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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Drug Health Services

Our Research

Research within Drug Health Services adopts a multi-disciplinary approach and encompasses a broad range of disciplines including clinical toxicology, addiction medicine, public health, epidemiology, hepatology, mental health and indigenous health. There are direct links to the University of Sydney (USYD) including the School of Pharmacology and long standing affiliations with AW Morrow Gastroenterology and Liver Centre (AWM) and the Centenary Institute of Cancer Medicine and Cell Biology (CI). There are multiple collaborations with the National Drug and Alcohol Research Centre (NDARC) at the University of NSW.

Addiction Medicine provides a multidisciplinary approach to address problems of Alcohol, tobacco and illicit substance use and related harms. The DHS team has conducted a number of randomized controlled trials to test new treatments for alcohol and related disorders. Clinical service evaluations have been undertaken of both internal components of the clinical drug health service of SLHD and external agencies.

Public Health research in addiction medicine includes harms associated drug and alcohol use, such as blood-borne virus infection prevention and management, Needle and Syringe Programs, primary health care, a variety of treatment programs such as opioid substitution treatment, and specific women's and children's health and social issues.

Indigenous Health research (led by Professor Kate Conigrave) is involved in innovative approaches to translate knowledge to action using local Aboriginal language and concepts for health promotion efforts and to address substance use and related issues in remote communities. A key feature of this work is partnering with local Aboriginal communities, so the research conducted is initiated and led by the local communities involved. In urban NSW, our approach to mobilise communities around alcohol is the first of its kind, and the resources developed from this project have since been adopted for use by the NT Government and the Aboriginal Drug and Alcohol Network (ADAN) in NSW.

Biomedical and Genetic research in liver disease, particularly related to alcohol, is an important area of research at DHS. Our clinical and basic research in liver disease aims to understand the mechanisms of how alcohol injures the liver and identify potential markers as therapeutic and/or diagnostic agents. The team is currently investigating the mechanisms of action of novel molecules and pathways in the development of liver fibrosis and cirrhosis in animal and cell culture models of alcohol. An international GenomALC Consortium has been established for the genetic study along with the development of the largest clinically well characterised databank and biobank on drinkers worldwide.

Clinical Research in Alcohol Treatment and associated mental health is a major area of interest with ongoing randomised control trials, including comorbid substance abuse and suicide risk. The team (led by Prof Paul Haber) is leading world first research into alcohol dependence, alcohol liver disease and their associated psychological comorbidities under the NHMRC Centre of Research Excellence in Mental Health and Substance Use. Clinical toxicology's scope includes acute and chronic medicine and chemical poisoning, serious adverse prescribed and non-prescribed drug reactions and toxicology that create a substantial source of morbidity and mortality across the world. The team (led by Professor Andrew Dawson) has established the largest prospective cohort of acute poisoning in the world, oversees The Australian National Poisons Registry and developed treatment guidelines resulting in policy and regulatory changes.

Translational Research: The Research Unit continuously trains and teaches medical and science graduates (Honours, Masters, MPhil and PhD) and Indigenous Health (GradDip). The Research Unit at DHS is engaged in the placement of overseas trainees/students, teaching/training of GPs and Aboriginal drug and alcohol workers and other clinicians across Australia and has developed Masters Clinical Toxicology distance learning course and Opensource curriculum.

Opportunities exist to undertake post graduate studies in the above areas, from a basic science, clinical or public health perspective.

Key Achievements

  • Largest Clinical Trial - Baclofen Detail: Completed the largest trial of baclofen for the treatment of alcohol dependence in the world (last 10 patients recruited in 2016).
  • Completed the first neuroimaging a study of baclofen in alcohol patients in the world (last 10 patients recruited in 2016).
  • Completed the first pharmacokinetic and cue-reactivity study of baclofen in alcohol patients with liver disease versus non liver disease.
  • Awarded NHMRC project grant in 2015 to undertake a trial of topiramate for alcohol dependence using a personalised medicine approach.
  • Completion of IVAHC (Impact of Vertically Acquired Hepatitis C) Pilot cohort study.
  • Media Coverage:
    • Channel 7 News 23 July 2015 'New research suggests a genetic link in alcoholic liver disease.'
    • The Daily Telegraph 22 July 2015 'A high fat diet increases chances of alcoholic liver disease.'
    • Channel 10 News 12 November 2015 'The silent epidemic of liver disease - one of our biggest health burdens.'
    • 'Benzo-opioid combo concern', Medical Observer, 23 June 2015.
    • Arsenic contamination of rice cakes', ABC Canberra 666, 9 October 2015.

