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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Centre for Education and Research on Ageing (CERA)

Our Research

The Mission Statements and Objectives of the Centre for Education and Research on Ageing (CERA) are:

  • To improve the health and productivity of older people through research into the ageing process.
  • To improve the well-being and quality of life of older people, especially those with frailty or dementia, through research into health care.
  • To provide leadership in the education and training of people involved in the care of older people and involved in ageing research.

Through innovative and multidisciplinary research, CERA aims to expand and share knowledge of human ageing, so that the health and quality of life of older people can be improved. Currently, its broad research strengths are focussed on therapeutics in old age, geriatric syndromes (falls, frailty, multimorbidity, cognitive impairment) and the biology of ageing.

Our ageing research is achieved through a broad program that incorporates clinical, laboratory, epidemiological and health service evaluation approaches. Allied to this are education programs, at basic and advanced levels of practice, in geriatric medicine and other education programs for medical students and aged care workers from a range of professional settings including pharmacy, oral health, nursing and allied health. The teaching of geriatric medicine and associated disciplines within The University of Sydney's, Sydney Medical School continues to be one of CERA's core programs.

CERA has a complex and flexible structure that reflects its position within the University and the Concord Hospital. CERA was formed in 1997 as a joint centre between the University of Sydney and Concord Hospital. CERA was subsequently formalized as a Centre of the University of Sydney in 2009. CERA has strong linkages with the Sydney Local Health District, being a member of Sydney Research and the Ageing and Alzheimers Institute (AAAI) of the Concord Hospital. The members of CERA include clinical academics, university academics, researchers employed on competitive grant funding and hospital doctors, nurses and allied health professionals who are involved with ageing research at Concord Hospital.

Key Achievements

The main academics affiliated with CERA (Le Couteur, McLachlan, Wright, Blyth, Naganathan and Cogger) have published more than 310 peer reviewed journal articles (2010-2016) including leading journals such as British Medical Journal, Cell, Cell Metabolism, Lancet, Proceedings of the National Academy of Science, Nature Reviews in Drug Discovery and JAMA Internal Medicine.

CERA has contributed to 17 book chapters since 2010, including a chapters in the World's leading textbooks on internal medicine, liver pathophysiology, and geriatric pharmacology (Harrisons Principles of Internal Medicine; The Liver: Biology and Pathobiology; and The Oxford Textbook of Geriatric Medicine). CERA has raised over $13 million in competitive category 1 NHMRC and ARC grants (2010-continuing) and substantial funding for other granting bodies. Academics with CERA have supervised 16 postgraduate students to completion, with another 23 students currently enrolled in PhD studies. Our academics have held major roles with the University, including Associate Dean and Head of the Concord Clinical School, Postgraduate Supervisors and Associate Deans (research) at Concord Clinical School and in the Faculty of Pharmacy, while providing coal face teaching in medicine, pharmacy and oral health.

Awards/Medals

  • 2016 Officer (AO) in the General Division of the Order of Australia awarded to Professor David Le Couteur for distinguished service to medicine as a clinical pharmacologist and geriatrician, particularly through a range of advisory roles and academic research activities.
  • 2015 Member (AM) in the General Division of the Order of Australia awarded to Professor Wright for services to dentistry particular in the area of population oral health.
  • 2015 Rand Medal, awarded to Professor Le Couteur for outstanding contribution to pharmacology (Australasian Society for Clinical and Experimental Pharmacology).

Research Staff

Director, Professor David Le Couteur AO.

David Le Couteur is Professor of Geriatric Medicine at the University of Sydney and Senior Staff Specialist Physician in Geriatric Medicine at the Concord RG Hospital in Sydney. His research focusses on ageing biology and geriatric pharmacology. Academic metrics include more than 290 publications and chapters with more than 12,000 citations; scholar H index 51, 21 Australian NHMRC and ARC research grants (>$12 million funding over 22 yrs) and 32 post-graduate research students (16 completed PhD, 6 current PhD). He was president of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT 2011-2013). He was recipient of the American Society for Clinical Pharmacology and Therapeutics 2013 William B Abrams award (contribution to geriatric clinical pharmacology) and the 2015 Rand Medal of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (contribution to national and international pharmacology). He served on several Federal medicines committees: Pharmaceutical Benefits Advisory Committee (2009-2013) and chaired its Drug Utilization Subcommittee; Australian Drug Evaluation Committee (1998-2005) and chaired its Pharmaceutical Subcommittee; and Advisory Committee on the Safety of Medicines (2013-2014). In 2016 he was awarded an AO for for distinguished service to medicine as a clinical pharmacologist and geriatrician, particularly through a range of advisory roles and academic research activities.

