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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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PET/ Nuclear Medicine

Our Research

The Department of PET and Nuclear Medicine (Molecular Imaging - the 'Department') provides functional imaging using radioisotopes or tracers. The Department has had a number of 'first-in-country' landmarks. It was the first Department (of Nuclear Medicine) in the country and later with the Austin Hospital, in Melbourne, had the first PET scanners in the country in 1992. Later came the first 'fast scintillator' PET-CT scanner with Lutetium Oxyorthosilicate (LSO) PET detectors, the first 64-slice PET-CT and then 128-slice PET-CT scanners with time-of-flight (TOF) technology. In 2002, the Department installed the first public hospital owned and operated on-site medical cyclotron and associated radiochemistry facility in NSW. The cyclotron provides all the PET needs of the Department, which is the busiest and has performed the most scans in the country, and also supplies PET tracers to other metropolitan and rural public hospitals in NSW and Queensland. In January 2014, the Department became the first public hospital Department in Australia to obtain a Good Manufacturing Practice (GMP) PET Manufacturing license from the Therapeutic Goods Administration (TGA). The medical cyclotron is able to operate at very high beam currents permitting consistent and optimal isotope yields; it has maintained an outstanding 99.9% uptime with only 3 unscheduled 'down' days in 12 years of operation.

A hallmark of the Department has been its application of functional imaging to clinical care and patient management and its interactions with other medical and surgical specialties. In the pre-PET era cardiac nuclear medicine with its non-invasive capability to image the function of the heart has provided indispensable information for patient management. The introduction of PET heralded very strong collaborations with surgical oncologists - cardiothoracic, neurosurgical, upper gastrointestinal, colorectal, melanoma and orthopaedic surgeons - which pioneered the way that cancer was managed within Australia and internationally.

The radiochemistry facilities at the cyclotron has now enabled the production of new PET tracers for cancer and diseases of the nervous system, in particular, the neurodegenerative disorders such as the dementias. These tracers will be translated into clinical care in the coming years.

There is a strong track record for performing high quality basic science, animal, clinical and translational research, which is reflected in its continued success in achieving funding from peak granting bodies including the National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), and Cancer Institute of NSW. Staff have published in top medical, medical imaging and biomedical informatics journals as well as presenting research data at national and international meetings including the SNMMI, EANM, ANZSNM, MICCAI, EMBC, CARS, ISBI, ICARV, NSS/MIC, ISRS, CBMS, DICTA, VIP, SPIE-MI and MCBS. The Department is also actively involved in teaching and academic supervision of medical professionals, university students, postdoctoral fellows and it also conducts visits for high school students from all over NSW.

The Department has 2 identical 128-slice Siemens Biograph mCT scanners with time-of-flight (TOF) / high definition reconstruction and continuous bed motion, which have been validated for numerous national and international clinical trials, where the Department has also acted as a 'core' imaging lab. The Department has recently installed a SPECT-CT scanner. Autoradiography facilities have been set up to complement the development of new PET ligands. Plans are underway to purchase the next generation of functional/anatomical imaging, the PET-MR devices for use in animals and humans. The Department has successful research collaborations with individuals and groups at leading academic and research institutes including: University of Sydney (Institute of Biomedical Engineering and Technology (BMET) in the Faculty of Engineering and IT; the School of Chemistry; the Faculty of Pharmacology), University of New South Wales (Lowy Cancer Research Centre, School of Chemistry), University of Wollongong (School of Chemistry), Macquarie University (School of Advanced Medicine), Brain Mind and Research Institute (BMRI), Neuroscience Research Australia (NeuRA), Sendai/Chiba/Tohoku Universities in Japan, and the National Polytechnic University in Xi'an in China.

Awards/Medals

  • SNMMI 2015 International Best Abstract Award for Australia, Technologist Best Oral Abstract and Best PET Oral Abstract (2015) - Cui H, Wang X, Zhou J, Eberl S, Feng D, Fulham M. Improved segmentation accuracy for thoracic PET-CT in patients with NSCLC using a multi-graph model (MGM). 2015 Jun 6-10; Baltimore, MD, USA.
  • MCCAI 2015 CMMI Best Paper Award (2015) - Bi L, Kim J, Kumar A, Feng D, Fulham M. Adaptive supervoxel patch-based region classification in whole-body PET-CT. 2015 Oct 5-9; Munich, Germany.