Awards/Medals

  • Award name: Team Excellence award and a $500 cheque. Details: For leading the Gender Equity Program as Chair at the Centenary Institute. Outstanding team performance.
  • Award name: Honoured as outstanding woman for her leadership and contribution to her research field. Details: Selected as one of three outstanding women for their leadership and contribution to their respective research field by Prof Belinda Hutchinson (Chancellor, University of Sydney) at the Centenary Institute's AGM.
  • Award name: Appointed as Peer Advisory Committee member for Franklin Women. Details: Franklin Women (https://franklinwomen.com.au/) is Australia's only community for women working in health and medical research related careers, providing unique opportunities for personal and professional development. FW Peer Advisory committee has many functions, such as organising events and reviewing travel scholarships for early/mid-career women in medical research.
  • 2015 Sri Lanka Association of Clinical Pharmacology and Therapeutics Inauguration Chief Guest Finding Pharmacologists.
  • 2016 FACMT: Fellow of American College of Medical Toxicology.

Research Staff

  • Professor Paul Haber, Clinical Director
  • Professor Andrew Dawson, Senior Staff Specialist
  • Professor Nicholas Buckley, Clinical Academic
  • Associate Professor Andrew Baillie, Honorary Clinical Psychologist
  • Dr Bethany White, Postdoctoral Research Associate
  • A/Professor Carolyn Day, Drug and Alcohol Coordinator, Sydney Medical School
  • Dr Cathy Heyes, Clinician
  • A/Prof Darren Roberts, Staff Specialist
  • A/Prof Devanshi Seth, Principal Scientist
  • Ms Jessica Hyman, Research Assistant
  • Ms Khairunnessa Rahman, Research Assistant
  • Professor Katherine Conigrave, Senior Staff Specialist
  • Dr Kirsten Morley, Senior Research Fellow
  • Dr Kylie Lee, Lecturer
  • Dr Richard Hallinan, Staff Specialist
  • Dr Sharon Reid, Career Medical Officer
  • Mr Warren Lodge, PhD Student
  • Dr Kenneth Curry, Senior Staff Specialist
  • Ms Ann White, Clinical Nurse Consultant
  • Dr Bridin Murnion, Senior Staff Specialist
  • Dr Jonathan Brett, Staff Specialist

Higher Degree Students:

PhD:

  • Mr Bishan Rajapakse
  • Mr Fahim Mohammed
  • Ms Angela Chiew
  • Ms Melissa Pearson 
  • Mr Tim Pianta
  • Ms Bianca Blanch
  • Mr Kevin Liou
  • Ms Andrea Schaffer
  • Dr Jonathon Brett
  • Thilini Wijerathne
  • Mr Colin Page
  • Vindya Pathirana
  • Mr Ben Daniels
  • Lakmini DeSilva
  • Janaka Pushpakumara
  • Maryssa Portelli
  • Ms Kerryn Butler
  • Ms Basma Al Ansari
  • Ms Sandi Mitchell
  • Dr Sharon Reid


