulating sex steroid levels by tandem liquid chromatography mass spectrometry) $532,000 2016-2017
NHMRC WaltersHandelsman, Allan Role of androgens in polycystic ovary syndrome $494,000 2012-2015
NHMRC Wittert, Yeap, Grossman,Conway, Allan, Kaye, Jenkins, Daniel. Testosterone intervention for the prevention of diabetes mellitus in high risk men: a randomised trial $4,800,000 2012-2016
University of Sydney/ARI Bridging Scheme Simanainen, Handelsman, Zheng Androgen signalling as a therapeutic target in breast cancer $60,000 2013-2015
University of Sydney/ARI Bridging Scheme Allan, Handelsman Dissecting the somatic control of hormone-regulated spermatogenic development $60,000 2013-2015
Andrology Australia Marren Andrology Australia Training Fellowship $15,000 2013-2014
University of Sydney/ARI Bridging Scheme Allan, Walters FSH control of follicle and oocyte development $60,000 2014-2016
ARI Bridging Scheme Walters, Smith, Handelsman, Allan Androgen receptor mediated regulation of female reproduction $60,000 2014-2016
Besins Healthcare Handelsman, Fraser, Turner, Jayedev, Conway Testosterone for Androgen Deficiency-like sympotoms (T4ADS): a three phase, placebo-controlled, double-blind Crossover study $100,000 2014-2016

Contact details for department

Head of Department: Professor David Handelsman

Department/Unit: Andrology
Address:
Concord Hospital
Hospital Road
Concord NSW 2139
Telephone: (02) 9767 7222
Facsimile: (02) 9767 7221
Web: http://www.slhd.nsw.gov.au/research/
Email: djh@anzac.edu.au