Professor Andrew McLachlan.

Andrew McLachlan is a pharmacist and researcher with experience in clinical and experimental pharmacology and research into the quality use of medicines. He achieved First Class Honours and was awarded the University Medal during his undergraduate degree, completed a PhD in Sydney and then worked as a Postdoctoral researcher at the University of Manchester. In 1994 Andrew returned to Australia to take up a competitively funded postdoctoral fellowship in Clinical Pharmacology and Toxicology at St Vincent's Hospital (Sydney) before returning to the University of Sydney as a Lecturer in 1996. In 2006 he was appointed Professor of Pharmacy (Aged Care) in the Faculty of Pharmacy at the University of Sydney based at Concord Hospital and the Centre for Education and Research on Ageing (CERA) at Concord Hospital. His main research interests centre on understanding the causes and consequences of variability in response to medicines and how this informs their quality use. The focus of his research has been in special patient populations such as older people. Andrew is currently the Program Director of a NHMRC Centre for Research Excellence in Medicines and Ageing. Andrew has authored more than 200 research papers in peer reviewed journals and attracted over $12 M in competitive research funding. Andrew's particular expertise has meant he has been engaged in numerous research-based collaborations, acted as a consultant to the pharmaceutical industry, international universities, served on the Editorial Boards of international peer reviewed journals and been appointed to expert committees of Australian governments.

Associate Professor Victoria Cogger.

Victoria Cogger is an Associate Professor at Sydney Medical School, University of Sydney. She holds a BSc (Hons) and PhD from the University of Sydney and undertook Postdoctoral training at the National Institutes of Health in the USA with Professor Irwin Arias and Dr Jennifer Lippincott-Schwarz. She has over 60 peer-reviewed and 10 chapters and has been a chief investigator on 11 Australian NHMRC grants (~$4.5 million). Victoria's research focuses on ageing biology, understanding the function of the ageing liver and how structural and biological processes contribute to changing liver function with age. Victoria is the President elect of International Society of Hepatic Sinusoid research and received the Denis Wade and Johnson and Johnson New Investigator Award for the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists in 2006. Victoria has been Sub Dean of postgraduate research at Concord Clinical School of Sydney Medical School since 2007, overseeing the successful completion of Masters and Doctoral Students on that campus.

Professor Fiona Blyth.

Fiona Blyth is Head Concord Clinical School; Associate Dean, University of Sydney; Professor of Public Health and Pain Medicine; Visiting Professor, Arthritis Research UK Primary Care Centre, Keele University, UK; and Senior Advisor, Knowledge Exchange Program, The Sax Institute. Professor Blyth is an internationally renowned pain epidemiologist and is an editor two major journals in the field, Pain, and the European Journal of Pain. She is a member of the Global Burden of Disease consortium that has led to many major publications in the Lancet. She has published over 100 publications with over 6000 citations. As well as her contributions to epidemiological research into pain and ageing, Professor Blyth is also Associate Dean of the Concord Clinical School and is responsible for implementation of the medical graduate programme on this campus.

Professor Clive Wright.

Clive Wright is Associate Director (Oral Health) and Clinical Professor at the Centre for Education and Research on Ageing. He is Emeritus Professor, Preventive Dentistry and Community Dentistry at the University of Melbourne and holds adjunct Professorships with Charles Sturt University and the University of Newcastle. He was Chair of the Ministerial Review of Dental Services in Victoria in 1986, the inaugural Chair of the Accreditation Committee of Australian Dental Schools of the Australian Dental Council 1995/1996 and the Chair of the Dental Auxiliary Accreditation Sub-committee of the Australian Dental Council 2001/2002. He has served on the Australian Government Department of Health and Ageing Review of the Dental Benefits Act 2008, and currently serves on the NH&MRC Review of water fluoridation Committee and the Australian Dental Association (Inc)/ Alzheimer's Australia Professional Development Steering Committee. He was appointed by the Federal Minister for Health in 2012 to Chair the National Oral Health Promotion Planning Committee (2012-2013). He has more than 120 publications on oral health promotion, preventive dentistry, dental public health and geriatric dentistry. In 2000 he was awarded the Alan Docking Prize for Dental Research by the ANZ Division of the International Association for Dental Research, and two research papers on which he was co-author have received the Australian Dental Association Award for Excellence in Dental Journalism. In 2011 Clive was awarded the PHAA NSW Branch Public Health Impact Award and an Order of Australia (AM) Member in the General Division, in June 2015. He is a Chief Investigator with the current NH&MRC CHAMP research in oral health and co-supervises 6 post-graduate (MPhil & PhD) students.