Publications and Presentations

Publication Details:
  1. Lee KSK, Sukavatvibul K & Conigrave KM (2015). Cannabis use and violence in three remote Aboriginal Australian communities: Analysis of clinic presentations. Transcultural Psychiatry, 52, 827-39.
  2. Lee KSK, Harrison M, Miller W & Conigrave KM Opportunities for integrated learning in a drug and alcohol university degree for Aboriginal and Torres Strait Islander adults: a case study. Aboriginal and Islander Health Worker Journal. (in press accepted 2014).
  3. Morley, K. C., Logge, W., Pearson, S., Baillie, A, Haber, P. National trends in alcohol treatment: Findings from an Australian claims database. Drug and Alcohol Dependence (accepted with revisions ).
  4. Morley, K.C., Baillie, A., Leung, S., Teesson, M., Sannibale, C. Haber. P.S (2015). Is specialised integrated treatment for comorbid anxiety depression and alcohol use disorder better than treatment as usual in a public hospital setting? Alcohol and Alcoholism, epub pii: agv131.
  5. Buckley NA, Dawson AH, Whyte IM, Isbister GK. A prospective cohort study of trends in self-poisoning, Newcastle, Australia, 1987-2012: plus ça change, plus c'est la même chose. Medical Journal of Australia 2015; 202(8):438-443.
  6. Schaffer A, Buckley NA, Dobbins T, Banks E, Pearson SA. The crux of the matter: Did the ABC's Catalyst program change statin use in Australia? Medical Journal of Australia 2015;202(11):591-595. IF:2.853 Winner of the MJA / MDA National Research Award for the best research article published in the MJA in 2015
  7. Isbister GK, Maduwage K, Saiao A, Buckley NA, Jayamanne SF, Seyed S, Mohamed F, Mendes A, Abeysinghe C, Karunathilake H, Gawarammana I, Lalloo DG, de Silva HJ. Population pharmacokinetics of an Indian F(ab')2 snake antivenom in patients with Russell's viper (Daboia russelii) bites. PloS Neglected Tropical Diseases 2015 Jul 2;9(7):e0003873.
  8. Pianta TJ, Peake PW, Pickering JW, Kelleher M, Buckley NA, Endre ZH. Evaluation of Biomarkers of Cell Cycle Arrest and Inflammation in Prediction of Dialysis or Recovery after Kidney Transplantation. Transplantation International 2015 28(12):1392-404.
  9. Maduwage K, Buckley NA, de Silva HJ, Lalloo DG, Isbister GK. Snake antivenom for snake venom induced consumption coagulopathy. Cochrane Database of Systematic Reviews 2015, Issue 6. Art. No.: CD011428. DOI: 10.1002/14651858.CD011428.pub2.
  10. Mohammed F, Buckley NA, Jayamanne FS, Pickering J, Peake P, Pallangasinghe C, Wijerathna T, Ratnayake I, Shihana F, Endre ZH. Kidney damage biomarkers detect acute kidney injury but only functional markers predict mortality after paraquat ingestion. Toxicology Letters 2015; 237(2):140-50.
  11. Blanch B, Buckley NA, Mellish L, Dawson A, Haber PS, Pearson SA. Harmonizing post-market surveillance of prescription drug misuse: A systematic review of observational studies using routinely collected data (2000-2013). Drug Safety 2015; 38(6):553-64
  12. Pianta TJ, Endre ZH, Pickering JW, Buckley NA, Peake PW. Kinetic Estimation of GFR Improves Prediction of Dialysis and Recovery After Kidney Transplantation. PLoS One 2015; 10(5):e0125669.
  13. Owens K, Medlicott N, Zacharias M, Whyte I, Buckley NA, Reith D. Population pharmacokinetic-pharmacodynamic (PKPD) modelling to describe the effects of paracetamol and N-acetylcysteine on the International Normalised Ratio (INR). Clinical and Experimental Pharmacology and Physiology 2015;42(1):102-8.
  14. The End-of-Life in Cancer Care (EoL-CC) Investigators: Langton JM, Srasuebkul P, Reeve R, Parkinson B, Gu Y, Buckley NA, Haas M, Viney R, Pearson SA. Resource use, costs and quality of end of life care: Observations in a cohort of elderly Australian cancer decedents. Implementation Science 2015;10(1):25.
  15. Mohammed F, Endre ZH, Jayamanne FS, Pianta T, Peake P, Pallangasinghe C, Chathuranga U, Jayasekera KB, Wunnapuk K, Shihana F, Shahmy S, Buckley NA. Mechanisms underlying early rapid increases in creatinine in paraquat poisoning. PLoS One 2015; 10(3):e0122357
  16. Peake P, Pianta TJ, Succar L, Fernando M, Buckley NA, Endre Z. Fab fragments of ovine antibody to colchicine enhance its clearance in the rat. Clinical Toxicology 2015;53:427-432.
  17. Pianta TJ, Peake PW, Pickering JW, Kelleher M, Buckley NA, Endre ZH. Clusterin in Kidney Transplantation: Novel Biomarkers Versus Serum Creatinine for Early Prediction of Delayed Graft Function. Transplantation 2015;99(1):171-9.
  18. Pearson SA, Abrahamowicz M, Srasuebkul P, Buckley NA. Antidepressant therapy in cancer patients: incidence and factors associated with initiation. Pharmacoepidemiology and Drug Safety 2015; 24(6):600-9.
  19. Pearson M, Zwi AB, Buckley NA, Manuweera G, Fernando R, Dawson AH, McDuie-Ra D. Policymaking 'under the radar': a case study of pesticide regulation to prevent intentional poisoning in Sri Lanka. Health Policy and Planning 2015; 30:56-673
  20. Roberts DM, Liu X, Roberts JA, Nair P, Cole L, Roberts MS, Lipman J, Bellomo R. A multicentre study on the effect continuous hemodiafiltration intensity on antibiotic pharmacokinetics. Critical Care 2015; 19(1): 84.
  21. Juurlink DN, Gosselin S, Kielstein JT, Ghannoum M, Lavergne V, Nolin TD, Hoffman RS; EXTRIP Workgroup. Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup. Ann Emerg Med. 2015 Aug;66(2):165-81.
  22. Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, Ghannoum M; EXTRIP workgroup. Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Critical Care Medicine 2015; 43(8): 1716-30.
  23. Jamal JA, Roberts DM, Udy AA, Mat-Nor MB, Mohamad-Nor FS, Wallis SC, Lipman J, Roberts JA. Pharmacokinetics of piperacillin in critically ill patients receiving continuous venovenous haemofiltration: A randomized controlled trial of continuous infusion versus intermittent bolus administration. International Journal of Antimicrobial Agents 2015; 46(1): 39-44.
  24. Ghannoum M, Wiegand TJ, Liu KD, Calello DP, Godin M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS; EXTRIP workgroup. Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015; 53(4): 215-29.
  25. Bouchard J, Ghannoum M, Bernier-Jean A, Williamson D, Kershaw G, Weatherburn C, Eris JM, Tran H, Patel JP, Roberts DM. Comparison of intermittent and continuous extracorporeal treatments for the enhanced elimination of dabigatran. Clin Toxicol (Phila) 2015;53(3): 156-63.
  26. Roberts DM, Jones RB, Smith RM, Alberici F, Kumaratne DS, Burns S, Jayne DRW. Rituximab-associated hypogammaglobulinemia: Incidence, predictors and outcomes in patients with multi-system autoimmune disease. Journal of Autoimmunity 2015; 57: 60-5.
