Sydney Local Health District
Our Research

Centre for Education and Research on Ageing (CERA)

Our Research

The Centre for Education and Research on Ageing (CERA) and its members undertake basic science, epidemiological and clinical research. CERA is part of the Department of Geriatric Medicine at Concord Hospital. CERA is a multidisciplinary hub to foster collaboration between clinical and academic health professionals and facilitate the translation of research findings into clinical practice. The research objectives of CERA are:

  • To improve the health and productivity of older people through research into the ageing process.
  • To improve the well-being and quality of life of older people, especially those with frailty or dementia, through research into health care.
  • To provide leadership in the education and training of people involved in the care of older people and those involved in ageing research.

Current research programs include:

  • Oral Health
  • Ageing liver and nanomedicines
  • Novel mechanisms for dementia
  • Surgical liaison and older people in hospital
  • Advanced care directives
  • Polypharmacy and deprescribing
  • Identification and management of delirium in older inpatients
  • Falls prevention in hospital
  • Geriatric Medicine Services in Australia and New Zealand
  • Emergency Hospital in the Home.

Key Achievements

  • The Biogerontology group continues to explore the targeted use of medicines and other therapeutics. The group is collaborating with the Institut d'Investigacions Biomèdiques in Barcelona in the use of our nanotechnology for microRNA delivery for the prevention of liver failure.
  • Dr Nicholas Hunt has been awarded a SOAR fellowship through the University of Sydney and has published key findings in ACS Nano using our nanotechnology platform.
  • CERA led a study on the teaching of Geriatric medicine at medical schools in Australia. This data was provided to the Royal Commission into Aged care Quality and Safety who were interested in knowing more about this. CERA members also contributed submissions.
  • A new perioperative model of care has been adopted by the Sydney Local Health District based on research conducted by CERA PhD students Dr Sarah Aitken and Dr Janani Thillainadesan.
  • COVID-19: Numerous CERA members had key advisory roles during the height of the COVID-19 epidemic, through participation in various national / State / local taskforces and advisory bodies.
  • Janani Thillainadesan awarded ANZSGM Career Investigator Prize and UK Age Anaesthesia Association Annual Scientific Meeting (ASM) Best Oral Presentation Prize in 2021.
  • Deborah Cockrell has been appointed a Member (AM) in the General Division of the Order of Australia for her significant service to dentistry, profession organisation and to education.
  • CERA/Geriatric Medicine Outreach-OHT, Integrating Oral Health in Residential Care Program won both the SLHD 2018 Quality Award in the "Delivering Integrated Care" Category and the 2018 Chairman's Award.
  • Nicholas Hunt was awarded the "Distinction in Scholarship" by the American Journal of Physiology for his publication in the journal.
  • PhD students submitted and/or graduated: Janani Thillainadesan, Sarah Aitken. Jennifer Gibney, Naomi Noguchi, Devin Wahl, Rahul Gokarn, Sun Woo Sophie Kan.
  • Current Masters (MPhil) students: Dr Eleni Azarias, Dr Atul Wagh, Dr Bethany Stavert, Dr Joshua Makary.
  • Sachiko Takehara Endeavour Fellowship from Japan to collaborate with Oral Health Programme and CHAMP.

Awards/Medals

  • Nicholas Hunt has been awarded a SOAR fellowship through the University of Sydney.
  • Janani Thillainedesan awarded ANZSGM Career Investigator Prize and UK Age Anaesthesia Association Annual Scientific Meeting (ASM) Best Oral Presentation Prize in 2021
  • Deborah Cockrell has been appointed a Member (AM) in the General Division of the Order of Australia for her significant service to dentistry, profession organisation and to education.
  • CERA/Geriatric Medicine Reach-OHT, Integrating Oral Health in Residential Care Program won both the SLHD 2018 Quality Award in the "Delivering Integrated Care" Category and the 2018 Chairman's Award.

Research Staff

CERA Co-Directors
Professor Vasi Naganathan: Professor of Geriatric Medicine, University of Sydney / Consultant Geriatrician, Concord Hospital
Professor Victoria Cogger: Associate Dean (Research Education), The University of Sydney / Co-leader Biogerontology laboratory.