Associate Professor Vasikaran Naganathan.

Vasi Naganathan is an academic at the University of Sydney and a consultant Geriatrician at Concord RG Hospital. His research interests are wide including: health of older men, oral health, falls, fractures and osteoporosis, pharmacology in the older people and the application of evidence-based medicine to older people. He is currently primary supervisor of 6 PhD students. Vasi has approximately 100 publications and has authored more than 50 research publications in the last 5 years. Vasi has bravely ventured into difficult area of clinical trials in older people. He is a lead investigator on a landmark NHMRC funded clinical trial to evaluate the efficacy of deprescribing medications in older people who live in residential aged care facilities. Vasi has developed research collaborations with a number of different disciplines including oncology, cardiology, pharmacy, nutrition and public health. He has trained many local geriatricians as Advanced Trainee Coordinator in the past (RACP award for excellence in mentoring). He has supervised a number of clinical research projects undertaken by trainees in Geriatric medicine, undergraduate medical students, dieticians and pharmacy students. Vasi is a Chair of Scientific Subcommittee of Australian and New Zealand Society of Geriatric medicine, member of the hospital's ethics committee (HREC) and Chair of the Scientific Subcommittee of the HREC, organising committee of 3 National ANZSGM scientific meetings and Member Scientific Advisory Committee of Osteoporosis Australia. He has developed an interest in the global health of older people and spent some time in Uganda (2010). He is and has collaborated on research projects in Uganda, Malaysia, and Thailand.

Administrative support

  • Ms Marisa Wright
  • Ms Janet Gilchrist

 Affiliated geriatricians

All of the Geriatric Medicine and Rehabilitation specialist physicians within Aged Care and Rehabilitation at Concord Hospital are affiliate members of CERA. The following specialists have been involved in research or enrolled in higher research degrees at the University of Sydney.

  • Dr Louise Waite PhD (Chief Investigator CHAMP)
  • Dr Helen Creasey (Chief Investigator, CHAMP)
  • Dr Nicola Boyle (PhD student)
  • Dr Eric Diu (clinical research)
  • Dr Lisa Ng (research student)
  • Dr Jennifer McMeniman (research student)
  • Dr John Cullen (health service research, Director Aged Care and Rehabilitation)

Biology

  • Dr Alessandra Warren (post doctoral scientist, Biogerontology)
  • Mr Glen Lockwood (research assistant, Biogerontology)
  • Dr Samantha Solon-Biet (post doctoral scientist, Charles Perkins Centre)
  • Dr Jibran Wali (post doctoral scientist, Charles Perkins Centre)

CHAMP

  • Dr Benjamin Hsu (post doctoral scientist)
  • Dr Vasant Hirani (post doctoral scientist)
  • Ms Kate Milledge (dietician, project officer)
  • Ms Janet Gilchrist (administrative assistant)

Clinical Research

  • Ms Leanne Kearney (research nurse)

Oral Health

  • Mr Gary Law
  • Mr Stephen Chu
  • Ms Sandra Taylor

Pharmacy

  • Monika Dzidowska, Research Program Manager, NHMRC CRE Medicines and Ageing

Higher Degree Students:

PhD:

  • Benjamin Hsu
  • Noran Hairi
  • Shajjia Razi
  • Rahul Gokarn
  • Alice Kane
  • Mashani Mohamed
  • Peter Cao
  • Devin Wahl
  • Rosilene Waern
  • Naomi Noguchi
  • Shane Eagles
  • Bei-Lun Li
  • Fatima Sakeena Hameem
  • Bhagwant Sekhon
  • Daniel Rifkin
  • Atheer Nassir
  • Alan Deutsch
  • George Johnson
  • Joanne Mohammadi
  • Sarah Aitken