  27. Roberts DM, Jones RB, Smith RM, Alberici F, Kumaratne DS, Burns S, Jayne DRW. Immunoglobulin G replacement for the treatment of infective complications of rituximab-associated hypogammaglobulinaemia in autoimmune disease: a case series. Journal of Autoimmunity 2015;57:24-9.
  28. Roberts DM, Yates C, Megarbane B, Winchester JF, Maclaren R, Gosselin S, Nolin TD, Lavergne V, Hoffman RS, Ghannoum M, EXTRIP work group. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning. A systematic review and consensus statement. Critical Care Medicine 2015; 43(2): 461-72
  29. Alberici F, Smith RM, Jones RB, Roberts DM, Willcocks LC, Chaudhry A, Smith KGC, Jayne DRW. Long term follow-up of patients who received repeat dose Rituximab as maintenance therapy for ANCA associated vasculitis. Rheumatology 2015; 54(7):1153-60.
  30. Ghannoum M, Calello DP, Lavergne V, Gosselin S, Liu, KD, Roberts DM. Metformin poisoning: A debate on recommendations for extracorporeal treatment; In reply. Critical Care Medicine 2015 43(11): e534-e535.
  31. Roberts DM, Hoffman RS, Gosselin S, Megarbane B, Yates C, Ghannoum M. Treatment decisions in epidemics of methanol poisoning. Critical Care Medicine 2015; 43(6): e211-2.
  32. PJ Meikle, PA Mundra, G Wong, K Rahman, K Huynh, CK. Barlow, AMP Duly, PS Haber, JB Whitfield, D Seth. Circulating Lipids are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment. PLoS One 2015, 10 (6): e0130346.
  33. Habeeb Salameh, Evan Raff, Angelika Erwin, Devanshi Seth, Hans D Nischalke, Edmondo Falleti, Maria A Burza, Julian Leathert, Stefano Romeo, Antonio Molinaro, Stefano G Corradini, Pierluigi Toniutto, Spengler Ulrich, Ann Daly, Christopher P Day, Ashwani K. Singal. PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease. Am J Gastroenterol 2015, 110:846-856.
  34. AMP Duly, B Alani, EY-W Huang, C Yee, PS Haber, SV McLennan, D Seth. Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. Nutrition & Diabetes 2015, 5:e154-e162.
  35. Whitfield J, Rahman K, Haber P, Day C, Masson S, Daly A, Cordell H, Mueller S, Seitz H, Liangpunsakul S, Westerhold C, Liang T, Lumeng L, Foroud T, Nalpas B, Mathurin P, Stickel F, Soyka M, Botwin G, Morgan T, Seth, D and the GenomALC Consortium. Brief Report: Genetics of Alcoholic Cirrhosis: GenomALC Multinational Study. Alcoholism: Clin Exp Res 2015, 39 (5):836-842.
  36. Blanch B, Buckley NA, Mellish L, Dawson AH, Haber PS, Sallie-Anne Pearson SA. Harmonizing post-market surveillance of prescription drug misuse: A systematic review of observational studies using routinely collected data (2000-2013). Drug Saf. 2015 Jun;38(6):553-64
  37. Dharmaratne S, Husna R, Ponnamperuma G, Marambe K, Dawson A, Balasooriya C. Vignette-based decision point analysis (VDPA): a novel method of exploring person-centered contextual influences on clinical decision-making. European Journal for Person Centered Healthcare 3, No. 2 (2015): 151-157
  38. Buckley NA, Whyte IM, Dawson AH, Isbister GK. A prospective cohort study of trends in self-poisoning, Newcastle, Australia, 1987-2012: Plus ça change, plus c'est la même chose. Med J Aust 2015, May 4;202(8):438-42.
  39. Wijesinghe CA, Williams SS, Kasturiratne A, Dolawaththa N, Wimalaratne P, Wijewickrema B, et al. A randomized controlled trial of a brief intervention for delayed psychological effects in snakebite victims. PLoS Negl Trop Dis 2015, Aug;9(8):e0003989.
  40. Coombes I, CoombesJ , Dawson AH. Clinical pharmacy in Sri Lanka: translating training into practice Journal of Pharmacy Practice and Research (2015) 45, 1-2
  41. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium - theory, evidence and practice. Br J Clin Pharmacol 2015, Nov 21.
  42. Galappatthy P, Dawson AH. Paracetamol overdose: Relevance of recent evidence for managing patients in Sri Lanka. Ceylon Medical Journal 2015;60(3).
  43. Hermens DF, Chitty KM, Lee RS, Tickell A, Haber PS, Naismith SL, Hickie IB, Lagopoulos J.Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression.J Affect Disord. 2015 Nov 1;186:95-8
  44. Fortier E, Alavi M, Micallef M, Dunlop AJ, Balcomb AC, Day CA, Treloar C, Bath N, Haber PS, Dore GJ, Bruneau J, Grebely J; ETHOS Study Group. The effect of social functioning and living arrangement on treatment intent, specialist assessment and treatment uptake for hepatitis C virus infection among people with a history of injecting drug use: The ETHOS study. Int J Drug Policy. 2015 Nov;26(11):1094-102.
  45. Alavi M, Spelman T, Matthews GV, Haber PS, Day C, van Beek I, Walsh N, Yeung B, Bruneau J, Petoumenos K, Dolan K, Kaldor JM, Dore GJ, Hellard M, Grebely J; ATAHC Study Group. Injecting risk behaviours following treatment for hepatitis C virus infection among people who inject drugs: The Australian Trial in Acute Hepatitis C.Int J Drug Policy. 2015 Oct;26(10):976-83.
  46. Wang D, Lintzeris N, Leung S, Haber PS, Yee BJ, Grunstein RR. Reversal of central sleep apnoea with change from methadone to buprenorphine-naloxone: a case report. Eur Respir J. 2015 Oct;46(4):1202-5.
  47. Alavi M, Micallef M, Fortier E, Dunlop AJ, Balcomb AC, Day CA, Treloar C, Bath N, Haber PS, Dore GJ, Grebely J; ETHOS Study Group. Effect of treatment willingness on specialist assessment and treatment uptake for hepatitis C virus infection among people who use drugs: the ETHOS study. J Viral Hepat. 2015 Nov;22(11):914-25.
  48. Blanch B, Buckley NA, Mellish L, Dawson AH, Haber PS, Pearson SA. Harmonizing post-market surveillance of prescription drug misuse: a systematic review of observational studies using routinely collected data (2000-2013). Drug Saf. 2015 Jun;38(6):553-64.
  49. Whitfield JB, Rahman K, Haber PS, Day CP, Masson S, Daly AK, Cordell HJ, Mueller S, Seitz HK, Liangpunsakul S, Westerhold C, Liang T, Lumeng L, Foroud T, Nalpas B, Mathurin P, Stickel F, Soyka M, Botwin GJ, Morgan TR, Seth D; GenomALC Consortium. Brief report: genetics of alcoholic cirrhosis-GenomALC multinational study. Alcohol Clin Exp Res. 2015 May;39(5):836-42.
  50. Haber PS, Day CA, Topp L, Shanahan M, Wand H, van Beek I, Maher L. Hepatitis B vaccination for people who inject drugs. Lancet. 2015 Jan 10;385(9963):115.
  51. Al-Ansari B. Thow A-M, Day C, Conigrave K. Overview of alcohol policies adopted by Muslim majority countries in the world: the impact of globalisation. Addiction (accepted 7 September 2015).
  52. Al-Ansari B, Day C, Thow A-M, Conigrave K. Civil alcohol policy in Muslim majority countries: need for global tools, expert support and local partnerships: Response to commentaries. Addiction.