Research Staff

  • Prof Michael Fulham
  • A/Prof Armin (Mohamed) Nikpour
  • Dr Kevin Allman
  • A/Prof Stefan Eberl
  • Mr Jordan Verscheur
  • Dr Lingfeng Wen
  • Dr Peng Gong
  • A/Prof Andrew Katsifis
  • Dr David Henderson
  • Dr Thomas Bourdier
  • Ms Filomena Mattner
  • Mr Peter Lam
  • Mr Jackson Poon
  • Mr Vu Le
  • Dr Thanh Le
  • Ms Alice Caldwell
  • Ms Patricia Knebl

Higher Degree Students:

PhD:

  • Mr Michael Yang
  • Mr Thomas Richardson-Sanchez


Publications and Presentations

Publication Details:
  1. Ahn E, Bi L, YH J, Jinman K, Changyang L, Fulham M, Feng D. Automated saliency-based lesion segmentation in dermoscopic images. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference (EMBC 2015). 2015 Aug 25-29; Milan, Italy; pp. 3009-3012.
  2. Huang R, Bi L, Li C, Jung Y, Kim J, Fulham M, Feng D. A locally constrained knowledge-based random walk approach for airway segmentation on low-contrast computed tomography (CT) images. International Conference on Digital Imaging Computing Techniques and Applications (DICTA 2015). 2015 Nov 23-25; Adelaide, Australia; pp. 1-7.
  3. Bi L, Kim J, Wen L, Feng D, Fulham M. Automated threshold region classification using a robust feature selection method for PET-CT. 12th IEEE International Symposium on Biomedical Imaging (ISBI 2015). 2015 Apr 16-29; New York, NY, USA; pp.1435-1438.
  4. Liu S, Cai W, Liu SQ, Zhang F, Fulham M, Feng D, Pujol S, Kikinis R. Multimodal Neuroimaging Computing: A review of the applications to neuropsychiatric disorders. Brain Informatics. 2015; 2(3):167-180. Review.
  5. Liu S, Cai W, Liu SQ, Zhang F, Fulham M, Feng D, Pujol S, Kikinis R. Multimodal Neuroimaging Computing: The workflows, methods and platforms. Brain Informatics. 2015; 2(3):181-195. Review.
  6. Cui H, Wang X, Zhou J, Eberl S, Yin Y, Feng D, Fulham M. Topology polymorphism graph for lung tumor segmentation in PET-CT images. Physics in Medicine and Biology. 2015; 60(12):4893-4914.
  7. Gnaneswaran S, Tandy B, Fulham MJ. Brown fat FDG uptake abolished by radiotherapy. Clinical Nuclear Medicine. 2015;40(5):437-438.
  8. Kao SC, Fulham M, Wong K, Cooper W, Brahmbhatt H, MacDiarmid J, Pattison S, Sagong JO, Huynh Y, Leslie F, Pavlakis N, Clarke S, Boyer M, Reid G, van Zandwijk N. A significant metabolic and radiological response after a novel targeted microRNA-based treatment approach in malignant pleural mesothelioma. American Journal of Respiratory and Critical Care Medicine. 2015;191(12):1467-1469.
  9. Kumar A, Nette F, Klein K, Fulham M, Kim J. A visual analytics approach using the exploration of multidimensional feature spaces for content-based medical image retrieval. IEEE Journal of Biomedical Health and Informatics. 2015;19(5):1734-1746.
  10. Li C, Wang X, Eberl S, Fulham M, Yin Y, Feng DD. Supervised variational model with statistical inference and its application in medical image segmentation. IEEE Transactions on Biomedical Engineering. 2015; 62(1):196-207.
  11. Liu S, Liu S, Cai W, Che H, Pujol S, Kikinis R, Feng D, Fulham MJ. Multi-modal neuroimaging feature learning for multi-class diagnosis of Alzheimer's Disease. IEEE Transactions on Biomedical Engineering. 2015; 62(4):1132-1140.
  12. Song Y, Cai W, Huang H, Zhou Y, Feng D, Wang Y, Fulham M, Chen M. Large margin local estimate with applications to medical image classification. IEEE Transactions on Medical Imaging. 2015;34(6):1362-1377.
  13. Mattner F, Quinlivan M, Greguric I, Pham T, Liu X, Jackson T, Berghofer P, Fookes CJR, Dikic B, Gregoire MC, Dolle F, Katsifis A. Radiosynthesis, in vivo biological evaluation, and imaging of brain lesions with [123I]-CLINME, a new SPECT tracer for the translocator protein. Disease Markers. 2015;Article ID 729698,11 pages.
  14. Callaghan PD, Wimberley CA, Rahardjo GL, Berghofer PJ, Pham TQ, Jackson T, Zahra D, Bourdier T, Wyatt N, Greguric I, Howell NR, Siegele R, Pastuovic Z, Mattner F, Loc'h C, Gregoire MC, Katsifis A. Comparison of in vivo binding properties of the 18-kDa translocator protein (TSPO) ligands [(18)F]PBR102 and [(18)]PBR111 in a model of excitotoxin-induced neuroinflammation. European Journal of Nuclear Medicine and Molecular Imaging. 2015;42(1):138-151.