Publications and Presentations

Publication Details:
  1. Simpson, S.J., D.G. Le Couteur, and D. Raubenheimer, Putting the balance back in diet. Cell, 2015. 161(1): p. 18-23.
  2. Solon-Biet, S.M., K.A. Walters, U.K. Simanainen, A.C. McMahon, K. Ruohonen, J.W. Ballard, D. Raubenheimer, D.J. Handelsman, D.G. Le Couteur, and S.J. Simpson, Macronutrient balance, reproductive function, and lifespan in aging mice. Proc Natl Acad Sci U S A, 2015. 112(11): p. 3481-6.
  3. Solon-Biet, S.M., S.J. Mitchell, R. de Cabo, D. Raubenheimer, D.G. Le Couteur, and S.J. Simpson, Macronutrients and caloric intake in health and longevity. J Endocrinol, 2015. 226(1): p. R17-28.
  4. Solon-Biet, S.M., S.J. Mitchell, S.C. Coogan, V.C. Cogger, R. Gokarn, A.C. McMahon, D. Raubenheimer, R. de Cabo, S.J. Simpson, and D.G. Le Couteur, Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice. Cell Rep, 2015. 11(10): p. 1529-34.
  5. Sierro, F., S.S. Tay, A. Warren, D.G. Le Couteur, G.W. McCaughan, D.G. Bowen, and P. Bertolino, Suicidal emperipolesis: a process leading to cell-in-cell structures, T cell clearance and immune homeostasis. Curr Mol Med, 2015. 15(9): p. 819-27.
  6. Scott, I.A. and D.G. Le Couteur, Physicians need to take the lead in deprescribing. Intern Med J, 2015. 45(3): p. 352-6.
  7. Scott, I.A., S.N. Hilmer, E. Reeve, K. Potter, D. Le Couteur, D. Rigby, D. Gnjidic, C.B. Del Mar, E.E. Roughead, A. Page, J. Jansen, and J.H. Martin, Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med, 2015. 175(5): p. 827-34.
  8. Waern, R.V., R.G. Cumming, F. Blyth, V. Naganathan, M. Allman-Farinelli, D. Le Couteur, S.J. Simpson, H. Kendig, and V. Hirani, Adequacy of nutritional intake among older men living in Sydney, Australia: findings from the Concord Health and Ageing in Men Project (CHAMP). Br J Nutr, 2015. 114(5): p. 812-21.
  9. Tran, B., M.O. Falster, K. Douglas, F. Blyth, and L.R. Jorm, Smoking and potentially preventable hospitalisation: the benefit of smoking cessation in older ages. Drug Alcohol Depend, 2015. 150: p. 85-91.
  10. Stevens, M.L., D. Steffens, M.L. Ferreira, J. Latimer, Q. Li, F. Blyth, and C.G. Maher, Patients and Physiotherapists Views on Triggers for Low Back Pain. Spine (Phila Pa 1976), 2015.
  11. Steffens, D., M.L. Ferreira, J. Latimer, P.H. Ferreira, B.W. Koes, F. Blyth, Q. Li, and C.G. Maher, What triggers an episode of acute low back pain? A case-crossover study. Arthritis Care Res (Hoboken), 2015. 67(3): p. 403-10.
  12. Yata, M., A.J. McLachlan, D.J. Foster, S.W. Page, and N.J. Beijerink, Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs. J Vet Pharmacol Ther, 2015.
  13. Walpola, R.L., R.A. Fois, A.J. McLachlan, and T.F. Chen, Evaluating the effectiveness of a peer-led education intervention to improve the patient safety attitudes of junior pharmacy students: a cross-sectional study using a latent growth curve modelling approach. BMJ Open, 2015. 5(12): p. e010045.
  14. Walpola, R.L., R.A. Fois, S.R. Carter, A.J. McLachlan, and T.F. Chen, Validation of a survey tool to assess the patient safety attitudes of pharmacy students. BMJ Open, 2015. 5(9): p. e008442.
  15. Rzewuska, M., M. Ferreira, A.J. McLachlan, G.C. Machado, and C.G. Maher, The efficacy of conservative treatment of osteoporotic compression fractures on acute pain relief: a systematic review with meta-analysis. Eur Spine J, 2015. 24(4): p. 702-14.
  16. Rosilene, W.V., R. Cumming, T. Travison, F. Blyth, V. Naganathan, M. Allman-Farinelli, and V. Hirani, Relative Validity of a Diet History Questionnaire Against a Four-Day Weighed Food Record among Older Men in Australia: The Concord Health and Ageing in Men Project (CHAMP). J Nutr Health Aging, 2015. 19(6): p. 603-10.
  17. Rice, A.S., B.H. Smith, and F.M. Blyth, Pain and the Global Burden of Disease. Pain, 2015.