Book Chapters:

Books:

  1. Saunders JB, Conigrave KM, Latt NC, Nutt DJ, Marshall J & Higuchi S (Eds) (in press, accepted March 12, 2015. Addiction Medicine. Oxford University Press.
  2. Haber P, Day C and Farrell M. (eds). Addiction Medicine: Principles and Practice. IP Communications, Melbourne, Australia 2015. ISBN 978-0-9925181-6-5
Book Chapters:
  1. Conigrave K, Lee K & Freeburn B (2015). Aboriginal and Torres Strait Islander Australians. In: P Haber, C Day & M Farrell, eds. Addiction medicine: principles and practice. Melbourne, Australia: IP Communications, 464.
  2. Roberts D, Buckley NA. Paraquat/Diquat poisoning in: In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA; September 2015.
  3. Buckley N. Organophosphorus poisoning. BMJ Knowledge/ePoCrates (commissioned monograph) 2015. https://online.epocrates.com/u/2911852/Organophosphate+poisoning/
  4. Buckley NA, Dawson AH, Whyte IM. Hypertox. Assessment and Treatment of Poisoning. A computerised educational text published in html and an essential text for Poisons Information Services in Australia. Also available on the Internet at "www.hypertox.com". Latest version Hypertox 2015.
  5. Reid S & Day C.Women and Drugs. In Haber P, Day C and Farrell M. (eds). Addiction Medicine: Principles and Practice. IP Communications, Melbourne.
  6. Roberts DM. 'Chapter 112. Herbicides'. In: Hoffman RS, Howland MA, Lewin NA, Nelson LS, Goldfrank LR (Eds). Goldfrank's Toxicologic Emergencies; 10th Edition, McGraw Hill, 2015.\
  7. Paull P, Haber PS, Seth D. Drug testing and biomarkers of alcohol consumption in Addiction medicine: principles and practice. Chapter 13:143-162. Editors: Haber P, Day C, Farrell M. Melbourne, Australia. IP Communications, 2015. ISBN 978-0-9925181-6-5 This is an invited review on biomarkers of alcohol consumption, as there are no effective biomarkers to date.
  8. Day C. (2015). Public health responses to drug and alcohol use. In Haber P, Day C and Farrell M. (eds). Addiction Medicine: Principles and Practice. IP Communications, Melbourne. Pp 36-47.