Department of Geriatric Medicine, Concord Hospital
Professor Vasi Naganathan: Consultant Geriatrician
Professor David Le Couteur: Senior Staff Specialist in Geriatric Medicine; Professor of Geriatric Medicine, The University of Sydney.
Clinical Associate Professor John Cullen: Stream Director SLHD Aged Health Care, Rehabilitation, General Medicine, Chronic Care, Disability, Endocrinology, Andrology and Ambulatory Care / Clinical Associate Professor, Concord Clinical School, The University of Sydney
Clinical Associate Professor Louise Waite: Senior Staff Specialist Geriatrician. Head of Department of Geriatric Medicine / Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Janani Thillainadesan: Staff Specialist Geriatrician / Conjoint Lecturer, Concord Clinical School, University of Sydney
Clinical Associate Professor Deborah Cockrell: Lead for Oral Health, CERA / Clinical Associate Professor, Concord Clinical School, University of Sydney
Dr Natasha Spalding: Staff Specialist Geriatrician / Director of RACF Outreach Service.
Dr Cameron Korb-Wells: Geriatrician
Dr Virginia Painter: Geriatrician
Dr Alice Minchin: Advanced Trainee
Dr George Wells: Advanced Trainee
Dr Nadine Elias: Advanced Trainee
Dr Kate Djekovic: Advanced Trainee
Mr Steven Chu: Oral Health PhD student

Biogerontology Lab, ANZAC Research Institute, Concord Hospital
Professor Victoria Cogger: Co-leader Biogerontology laboratory
Professor David Le Couteur: Co-leader Biogerontology laboratory
Dr Nicholas Hunt: Post-doctoral researcher
Glen Lockwood: Lab Manager
Ms Lara Westwood: PhD Candidate

CERA Research Support Staff
Leanne Kearney, CERA Research Project Officer
Sarita Lo, CERA Research Pharmacist
Anne Warby, CERA Support Manager

Higher Degree Students:

Completed PhD                    
Janani Thillainadesan
Sarah Aitken
Rahul Gokarn
Devin Wahl
Sun Woo Sophie Kang
Jennifer Gibney
Naomi Noguchi

Current PhD
Lara Westwood
Winston Cheung
Glen Lockwood
Steven Chu
Charlotte McLennan
Jenna Smith