  18. Redman, S., T. Turner, H. Davies, A. Williamson, A. Haynes, S. Brennan, A. Milat, D. O'Connor, F. Blyth, L. Jorm, and S. Green, The SPIRIT Action Framework: A structured approach to selecting and testing strategies to increase the use of research in policy. Soc Sci Med, 2015. 136-137: p. 147-55.
  19. Pont, L.G., J.T. Nielen, A.J. McLachlan, D. Gnjidic, L. Chan, R.G. Cumming, and K. Taxis, Measuring anticholinergic drug exposure in older community-dwelling Australian men: a comparison of four different measures. Br J Clin Pharmacol, 2015. 80(5): p. 1169-75.
  20. Piantadosi, C., I.M. Chapman, V. Naganathan, P. Hunter, I.D. Cameron, and R. Visvanathan, Recruiting older people at nutritional risk for clinical trials: what have we learned? BMC Res Notes, 2015. 8: p. 151.
  21. Parreira Pdo, C., C.G. Maher, J. Latimer, D. Steffens, F. Blyth, Q. Li, and M.L. Ferreira, Can patients identify what triggers their back pain? Secondary analysis of a case-crossover study. Pain, 2015. 156(10): p. 1913-9.
  22. Nicholas, M.K. and F.M. Blyth, Are self-management strategies effective in chronic pain treatment? Pain Manag, 2015.
  23. Morris, S., S. McLaren, A.J. McLachlan, and M. Jenkins, Sense of belonging to specific communities and depressive symptoms among Australian gay men. J Homosex, 2015. 62(6): p. 804-20.
  24. Machado, G.C., C.G. Maher, P.H. Ferreira, M.B. Pinheiro, C.W. Lin, R.O. Day, A.J. McLachlan, and M.L. Ferreira, Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials. BMJ, 2015. 350: p. h1225.
  25. Mach, J., A. Huizer-Pajkos, S.J. Mitchell, C. McKenzie, L. Phillips, A. Kane, B. Jones, R. de Cabo, V. Cogger, D.G. Le Couteur, and S.N. Hilmer, The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundam Clin Pharmacol, 2015.
  26. Mach, J., A. Huizer-Pajkos, A. Kane, B. Jones, C. McKenzie, S.J. Mitchell, R. de Cabo, V.C. Cogger, D.G. Le Couteur, and S.N. Hilmer, The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Exp Gerontol, 2015. 67: p. 54-61.
  27. Lowres, N., I. Krass, L. Neubeck, J. Redfern, A.J. McLachlan, A.A. Bennett, and S.B. Freedman, Atrial fibrillation screening in pharmacies using an iPhone ECG: a qualitative review of implementation. Int J Clin Pharm, 2015. 37(6): p. 1111-20.
  28. Liang, X., J.E. Grice, Y. Zhu, D. Liu, W.Y. Sanchez, Z. Li, D.H. Crawford, D.G. Le Couteur, V.C. Cogger, X. Liu, Z.P. Xu, and M.S. Roberts, Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small, 2015. 11(14): p. 1711-20.
  29. Lee, L., M. Heffernan, G. McDonnell, S.D. Short, and V. Naganathan, A system dynamics modelling approach to studying the increasing prevalence of people with intellectual developmental disorders in New South Wales. Aust Health Rev, 2015.
  30. Lee, J.W., Y. Kim, V. Perera, A.J. McLachlan, and K.S. Bae, Prediction of plasma caffeine concentrations in young adolescents following ingestion of caffeinated energy drinks: a Monte Carlo simulation. Eur J Pediatr, 2015. 174(12): p. 1671-8.
  31. Le Couteur, D.G., S.S. Tay, S. Solon-Biet, P. Bertolino, A.C. McMahon, V.C. Cogger, F. Colakoglu, A. Warren, A.J. Holmes, N. Pichaud, M. Horan, C. Correa, R.G. Melvin, N. Turner, J.W. Ballard, K. Ruohonen, D. Raubenheimer, and S.J. Simpson, The Influence of Macronutrients on Splanchnic and Hepatic Lymphocytes in Aging Mice. J Gerontol A Biol Sci Med Sci, 2015. 70(12): p. 1499-507.
  32. Le Couteur, D.G., S. Solon-Biet, V.C. Cogger, S.J. Mitchell, A. Senior, R. de Cabo, D. Raubenheimer, and S.J. Simpson, The impact of low-protein high-carbohydrate diets on aging and lifespan. Cell Mol Life Sci, 2015.
  33. Korprasertthaworn, P., T.M. Polasek, M.J. Sorich, A.J. McLachlan, J.O. Miners, G.T. Tucker, and A. Rowland, In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism. Drug Metab Dispos, 2015. 43(11): p. 1806-14.