Presentations:

National or International:

  1. Plenary speaker; K. Conigrave and M. Doyle. 'What can nurses do to support Aboriginal and Torres Strait Islander Australians to address substance misuse?' Drug and Alcohol Nurses Association, Sydney, August 15, 2015
  2. Plenary speaker K Conigrave: 'Making alcohol and drug treatment more accessible to Indigenous communities'. Winter School, Brisbane, July 24, 2015
  3. Plenary speaker, Alcohol Tobacco and Other Drugs; Aboriginal Workers Forum, Adelaide Hills, SA 2015
  4. Plenary speaker, K Conigrave: Evaluation of ADAN. Annual Aboriginal Drug and Alcohol Network (ADAN) symposium, Coffs Harbour, 2015
  5. Symposium, Helping Aboriginal and Torres Strait Islander Australians with alcohol or drug problems. K Conigrave: Addiction Registrars November 2015, videolinked to other states including Tasmania
  6. Morley, K.C., Baillie, A., Leung, S., Teesson, M., Sannibale, C. Haber. P.S. Is specialised integrated treatment for comorbid anxiety depression and alcohol use disorder better than treatment as usual in a public hospital setting? Research Society on Alcoholism: Alcohol & Experimental Research: 39, Chicago, 2015.
  7. Morley, K. C., Haber, P., Sitharthan., G., Tucker., P., Sitharthan, R. Differentiating suicide attempters from suicide ideators in patients with comorbid substance use and suicide risk The NHMRC Centre of Research Excellence in Mental Health and Substance Use (CREMS) National Colloquium, Mental Health Services Conference, Canberra, August 25 2015.
  8. Morley, K.C., Baillie, A., Leung, S., Teesson, M., Sannibale, C. Haber. P.S. Is specialised integrated treatment for comorbid anxiety depression and alcohol use disorder better than treatment as usual in a public hospital setting? The NHMRC Centre of Research Excellence in Mental Health and Substance Use (CREMS) National Colloquium, Mental Health Services Conference, Canberra, August 25 2015.
  9. Ross, L., Morley, K. C., Haber, P. Exploring the feasibility and efficacy of a 'pop-up' tobacco cessation intervention (POP-NRT) for smokers with a history of homelessness The NHMRC Centre of Research Excellence in Mental Health and Substance Use (CREMS) National Colloquium, Mental Health Services Conference, Canberra, August 25 2015.
  10. Morley, K.C., Logge, W., Fraser, I. Baillie, A., Morris, R., Lagopolous, J., Haber, P. Exploring the neurobehavioural basis of baclofen, in the treatment of alcohol dependence The NHMRC Centre of Research Excellence in Mental Health and Substance Use (CREMS) National Colloquium,Mental Health Services Conference, Canberra, August 25 2015.
  11. Morley, K.C., Logge, W., Fraser, I. Baillie, A., Morris, R., Lagopolous, J., Haber, P. Exploring the neurobehavioural basis of baclofen in the treatment of alcohol dependence. The Inter-University Neuroscience & Mental Health Conference, UNSW, September 24-25 2015.
  12. Buckley NA. Pharmaceutical drug misuse - implications for post-market surveillance. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, December 2015.
  13. Buckley NA. Evidence in Clinical Toxicology - Pearls and Hidden Treasures. TAPNA meeting, Sydney May 2015.
  14. Schaffer A, Buckley NA, Dobbins T, Banks E, Pearson SA. The crux of the matter: Did the ABC's Catalyst program change statin use in Australia? International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE), Boston, August 2015. (Winner of the Stanley A. Edlavitch Award for the Best Student Abstract.)
  15. Albuquerque PLMM, Lopes IS, Veras MSB, Meneses GC, Silva JGB, Buckley N, Acute kidney injury caused by snakebites in patients admitted to a reference toxicological assistance center in northeast Brazil. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  16. Shihana F, Worek F, Shahmy S, Rathgamage S, Jeevan HK, Buckley NA. Evaluation of the 'CHE check mobile' accuracy in measurement of acetylcholinesterase and plasma cholinesterase in anticholinesterase poisoning. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  17. Ratnayake IU, Fahim M, Shihana F, Dissanayake DM, Buckley NA, Maduwage K, Chathuranga U, Aslam Z, Isbister GK. Urinary neutrophil gelatinase-associated lipocalin is an early biomarker of acute kidney injury following Russell's viper envenoming. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  18. Bracken LML, Buckley NA, Chan BSH, Chiew AL. Physiologically based pharmacokinetic modelling of digoxin for the treatment of digoxin toxicity. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  19. Mohamed F, Endre ZH, Pickering JW, Gawarammana I, Buckley NA. Mechanism-specific renal biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  20. Cairns R, Brown JA, Schaffer A, Pearson SA, Buckley NA. The impact of scheduling changes on alprazolam and codeine self-poisoning reported to the New South Wales Poisons Information Centre. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  21. Maduwage K, Buckley NA, de Silva HJ, Lalloo DG, Isbister GK. Snake antivenom for snake venom induced consumption coagulopathy - a Cochrane review. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  22. Albuquerque PLMM, Luna JRG, Alexandrino JEF, Freitas, MCTM, Silva JGB, Buckley N. Clinical and laboratory characteristics of patients intoxicated by cholinesterase inhibitors admitted to a reference toxicological assistance center in northeast Brazil. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  23. Shihana F, Buckley NA, Jayathilake RMC, Aslam MZ, Gawarammana IB, Mohamed F. Diagnostic profiles of novel urinary biomarkers in propanil-induced nephrotoxicity in limited resource hospital. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Perth, December 2015
  24. Silva A, Siribaddana S, Sedgwick EM, Maduwage K, Kuruppu S, Buckley NA, Hodgson W, Isbister GK. Neurotoxicity due to Sri Lankan Russell's viper envenomation is caused by a weak presynaptic neurotoxin. North American Congress of Clinical Toxicology, San Francisco 2015. Clinical Toxicology 2015;53(7):640 (Winner of the AACT Prize for the Outstanding Oral Presentation).
  25. Chan B, O'Leary M, Isbister G, Buckley NA. The Use of Digoxin-specific Antibodies in Chronic Digoxin Poisoning. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Malta May 2015. Clinical Toxicology 2015;53(4):241
  26. Berling I, Buckley NA, Isbister GK. The Antipsychotic Story... an epidemic of prescription and overdose. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Malta May 2015. Clinical Toxicology 2015;53(4):241