Current Masters (MPhil)
Eleni Azarias
Atul Wagh
Bethany Stavert
Joshua Makary



Publications and Presentations

Publication Details:
  1. Baysari MT, Duong M, Zheng WY, Nguyen A, Lo S, Ng B, Ritchie A, Le Couteur D, McLachlan A, Bennett A, Hilmer S. Delivering the right information to the right person at the right time to facilitate deprescribing in hospital: a mixed methods multisite study to inform decision support design in Australia. BMJ open. 2019;9(9):e030950. 10.1136/bmjopen-2019-030950
  2. Naganathan V., Nagaratnam K. Managing Osteoporosis in Oldest of Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 217-221. doi.org/10.1007/978-3-319-96998-5
  3. Naganathan V. Prescribing to the Oldest Old. In: Nagaratnam N., Nagaratnam K., Cheuk G., editors. Advanced Age Geriatric Care: A Comprehensive Guide. Springer, Cham; 2019. p 297-304. doi.org/10.1007/978-3-319-96998-5
  4. Gaddam RR, Chambers S, Fraser R, Cogger VC, Le Couteur DG, Ishii I, Bhatia M. Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis. International journal of molecular sciences. 2019;20(13). 10.3390/ijms20133191
  5. Gibney JM, Wright FA, D'Souza M, Naganathan V. Improving the oral health of older people in hospital. Australasian journal on ageing. 2019 Mar;38(1):33-38. doi: 10.1111/ajag.12588
  6. Hsu B, Hirani V, Cumming RG, Naganathan V, Blyth FM, Wright FC, Waite LM., Seibel MJ., Handelsman DJ., Le Couteur DG.. Cross-Sectional and Longitudinal Relationships Between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):835-41. 10.1093/gerona/glx142
  7. Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC. Hallmarks of Aging in the Liver. Computational and structural biotechnology journal. 2019;17:1151-61. 10.1016/j.csbj.2019.07.021
  8. Hunt NJ, Lockwood GP, Warren A, Mao H, McCourt PAG, Le Couteur DG, Cogger V. Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American journal of physiology Gastrointestinal and liver physiology. 2019;316(1):G144-g54. 10.1152/ajpgi.00179.2018
  9. Jokanovic N, Aslani P, Carter S, Duong M, Gnjidic D, Jansen J, Le Couteur D, Hilmer S. Development of consumer information leaflets for deprescribing in older hospital inpatients: a mixed-methods study. BMJ open. 2019;9(12):e033303. 10.1136/bmjopen-2019-033303
  10. Kang SWS, Cogger VC, Le Couteur DG, Fu D. Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American journal of physiology Cell physiology. 2019;317(5):C942-c52. 10.1152/ajpcell.00051.2019
  11. Kashyap M, Thuermann P, Le Couteur DG, Abernethy DR, Hilmer SN. IUPHAR International geriatric clinical pharmacology curriculum for medical students. Pharmacological research. 2019;141:611-5. 10.1016/j.phrs.2019.01.032
  12. Koay YC, Wali JA, Luk AWS, Macia L, Cogger VC, Pulpitel TJ, Wahl D, Solon-Biet SM, Holmes A, Simpson SJ, O'Sullivan JF. Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019;33(7):8033-42. 10.1096/fj.201900177R
  13. Mach J., Huizer-Pajkos A., Cogger V., McKenzie C., Le Couteur D., de Cabo R., Jones B., Hilmer S.. Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(3):332. 10.1093/gerona/gly160
  14. Mao H, Diekmann R, Liang HPH, Cogger VC, Le Couteur DG, Lockwood GP, Hunt NJ, Schüttpelz M, Huser TR, Chen VM and McCourt PAG. Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets. Nanophotonics;8(7): 1299-1313. doi.org/10.1515/nanoph-2019-0066
  15. Maeso-Díaz R, Ortega-Ribera M, Lafoz E, Lozano JJ, Baiges A, Francés R, Albillos A, Peralta C, García-Pagán JC, Bosch J, Cogger VC, Gracia-Sancho J. Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease. Aging and disease. 2019;10(4):684-98. 10.14336/AD.2019.0127
  16. Morimoto J., Senior A., Ruiz K., Wali J., Pulpite, T., Solon-Biet S., Cogger V., Raubenheimer D., Le Couteur D., Simpson S., Eberhard J.. Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS one. 2019;14(3):e0212796. 10.1371/journal.pone.0212796
  17. Moth, E., Kiely, B., Stefanic, N., Naganathan, V., Martin, A., Grimison, P., Stockler, M., Beale, P., Blinman, P.. Oncologists' perceptions on the usefulness of geriatric assessment measures and the CARG toxicity score when prescribing chemotherapy for older patients with cancer. Journal of geriatric oncology. 2019;10(2):210-5. 10.1016/j.jgo.2018.11.004
  18. Moth EB, Kiely BE, Stefanic N, Naganathan V, Martin A, Grimison P, StocklerMR, Beale P, Blinman P. Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. Journal of geriatric oncology. 2019;10(2):202-9. 10.1016/j.jgo.2018.08.010