  34. Huizer-Pajkos, A., A.E. Kane, S.E. Howlett, J. Mach, S.J. Mitchell, R. de Cabo, D.G. Le Couteur, and S.N. Hilmer, Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. J Gerontol A Biol Sci Med Sci, 2015.
  35. Hsu, B., R.G. Cumming, L.M. Waite, F.M. Blyth, V. Naganathan, D.G. Le Couteur, M.J. Seibel, and D.J. Handelsman, Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. J Clin Endocrinol Metab, 2015. 100(6): p. 2223-30.
  36. Hsu, B., R.G. Cumming, M.J. Seibel, V. Naganathan, F.M. Blyth, K. Bleicher, A. Dave, D.G. Le Couteur, L.M. Waite, and D.J. Handelsman, Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project. J Bone Miner Res, 2015. 30(9): p. 1701-8.
  37. Hsu, B., R.G. Cumming, F.M. Blyth, V. Naganathan, D.G. Le Couteur, M.J. Seibel, L.M. Waite, and D.J. Handelsman, The longitudinal relationship of sexual function and androgen status in older men: the Concord Health and Ageing in Men Project. J Clin Endocrinol Metab, 2015. 100(4): p. 1350-8.
  38. Hoy, D.G., E. Smith, M. Cross, L. Sanchez-Riera, F.M. Blyth, R. Buchbinder, A.D. Woolf, T. Driscoll, P. Brooks, and L.M. March, Reflecting on the global burden of musculoskeletal conditions: lessons learnt from the global burden of disease 2010 study and the next steps forward. Ann Rheum Dis, 2015. 74(1): p. 4-7.
  39. Ho, S.S., A.J. McLachlan, T.F. Chen, D.E. Hibbs, and R.A. Fois, Relationships Between Pharmacovigilance, Molecular, Structural, and Pathway Data: Revealing Mechanisms for Immune-Mediated Drug-Induced Liver Injury. CPT Pharmacometrics Syst Pharmacol, 2015. 4(7): p. 426-41.
  40. Hirani, V., V. Naganathan, F. Blyth, D.G. Le Couteur, P. Kelly, D.J. Handelsman, L.M. Waite, and R.G. Cumming, Cross-Sectional and Longitudinal Associations Between Anemia and Frailty in Older Australian Men: The Concord Health and Aging in Men Project. J Am Med Dir Assoc, 2015. 16(7): p. 614-20.
  41. Hirani, V., R.G. Cumming, F. Blyth, V. Naganathan, D.G. Le Couteur, L.M. Waite, D.J. Handelsman, and M.J. Seibel, Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: the Concord Health and Ageing in Men Project. Age (Dordr), 2015. 37(1): p. 9749.
  42. Hirani, V., F.M. Blyth, V. Naganathan, R.G. Cumming, D.G. Le Couteur, D.J. Handelsman, L.M. Waite, and M.J. Seibel, Active vitamin D (1,25 dihydroxyvitamin D) is associated with chronic pain in older Australian men: the Concord Health and Ageing in Men Project. J Gerontol A Biol Sci Med Sci, 2015. 70(3): p. 387-95.
  43. Hirani, V., F. Blyth, V. Naganathan, D.G. Le Couteur, M.J. Seibel, L.M. Waite, D.J. Handelsman, and R.G. Cumming, Sarcopenia Is Associated With Incident Disability, Institutionalization, and Mortality in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. J Am Med Dir Assoc, 2015. 16(7): p. 607-13.
  44. Held, F.P., F. Blyth, D. Gnjidic, V. Hirani, V. Naganathan, L.M. Waite, M.J. Seibel, J. Rollo, D.J. Handelsman, R.G. Cumming, and D.G. Le Couteur, Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project. J Gerontol A Biol Sci Med Sci, 2015.
  45. He, S.Z., et al., A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia. Leuk Lymphoma, 2015. 56(5): p. 1406-15.
  46. Gopinath, B., J. Jagnoor, M. Nicholas, F. Blyth, I.A. Harris, P. Casey, and I.D. Cameron, Presence and predictors of persistent pain among persons who sustained an injury in a road traffic crash. Eur J Pain, 2015. 19(8): p. 1111-8.
  47. Gopinath, B., J. Jagnoor, I.A. Harris, M. Nicholas, C.G. Maher, P. Casey, F. Blyth, D. Sindhusake, and I.D. Cameron, Comparison of health outcomes between hospitalised and non-hospitalised persons with minor injuries sustained in a road traffic crash in Australia: a prospective cohort study. BMJ Open, 2015. 5(9): p. e009303.