  27. Chiew AL, Isbister GK, Buckley NA. Massive Paracetamol Overdose. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Malta May 2015. Clinical Toxicology 2015;53(4):380.
  28. Isbister GK, Buckley NA, Page CB, Brown SGA. A multicentre cohort study of snake envenoming defines clinical syndromes and influences clinical practice. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Malta May 2015. Clinical Toxicology 2015;53(4):277-8.
  29. Silva A, Siribaddana S, Sedgwick EM, Maduwage K, Buckley NA, Isbister GK. Indian Krait (Bungarus caeruleus) envenoming: a clinical and neurophysiological investigation of neuromuscular dysfunction. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Malta May 2015. Clinical Toxicology 2015;53(4):352-3. (Winner of the EAPCCT young investigator award)
  30. Isbister GK, Maduwage K, Saiao A, Buckley NA, Jayamanne SF, Shahmy S, Mohamed F, Mendes A, Abeysinghe C, Karunathilake H, Gawarammana I, Lalloo DG, de Silva HJ. Population pharmacokinetics of an Indian F(ab')2 snake antivenom in patients with Russell's viper bite. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Malta May 2015. Clinical Toxicology 2015;53(4):240-1.
  31. Cairns R, Brown J, Robinson J, Lynch AM, Wylie C, Buckley NA. A decade of Australian methotrexate dosing errors: what more can be done? TAPNA meeting, Sydney May 2015
  32. Chan B, O'Leary M, Isbister G, Buckley NA. The Use of Digoxin-specific Antibodies in Acute Digoxin Poisoning. TAPNA meeting, Sydney May 2015.
  33. Mohamed F, Buckley NA, Peake P, Shihana F, Jayamanne S, Endre Z. Mechanism-specific biomarkers predict acute kidney injury (AKI) early following glyphosate surfactant herbicide (GPSH) poisoning. World Congress of Nephrology, Cape Town, March 2015 International: 'Elimination: renal clearance, enterohepatic circulation'. Annual Scientific Meeting of the European Association of Poison Control Centres and Clinical Toxicologists, Malta, 2015
  34. 'Update on Poisoning'. Annual Scientific Meeting of the Australia and New Zealand Society of Nephrology, Canberra, 2015 33. 'Journey from Diagnosis to Renal Replacement Therapy' and 'ICU case study'. SHPA conference, Canberra, May 2015
  35. 'Overview of changes in drug disposition with impaired kidney function'. Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart, December, 2015
  36. 'Vd in enhanced elimination'. Clinical weekend of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, May, 2015
  37. 'PKPD principles in clinical toxicology'. Clinical weekend of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, May, 2015
  38. 'Dosing of antibiotics in special populations'. Clinical weekend of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Sydney, May, 2015
  39. Seth D. Endothelial progenitor cell identification and liver regeneration (Invited presentation). Basic Research Workshop in Liver Diseases at the Asia Pacific Association for the Study of Liver (APASL) Single theme conference 2015: 'HCV Infection and Disease & Recent Advances in Liver Diseases', Institute of Liver and Biliary Sciences (ILBS), New Delhi, India.18-20 Dec 2015.
  40. Devanshi Seth, Emily Huang, Alastair Duly, Susan McLennan. Osteopontin plays a key role in alcohol and high fat diet induced liver injury. 50th International Liver Congress 2015 for the European Association for the Study of the Liver (EASL). 22-26 April, 2015, Vienna, Austria.
  41. Seth D, Huang E, McLennan S. A key role for osteopontin in alcohol and high fat diet induced liver injury. Hepatology and Gastrointestinal Research Workshop - Gastroenterological Society of Australia (GESA), 24-26 May 2015, Bowral, NSW, Australia.
  42. Seth D, Meikle P, Mundra P. Circulating lipids associated with alcoholic liver cirrhosis: potential biomarkers for risk assessment. Hepatology and Gastrointestinal Research Workshop - Gastroenterological Society of Australia (GESA), 24-26 May 2015, Bowral, NSW, Australia.
  43. Seth D and GenomALC Consortium. GenomALC Consortium study: genome-wide association in alcoholic liver cirrhosis. Hepatology and Gastrointestinal Research Workshop - Gastroenterological Society of Australia (GESA), 24-26 May 2015, Bowral, NSW, Australia.
  44. Dawson AH. Finding Pharmacologists. Guest of Honor. Inaugural meeting of the Sri Lanka Association of Clinical Pharmacology and Therapeutics October 3rd 2015 Colombo Sri Lanka
  45. Haber, Paul - Sydney Addiction Seminar - 'Alcohol - from the ED to the GP. What has changed?' - 14th October, 2015
  46. White B, Day CA, Black, K, Maher L. Pregnancy and Contraceptive Use among Young Women Who Inject Drugs in a Hepatitis C Virus Vaccine Preparedness Study. 4th International Symposium on Hepatitis Care in Substance Users, Sydney, Australia 7 - 9 October 2015.
  47. Bartlett S, Jacka B, Bull R, Luciani F, Matthews GV, Lamoury F, Hellard M, Teutsch S, White B, Maher L , Dore GJ, Lloyd A, Applegate T, Grebely J. High Connectivity is Associated with HIV Co-Infection in the Transmission Network of People with Recent Hepatitis C Virus Infection in Australia. 4th International Symposium on Hepatitis Care in Substance Users, Sydney, Australia 7 - 9 October 2015.
  48. Ezard N, Dolan K, Baldry E, Burns L, Hodge S, Cubitt T, Loesch B, Mackay T, Day CA. Feasibility of a Managed Alcohol Program for Sydney's Homeless. Presented at the Second National Complex Needs Conference, Canberra 17-18 November 2015.
  49. Day CA, White B, Reid S, Haber P, Black K. An integrated contraception clinic into a drug health service: a pilot study. Presented at the Second National Complex Needs Conference, Canberra 17-18 November 2015.
  50. Day CA, White B, Reid S, Haber P, Black K. Development of a contraception clinic in an Australian drug and alcohol treatment context: A pilot study. Invited presentation to International Women's Group Meeting, Phoenix Arizona, USA, 12 June 2015.
  51. Reid S et al Hepatitis C screening among infants born to hepatitis C positive women who inject drugs. 'Late Breaking' abstract presentation. Australian Professional Society on Alcohol and other Drugs (APSAD) Conference 8-11 November 2015, Perth Western Australia
  52. Seth D, Duly A, Huang E, McLennan S. Osteopontin plays a key role in alcohol and high fat diet induced liver injury. J Hepatol 2015, 62:S263-S864. Abstract P0931 at The International Liver Congress 2015 - 50th Annual meeting of the EASL, Vienna, Austria.