  15. Amhaoul H, Hamaide J, Bertoglio D, Reichel SN, Verhaeghe J, Geerts E, Van Dam D, De Deyn PP, Kumar-Singh S, Katsifis A, Van Der Linden A, Staelens S, Dedeurwaerdere S. Brain inflammation in chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis. Neurobiology of Disease. 2015;82:526-539.
  16. Roberts MP, Nguyen V, Ashford ME, Berghofer P, Wyatt NA, Krause-Heuer AM, Pham TQ, Taylor SR, Hogan L, Jiang CD, Fraser BH, Lengkeek NA, Matesic L, Gregoire MC, Denoyer D, Hicks RJ, Katsifis A, Geguric I. Synthesis and in vivo evaluation of [123]Melanin-targeted agents. Journal of Medicinal Chemistry. 2015;58(5):6214-6224.
  17. Lengkeek NA, Roberts MP, Zhang L, I-Chieh JL, Fookes CJR, Dikic B, Herzog H, Katsifis A, Greguric I. Synthesis and binding affinity of fluorine containing NG-acyl and sulfonyl BIBP3226 derivatives: Ligands for the NPY Y1 receptor. Australian Journal of Chemistry. 2015; http://dx.doi:10.1079/CH15569.
  18. Knoppman AA, Wong CH, Stevenson RJ, Homewood J, Mohamed A, Somerville E, Eberl S, Wen L, Fulham M, Bleasel AF. The relationship between neuropsychological functioning and FDG-PET hypometabolism in intractable mesial temporal lobe epilepsy. Epilepsy & Behavior. 2015;44C:136-14.
  19. Thayer Z, Wong C, Mohamed A, Miller L. Improving Memory in Patients with Epilepsy: Considering the Impact of Anti-Epileptic Drugs, Low Mood and/or Surgery on Memory Training Program Outcomes. International Journal of Neurorehabilitation. 2015;1(139). 1. doi:10.4172/2376-0281.1000139.
  20. Miller LA, Flanagan E, Mothakunnel A, Mohamed A, Thayer Z. Old dogs with new tricks: Detecting accelerated long-term forgetting by extending traditional measures. Epilepsy & Behavior. 2015;45:205-211.
  21. Gandy M, Sharpe L, Perry KN, Miller L, Thayer Z, Boserio J, Mohamed A. Anxiety in epilepsy: a neglected disorder. Journal of Psychosomatic Research. 2015;78(2):149-155.
  22. Hardy TA, Beadnall HN, Sutton IJ, Mohamed A, Jonker BP, Buckland ME, Barnett MH. Balo's concentric sclerosis and tumefactive demyelination: a shared immunopathogenesis? Journal of the Neurological Sciences. 2015;348(1-2):279-281.
  23. Ricci M, Mohamed A, Savage G, Boserio J, Miller LA. The impact of epileptiform abnormalities and hippocampal lesions on retention of recent autobiographical experiences: Adding insult to injury? Neuropsychologia. 2015;66:259-266.
  24. Ricci M, Mohamed A, Savage G, Miller LA. Disruption of learning and long-term retention of prose passages in patients with focal epilepsy. Epilepsy & Behaviour. 2015;51:104-111.
  25. Jung Y, Kim J, Fulham M, Feng DD. Volume rendering augmentation on slice of interest (SOI) for visualisation of thoracic PET-CT. International Journal of Computer Assisted Radiology and Surgery. 2015;10(Suppl 1):S194-195.
  26. Bi L, Kim J, Feng DD, Fulham M. Automated regions of interest (ROIs) tracking for PET-CT image series using cellular automata segmentation. International Journal of Computer Assisted Radiology and Surgery. 2015;10(Suppl 1):S21-22.
  27. Cui H, Wang X, Zhou J, Eberl S, Feng D, Fulham M. Improved segmentation accuracy for thoracic PET-CT in patients with NSCLC using a multi-graph model (MGM). Journal of Nuclear Medicine. 2015;56(Suppl 3):2527 • SNMMI 2015 award winning submission.
  28. Song Y, Cai W, Zhou Y, Feng D, Fulham M. Lesion detection with extremal regions in thoracic PET-CT images. Journal of Nuclear Medicine. 2015; 56(Suppl 3):1783.
  29. Mattner F, Hung T-T, Bourdier T, Lee B, Henderson D, Poon J, Doan J, Power C, Katsifis A, Fulham M. Evaluation of 18F-TSPO radiotracers in a prostate tumour model using PET. Journal of Nuclear Medicine. 2015; 56(Suppl 3):555.
  30. Asih PR, Ji B, Katsifis A, Mattner F, Caruso D, Melcangi RC, Higuchi M, Martins RN, Barron AM. In vivo evaluation of the therapeutic potential of novel translocator protein (TSPO) ligands for the treatment of Alzheimer's disease. Alzheimer's & Dementia. 2015;11(7, Suppl):P156-157.