  48. Gopinath, B., J. Jagnoor, I.A. Harris, M. Nicholas, P. Casey, F. Blyth, C.G. Maher, and I.D. Cameron, Prognostic indicators of social outcomes in persons who sustained an injury in a road traffic crash. Injury, 2015. 46(5): p. 909-17.
  49. Gopinath, B., I.A. Harris, M. Nicholas, P. Casey, F. Blyth, C.G. Maher, and I.D. Cameron, A comparison of health outcomes in older versus younger adults following a road traffic crash injury: a cohort study. PLoS One, 2015. 10(4): p. e0122732.
  50. Gnjidic, D., S.A. Pearson, S.N. Hilmer, J. Basilakis, A.L. Schaffer, F.M. Blyth, E. Banks, and I. High Risk Prescribing, Manual versus automated coding of free-text self-reported medication data in the 45 and Up Study: a validation study. Public Health Res Pract, 2015. 25(2): p. e2521518.
  51. Gnjidic, D., V. Naganathan, S.B. Freedman, C.E. Beer, A.J. McLachlan, G.A. Figtree, and S.N. Hilmer, Statin Therapy and Cognition in Older People: What is the Evidence? Curr Clin Pharmacol, 2015. 10(3): p. 185-93.
  52. Gnjidic, D., A. Bennett, D.G. Le Couteur, F.M. Blyth, R.G. Cumming, L. Waite, D. Handelsman, V. Naganathan, S. Matthews, and S.N. Hilmer, Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. Int J Cardiol, 2015. 192: p. 49-55.
  53. Gibney, J., C. Wright, A. Sharma, and V. Naganathan, Nurses' knowledge, attitudes, and current practice of daily oral hygiene care to patients on acute aged care wards in two Australian hospitals. Spec Care Dentist, 2015. 35(6): p. 285-93.
  54. Falster, M.O., L.R. Jorm, K.A. Douglas, F.M. Blyth, R.F. Elliott, and A.H. Leyland, Sociodemographic and health characteristics, rather than primary care supply, are major drivers of geographic variation in preventable hospitalizations in Australia. Med Care, 2015. 53(5): p. 436-45.
  55. de Luca, K., L. Parkinson, H. Pollard, J. Byles, and F. Blyth, How is the experience of pain measured in older, community-dwelling people with osteoarthritis? A systematic review of the literature. Rheumatol Int, 2015. 35(9): p. 1461-72.
  56. DALYs, G.B.D., et al., Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet, 2015. 386(10009): p. 2145-91.
  57. Collaborators, G.B.D.R.F., et al., Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 2015. 386(10010): p. 2287-323.
  58. Cogger, V.C., J.N. O'Reilly, A. Warren, and D.G. Le Couteur, A standardized method for the analysis of liver sinusoidal endothelial cells and their fenestrations by scanning electron microscopy. J Vis Exp, 2015(98): p. e52698.
  59. Chan, J.G., A.S. Tyne, A. Pang, A.J. McLachlan, V. Perera, J.C. Chan, W.J. Britton, H.K. Chan, C.C. Duke, P.M. Young, and D. Traini, Murine pharmacokinetics of rifapentine delivered as an inhalable dry powder. Int J Antimicrob Agents, 2015. 45(3): p. 319-23.
  60. Blyth, F.M., D.A. Van Der Windt, and P.R. Croft, Chronic Disabling Pain: A Significant Public Health Problem. Am J Prev Med, 2015. 49(1): p. 98-101.
  61. Aitken, S.J., V. Naganathan, and F.M. Blyth, Aortic aneurysm trials in octogenarians: Are we really measuring the outcomes that matter? Vascular, 2015.
  62. Abdel Shaheed, C., C.G. Maher, K.A. Williams, and A.J. McLachlan, Pharmacists' views on implementing a disease state management program for low back pain. Aust J Prim Health, 2015.
  63. Abdel Shaheed, C., C.G. Maher, W. Mak, K.A. Williams, and A.J. McLachlan, The effects of educational interventions on pharmacists' knowledge, attitudes and beliefs towards low back pain. Int J Clin Pharm, 2015. 37(4): p. 616-25.
  64. Abdel Shaheed, C., C.G. Maher, W. Mak, K.A. Williams, and A.J. McLachlan, Knowledge and satisfaction of pharmacists attending an educational workshop on evidence-based management of low back pain. Aust J Prim Health, 2015. 21(2): p. 126-31.
  65. Wright, Clive (2015). Guest Editorial. Oral health care and older people. Australian and New Zealand Journal of Dental and Oral Health Therapists. April 2015.