  19. Narayan SW, Pearson SA, Litchfield M, Le Couteur DG, Buckley N, McLachlan AJ, Zoega H. Anticholinergic medicines use among older adults before and after initiating dementia medicines. British journal of clinical pharmacology. 2019;85(9):1957-63. 10.1111/bcp.13976
  20. Rhee J, Meller A, Krysinska K, Gonski P, Naganathan V, Zwar N, Hayen A, Cullen J, O’Keefe JA, McDonald J, Harris-Roxas B, Caplan GA. Advance care planning for patients with advanced illnesses attending hospital outpatient clinics study: a study protocol for a randomised controlled trial. BMJ open. 2019;9(1):e023107. 10.1136/bmjopen-2018-023107
  21. Ribeiro R.V., Solon-Biet S.M., Pulpitel T., Senior A.M., Cogger V.C., Clark X., O’Sullivan J., Koay Y.C., Hirani V., Blyth F.M., Seibel M.J., Waite L.M., Naganathan V., Cumming R.G., Handelsman D.J., Simpson S.J., Couteur D.G.L. Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition. Nutrients. 2019;11(8). 10.3390/nu11081882
  22. Ribeiro RV, Simpson SJ, Le Couteur DG, Raubenheimer D, Eberhard J, Ruiz K, Macia L, Todorova Y, Gosby AK. The nutrition for healthy living study: A randomised clinical trial assessing the effect of protein sources on healthy ageing Nutrition and Healthy Aging 2019;5(1): 43-51. 10.3233/NHA-180055
  23. Scott, D., Seibel M., Cumming R., Naganathan V., Blyth F., Le Couteur D., Handelsman D., Waite L., Hirani V. Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(6):827-34. 10.1093/gerona/gly162
  24. Scott IA, Hilmer SN, Le Couteur DG. Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients. Drugs & aging. 2019;36(8):675-85. 10.1007/s40266-019-00683-8
  25. Senior AM, Solon-Biet SM, Cogger VC, Le Couteur DG, Nakagawa S, Raubenheimer D, Simpson SJ. Dietary macronutrient content, age-specific mortality and lifespan. Proceedings Biological sciences. 2019;286(1902):20190393. 10.1098/rspb.2019.0393
  26. Shu CC, Hsu B, Cumming RG, Blyth FM, Waite LM, Le Couteur DG, Handelsman DJ, Naganathan V. Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project. Age and ageing. 2019;48(4):571-6. doi.org/10.1093/ageing/afz039
  27. Simpson SJ, Le Couteur DG. The diet and the damage done. Nature metabolism. 2019;1(11):1030-1. 10.1038/s42255-019-0128-6
  28. Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature metabolism. 2019;1(5):532-45. 10.1038/s42255-019-0059-2
  29. Solon-Biet SM, Wahl D, Raubenheimer D, Cogger V., Le Couteur DG, Simpson SJ. The geometric framework: An approach for studying the impact of nutrition on healthy aging. Drug Discovery Today: Disease Models 2019; 27; 61-68. doi.org/10.1016/j.ddmod.2019.03.002
  30. Thillainadesan J, Hilmer SN, Close J, Kearney L, Naganathan V Geriatric medicine services for older surgical patients in acute hospitals: Results from a binational survey Australasian Journal on Ageing 2019; 38(4):278-283. 10.1111/ajag.12675
  31. Johnson G, Byun R, Foster K, Wright F, Blinkhorn A. A longitudinal workforce analysis of a Rural Clinical Placement Program for final year dental students. Australian Dental Journal. 2019 Jun;64(2):181-192. doi: 10.1111/adj.12691. PMID: 30929266.
  32. Thomas R, Sims R, Beller E, Scott A., Doust J, Le Couteur DG, Pond D, Loy C, Forlini C., Glasziou P. An Australian community jury to consider case-finding for dementia: Differences between informed community preferences and general practice guidelines. Health Expectations, 2019 22(3), 475-484. 10.1111/hex.12871
  33. Toyama T, van den Broek-Best O, Ohkuma T, Handelsman D, Waite LM, Seibel MJ, Cumming R, Naganathan V, Sherrington C, Hirani V, Wang AY. Associations of Impaired Renal Function With Declines in Muscle Strength and Muscle Function in Older Men: Findings From the CHAMP Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2019;74(11):1812-20. 10.1093/gerona/glz100
  34. Tran J, Wright FAC, Takehara S, Chu C-C, Naganathan V., Hirani V., Blyth FM, Le Couteur DG, Waite L, Handelsman DJ, Seibel M, Milledge K, Cumming RG. Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project. Australian dental journal. 2019;64(3):246-55. 10.1111/adj.12694
  35. Wahl D, Gokarn R, Mitchell SJ, Solon-Biet SM, Cogger VC, Simpson SJ, Le Couteur DG., de Cabo R. Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and healthy aging. 2019;5(2):111-7. 10.3233/NHA-180059
  36. Wahl D, Solon-Biet SM, Cogger VC, Fontana L, Simpson SJ, Le Couteur DG, Ribeiro RV. Aging, lifestyle and dementia. Neurobiology of disease. 2019;130:104481. 10.1016/j.nbd.2019.104481