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE Total $$ Years
NHMRC Project Grant K Conigrave, K Lee, R Room, T Chikritzhs, N Hayman, D Gray, E Wilkes, S Wilson, S Callinan Better methods to collect self-report data on alcohol use behaviours from Aboriginal and Torres Strait Islander Australians.  $2,109,613.00 2015-2019
NHMRC Project Grant P Haber, K Morley, M Teeson, H Kranzler, M Shanahan, R Trent, A Baillie, N Luquin Defining the clinical role of topiramate in the treatment of alcohol dependence in Australia.  $   726,500.00 2015
BMCNeuroimaging Initiative Kirsten Morley Exploring the neurobehavioural basis of the baclofen, in the treatment of alcohol dependence.  $      8,758.80 2015
University SPARC Implementation (BMRI) Fund.   Pearson SA, Schneider C, Karanges E, McGregor I, Buckley NA, McLachlan A, Wilson F. From ‘BIG DATA’ to evidence: Post-market surveillance of psychotropic medicines in Australia.  $     49,700.00 2015
Royal Australasian College of Physicians Darren Roberts Jacquot Research Establishment Fellowship   $     90,000.00 2015
NHMRC Isbister GK, Buckley NA, DeSilva HJ, Brown SG, Hodgson W, Lalloo D, de Silva A, Dawson AH, Gawarammana I, Graudins A. Centre of Research Excellence in Translational venom and antivenom research. APP1110343  $     2,500,000 2015
Sydney Medical School New Staff/Early Career Researcher Scheme 2015 Bethany White Improving uptake of long acting contraceptive methods and reducing unplanned pregnancy in women in drug and alcohol health services: A pilot study assessing feasibility and acceptability  $     14,000.00 2015

Contact details for department

Head of Department: Professor Paul Haber

Department/Unit: Drug Health Services
Address:
RPA Hospital
Missenden Road
Camperdown NSW 2050
Telephone: (02) 9515 7611
Facsimile: (02) 9515 8970
Web: http://www.slhd.nsw.gov.au/research/
Email: abbie.white@sydney.edu.au