Presentations:

International:

  1. Bi L, Kim J, Wen L, Feng D, Fulham M (2015, Apr). Automated threshold region classification using a robust feature selection method for PET-CT. 12th IEEE International Symposium on Biomedical Imaging (ISBI 2015). 2015 Apr 16-29; New York, NY, USA.
  2. Fulham M (2015, Apr). Shanghai Jiao Tong University & The University of Sydney Joint Research Alliance, Clinical Medical Imaging and Informatics Workshop. 2015 Apr 20; SJTU School of Medicine, Shanghai, China.
  3. Katsifis A (2015, May). 18F-Fluoride and nucleophilic aliphatic substitutions. International Symposium on Radiopharmaceutical Sciences (ISRS 2015) Pre-Symposium Workshop. 2015 May 26; Columbia, MO, USA.
  4. Cui H, Wang X, Zhou J, Eberl S, Feng D, Fulham M (2015, Jun) A. Improved segmentation accuracy for thoracic PET-CT in patients with NSCLC using a multi-graph model (MGM). Society of Nuclear Medicine and Molecular Imaging Annual Meeting 2015 (SNMMI 2015). 2015 Jun 6-10; Baltimore, MD, USA. *award winning submission
  5. Mattner F, Hung T-T, Bourdier T, Lee B, Henderson D, Poon J, Doan J, Power C, Katsifis A, Fulham M (2015, Jun). Evaluation of 18F-TSPO radiotracers in a prostate tumour model using PET. Society of Nuclear Medicine and Molecular Imaging Annual Meeting 2015 (SNMMI 2015). 2015 Jun 6-10; Baltimore, MD, USA.
  6. Song Y, Cai W, Zhou Y, Feng D, Fulham M (2015, Jun). Lesion detection with extremal regions in thoracic PET-CT images. Society of Nuclear Medicine and Molecular Imaging Annual Meeting 2015 (SNMMI 2015). 2015 Jun 6-10; Baltimore, MD, USA.
  7. Asih PR, Ji B, Katsifis A, Mattner F, Caruso D, Melcangi RC, Higuchi M, Martins RN, Barron AM (2015, Jul). In vivo evaluation of the therapeutic potential of novel translocator protein (TSPO) ligands for the treatment of Alzheimer's disease. Alzheimer's Association International Conference 2015 (AAIC 2015). 2015 Jul 18-23; Washington, DC, USA.
  8. Ahn E, Bi L, YH J, Jinman K, Changyang L, Fulham M, Feng D (2015, Aug). Automated saliency-based lesion segmentation in dermoscopic images. 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Conference (EMBC 2015). 2015 Aug 25-29; Milan, Italy.
  9. Mattner F, Hung TT, Bourdier T, Lee BJ, Henderson D, Poon J, Doan J, Lam P, Power C, Eberl S, Katsifis A, Fulham M (2015, Sep). Evaluation of the TSPO radiotracer 18F-PBR316 in prostate tumour models. World Molecular Imaging Congress 2015 (WMIC 2015). 2015 Sep 2-5; Honolulu, HI, USA.
  10. Fulham M (2015, Sep). IT and Healthcare. International Workshop on Biomedical and Multimedia Computing. 2015 Sep 22. National Polytechnical University (NPU); Xi'an, China.
  11. Bi L, Kim J, Kumar A, Feng D, Fulham M (2015, Oct). Adapative supervoxel patch-based region classification in whole-body PET-CT. 18th Medical Image Computing & Computer Assisted Intervention (MICCAI 2015) - Computational Methods for Molecular Imaging (CMMI) Workshop. 2015 Oct 5-9; Munich, Germany. *award winning submission
  12. Huang R, Bi L, Li C, Jung Y, Kim J, Fulham M, Feng D (2015, Nov). A locally constrained knowledge-based random walk approach for airway segmentation on low-contrast computed tomography (CT) images. International Conference on Digital Imaging Computing Techniques and Applications (DICTA 2015). 2015 Nov 23-25; Adelaide, Australia.

