Ò NEUROPATHOLOGY – Molecular Request Form (Version 6.0) (updated 03/07/2023)
Effective from 1 July 2023, some of the molecular diagnostic tests offered are included in the Medicare Benefit Scheme (MBS) for eligible patients.
Next Generation Sequencing (NGS) Glioma Panel
The Next Generation Sequencing (NGS) glioma panel provides NATA accredited service for the assessment of relevant glioma-associated molecular alterations.
As of 1 July 2023, our NGS glioma panel is fully covered under the MBS for eligible patients (MBS
Additional genes are in the process of validation for NATA accreditation. Once accredited they will be added to our NATA accredited panel targets. At present, the results of the unaccredited component can only be released on request as “research use only” results, and cannot be used for clinical decision making.
- MGMT promoter methylation
- IDH1/2 pyrosequencing
Methylation Profiling of Central Nervous System Tumours
Ò NEUROPATHOLOGY – Methylation Profiling Request Form (Version 1.1) (updated 28/10/2021)
As various tumours have shown distinctive patterns of CpG island methylation, Methylation Profiling of Central Nervous System Tumours service is based on the Illumina Infinium MethylationEPIC 850K array which interrogates 850,000 methylation sites across the genome. An algorithm for DNA methylation-based classification of central nervous system tumours has been developed by the German Cancer Research Center (DKFZ) / Heidelberg University Hospital (www.molecularneuropathology.org/mnp). The algorithm is based on a tumour reference cohort of over 2,800 cases. The algorithm version is periodically updated. (Please see reference: Capper D et al Nature (2018) PMID 29539639 for background information).
This is a non-NATA accredited test. The non-accredited results will be reported as “Research Use Only” results with the following disclaimer: “Classification using methylation profiling is a research tool under development, it is not verified and has not been clinically validated. Implementation of the results in the clinical setting is in the sole responsibility of the treating physician.”
The cost of the test is $1000. There is currently no Medicare rebate for this test. The turnaround time is 6-8 weeks from receipt of the specimen. Please note that this test requires a FFPE tissue block with at least 80% tumour cellularity to be sent for optimal test performance.