  37. Weir KR, Bonner C, McCaffery K, Naganathan V, Carter SM, Rigby D, Trevena L, Mclachlan A, Jansen J. Pharmacists and patients sharing decisions about medicines: Development and feasibility of a conversation guide. Research in social & administrative pharmacy : RSAP. 2019;15(6):682-90. 10.1016/j.sapharm.2018.08.009
  38. Weir KR, Naganathan V, Rigby D, McCaffery K, Bonner C, Trevena L, McLachlan A, Jansen J. Home medicines reviews: a qualitative study of GPs’ experiences. Australian journal of primary health. 2019;26(1) 24-30 https://doi.org/10.1071/PY19072.
  39. Wright FAC, Law GG, Milledge KL, Chu SK, Hsu B, Valdez E, Naganathan V, Hirani V, Blyth FM, LeCouteur DG, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Chewing function, general health and the dentition of older Australian men: The Concord Health and Ageing in Men Project. Community dentistry and oral epidemiology. 2019;47(2):134-41. 10.1111/cdoe.12435
  40. Aitken SJ, Randall DA, Noguchi N, Blyth FM, Naganathan V. Multiple Peri-Operative Complications are Associated with Reduced Long Term Amputation Free Survival Following Revascularisation for Lower Limb Peripheral Artery Disease: A Population Based Linked Data Study. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 2020;59(3):437-45. 10.1016/j.ejvs.2019.11.014
  41. Bernier M, Harney D, Koay YC, Diaz A, Singh A, Wahl D, Pulpitel T, Ali A, Guiterrez V, Mitchell SJ, Kim EY, Mach J, Price NL, Aon MA, LeCouteur DG, Cogger VC, Fernandez-Hernando C, O'Sullivan J, Larance M, Cuervo AM, de Cabo R. Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ aging and mechanisms of disease. 2020;6:8. 10.1038/s41514-020-0046-6
  42. Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell metabolism. 2020. 32(2), 203-214.e4. 10.1016/j.cmet.2020.04.019
  43. Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, Bustamante S, Li C, Zhao Y, Marinova MB, Kim LJ, Lau L, Wu RM, Mikolaizak AS, Araki T, Le Couteur DG, Turner N, Morris MJ, Walters KA, Goldys E, O'Neill C, Gilchrist RB, Sinclair DA, Homer HA, Wu LE. NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell reports. 2020;30(6):1670-81.e7. 10.1016/j.celrep.2020.01.058
  44. Cervo MMC, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Shivappa N, Hebert JR, Hirani V. Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. The Journal of nutrition. 2020;150(2):373-81. 10.1093/jn/nxz256
  45. Das A, Cumming RG, Naganathan V, Blyth F, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Simpson SJ, Hirani V. Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):348-56. 10.1093/gerona/glz054
  46. Ford GA, Lord JM, Ferguson MAJ, Bountra C, Le Couteur DG. Organizational Innovation for Developing New Medicines That Target Aging and Age-Related Conditions. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(1):87-8. 10.1093/gerona/glz062
  47. Freire T, Senior AM, Perks R, Pulpitel T, Clark X, Brandon AE, Wahl D, Hatchwell L, Le Couteur DG, Cooney GJ, Larance M, Simpson SJ, Solon-Biet SM. Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. The Journal of physiology. 2020;598(11):2081-92. 10.1113/JP278806
  48. Gnanenthiran SR, Ng ACC, Cumming R, Brieger DB, Le Couteur D, Waite L, Handelsman D, Naganathan V, Kritharides L, Blyth F. Low total cholesterol is associated with increased major adverse cardiovascular events in men aged ≥70 years not taking statins. Heart (British Cardiac Society). 2020;106(9):698-705. 10.1136/heartjnl-2019-315449
  49. Handelsman DJ, Desai R, Seibel MJ, Le Couteur DG, Cumming RG. Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage. The Journal of steroid biochemistry and molecular biology. 2020;197:105528. 10.1016/j.jsbmb.2019.105528
  50. Hew JJ, Parungao RJ, Tsai KH, Shi H, Ma D, Nicholls C, Li Z, Solon-Biet SM, D'Souza M, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice. The British journal of nutrition. 2020;123(9):1056-67. 10.1017/S0007114520000276
  51. Hide D, Warren A, Fernández-Iglesias A, Maeso-Díaz R, Peralta C, Le Couteur DG, Bosch J, Cogger VC, Gracia-Sancho J. Ischemia/Reperfusion Injury in the Aged Liver: The Importance of the Sinusoidal Endothelium in Developing Therapeutic Strategies for the Elderly. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):268-77. 10.1093/gerona/glz012
  52. Hsu B, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men. The journal of nutrition, health & aging. 2020;24(6):563-9. 10.1007/s12603-020-1352-1
  53. Hubbard RE, Maier AB, Hilmer SN, Naganathan V, Etherton-Beer C, Rockwood K. Frailty in the face of COVID-19. Age and ageing. 2020;49(4):499-500. 10.1093/ageing/afaa095