National:

  1. Allman K (2015). Adenosine Sestamibi patient outcomes. Cardiology Lecture Series. John Greenaway meeting room, RPA, Sydney, Australia.
  2. Allman K (2015). Use of CTCA in Emergency Departments. Cardiology Lecture Series. John Greenaway meeting room, RPA, Sydney, Australia.
  3. Fulham M (2015, Feb). Panel discussion. Separating fact from fiction ex vivo and in vivo neuropathology in ALS. 2015 Feb 16; Brain and Mind Centre, Sydney, Australia.
  4. Fulham M (2015, May). 3 scans to identify problem 'forgetting'. Sydney Research and Innovation Symposium. 2015 May 29; Australian Technology Park, Sydney, Australia.
  5. Fulham M (2015, Oct). Developments in functional imaging and PET tracers and SLHD Medical Imaging - looking ahead. SLHD Imaging Think Tank. 2015 Oct 13. RPA, Sydney, Australia.

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE Total $$ Years
ARC - Linkage Project Grant Feng DD, Kim J, Fulham MJ, Eberl S OMNI–Modality Medical Image Analysis and Visualisation  $355,000 2014-2017
ARC - Discovery Project Grant Feng DD, Fulham MJ, Eberl S An integrated virtual functional human body (VFHB)  $342,000 2014-2016
NHMRC - Project Grant Gandhi M, Fulham M, Trotman J, Berkahn L, Le Cao K, Jones K Circulating biomarkers in advanced classical Hodgkin lymphoma. NHMRC Project Grant  $513,447 2014-2016
Prostate Foundation of Australia -Equipment Grant  Katsifis A, Power C, Eberl S, Mattner F, Fulham MJ, Bourdier T, Henderson D, Lam P Development and evaluation of novel TSPO radiotracers for imaging prostate cancer using positron emission tomography  $300,000 2013-2015

Contact details for department

Head of Department: Professor Michael Fulham

Department/Unit: PET/ Nuclear Medicine
Address:
Other
Department of Molecular Imaging (PET and Nuclear Medicine), Level A7, Building 63, Royal Prince Alfred Hospital, Missenden Road
Camperdown NSW 2050
Telephone: (02) 9515 7908
Facsimile: (02) 9515 8690
Web: http://www.slhd.nsw.gov.au/research/
Email: patricia.knebl@sswahs.nsw.gov.au