Book Chapters:
  1. de Cabo R, Le Couteur DG. Chapter 94e. The Biology of Aging. In: Harrisons Principles of Internal Medicine (19th Ed) Editors: Kasper D, Fauci A, Hauser S, Longo D, Hauser S, Jameson JL, Loscalzo J. McGraw Hill Education, Columbus pp94e1-94e7, 2015 [ISBN 978-0071802154].
  2. Le Couteur DG, McLachlan AJ, Hilmer SN. Chapter 24. Principles of medication management. In: Oxford Textbook of Geriatric Medicine Editor: Martin F (in press) 2016. Oxford University Press, Oxford.

Presentations:

National and International:

Professor David Le Couteur

  1. 2015 ANZSGM (South Australia) 'Polypharmacy and deprescribing' 'Prescribing in the elderly'
  2. 2015 ANZSGM (NSW) FOAP Leura 'Polypharmacy and deprescribing'
  3. 2015 ASCEPT Hobart, Rand Medal Award 'Greenfields of geriatric pharmacology'

Associate Professor Victoria Cogger

  1. 2015 CERA Seminar 'Age-related hepatic insulin resistance: time to throw old ideas out the window?'
  2. 2015 Charles Perkins Biology Domain Series 'The liver microcirculation and age-related insulin resistance'

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE Total $$ Years
NHMRC Project #1024450 Banks, Le Couteur, Pearson, McLachlan, Viney, Hilmer, Gnjidic, Blyth, Joshy High risk prescribing in older Australians  $   577,181 2012-2016
NHMRC CRE #1060407 McLachlan, Pearson, Banks, Preen, Le Couteur et al Medicines and Ageing  $2,446,505 2014-2018
NHMRC Project #1066172 Turner, Sinclair, Le Couteur NAD+ and SIRT2 regulation of mitotic lifespan, senescence and healthy ageing  $   595,220 2014-2017
NHMRC Project Grant Cumming, Wright, Hirani, Naganathan, Blyth & Harford Study of the relationship of oral health & oral health utilization to general health  $   473,258 2014-2015
ARC Discovery DP160101119 Simpson, James, Raubenheimer, Conigrave, Le Couteur Regulation of protein appetite  $   379,000 2016-2018
NHMRC Project #1101913 Simpson, Le Couteur, James, Cogger Molecular mechanisms linking nutrition and age-related health  $    376,012 2016-2018
NHMRC Project Grant APP1042073 Chun-Wei, Lin, Maher, McLachlan, Latimer, Koes, Hancock, Harris PRECISE: pregabalin in addition to usual care for sciatica  $    618,589 2013-2015
NHMRC Project Grant APP1042073 Beer, Potter, Hilmer, Naganathan, McLachlan A randomised controlled trial of deprescribing to optimise medical therapy for frail older people: the Opti-Med study  $ 1,444,995 2013-2015
NHMRC Project Grant APP1082480 Chung-Wei, Lin, Maher, McLachlan, Latimer, Laurent Billot, Koes  The first placebo-controlled trial of opioid analgesics for acute spinal pain  $    996,237 2015-2017
NHMRC Partnership Project APP1094708 Day, Zwar, Reath, Westbrook, Lau, Baysari, Laba, McLachlan, Runciman Patient-centred eHealth approach to improving outcomes for gout sufferers  $    660,656 2015-2020
NHMRC Project Grant App 1065649 Cumming, Wright, Hirani, Naganathan, Blyth, Harford Study of the relationship of oral health and oral health service utilisation to the general health of older Australian men  $    459,723 2014-2016

Contact details for department

Head of Department: Professor David Le Couteur

Department/Unit: Centre for Education and Research on Ageing (CERA)
Address:
Concord Hospital
Hospital Road
Concord NSW 2139
Telephone: (02) 9767 7212
Facsimile: (02) 9767 5419
Web: aaainstitute.com.au
Email: david.lecouteur@sydney.edu.au