  54. Hunt NJ, Lockwood GP, Kang SWS, Pulpitel T, Clark X, Mao H, McCourt PAG, Cooney GJ, Wali JA, Le Couteur FH, Le Couteur DG, Cogger VC. The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(2):278-85. 10.1093/gerona/glz153
  55. Hunt NJ, Lockwood GP, Le Couteur FH, McCourt PAG, Singla N, Kang SWS, Burgess A, Kuncic Z, Le Couteur DG, Cogger VC. Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. ACS nano. 2020;14(2):1492-507. 10.1021/acsnano.9b06071
  56. Khalatbari-Soltani S, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Seibel MJ, Waite LM, Cvejic E, Cumming RG. Socioeconomic status, health-related behaviours, and death among older people: the Concord health and aging in men project prospective cohort study. BMC geriatrics. 2020;20(1):261. 10.1186/s12877-020-01648-y
  57. Le Couteur DG, Anderson RM, Newman AB. COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 16;75(9):e119-e120. 10.1093/gerona/glaa077
  58. Le Couteur DG, Anderson RM, Newman AB. Erratum to: COVID-19 Through the Lens of Gerontology. The journals of gerontology Series A, Biological sciences and medical sciences. 2020. doi.org/10.1093/gerona/glaa080
  59. Le Couteur DG, Stanaway F, Waite LM, Cullen J, Lindley RI, Blyth FM, Naganathan V, Cumming RG, Handelsman DJ. Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1858-1862. 10.1093/gerona/glaa105
  60. Le Couteur DG, Ribeiro R, Senior A, Hsu B, Hirani V, Blyth FM, Waite LM, Simpson SJ, Naganathan V, Cumming RG, Handelsman DJ. Branched chain amino acids, cardiometabolic risk factors and outcomes in older men: the Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Sep 25;75(10):1805-1810. 10.1093/gerona/glz192
  61. Li J, Zhao Y, Choi J, Ting KK, Coleman P, Chen J, Cogger VC, Wan L, Shi Z, Moller T, Zheng X, Vadas MA, Gamble JR. Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. PLoS biology. 2020;18(6):e3000734. 10.1371/journal.pbio.3000734
  62. Moth EB, Blinman P, Stefanic N, Naganathan V, Grimison P, Stockler MR, Beale P, Martin A, Kiely BE. Estimating survival time in older adults receiving chemotherapy for advanced cancer. Journal of geriatric oncology. 2020;11(4):617-25. 10.1016/j.jgo.2019.08.013
  63. Moth EB, Kiely BE, Martin A, Naganathan V, Della-Fiorentina S, Honeyball F, Zielinski R, Steer C, Mandaliya H, Ragunathan A, Blinman P. Older adults' preferred and perceived roles in decision-making about palliative chemotherapy, decision priorities and information preferences. Journal of geriatric oncology. 2020;11(4):626-32. 10.1016/j.jgo.2019.07.026
  64. Ortega-Ribera M, Hunt NJ, Gracia-Sancho J, Cogger VC. The Hepatic Sinusoid in Aging and Disease: Update and Advances From the 20th Liver Sinusoid Meeting. Hepatology communications. 2020;4(7):1087-98. 10.1002/hep4.1517
  65. Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men. Bone. 2020;137:115433. 10.1016/j.bone.2020.115433
  66. Scott D, Seibel MJ, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Hsu B, Waite LM, Hirani V. Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. The journals of gerontology Series A, Biological sciences and medical sciences. 2020;75(5):939-45. 10.1093/gerona/glz184
  67. Simpkins DM, Hohenberg MI, Naganathan V, White K. Help, I'm a specialist! Perspectives of recently qualified geriatricians on the experiences and challenges of working as a consultant geriatrician. Australasian journal on ageing. 2020;39(1):73-80. 10.1111/ajag.12670
  68. Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ. Published Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell metabolism. 2020;31(3):654. 10.1016/j.cmet.2020.01.010
  69. Stanaway FF, Blyth FM, Naganathan V, Le Couteur DG, Ribeiro R, Hirani V, Waite LM, Handelsman DJ, Seibel MJ, Cumming RG. Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project. Journal of immigrant and minority health. 2020;22(1):102-9. 10.1007/s10903-019-00874-w
  70. Takehara S, Wright FAC, Waite LM, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Seibel MJ, Handelsman DJ, Cumming RG. Oral health and cognitive status in the Concord Health and Ageing in Men Project: A cross-sectional study in community-dwelling older Australian men. Gerodontology. 2020;37(4):353-360. DOI: 10.1111/ger.12469
  71. Thillainadesan J, Scott IA, Le Couteur DG. Frailty, a multisystem ageing syndrome. Age and ageing. 2020 Aug 24;49(5):758-763. 10.1093/ageing/afaa112
  72. Thillainadesan J, Yumol MF, Hilmer S, Aitken SJ, Naganathan V. Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. Journal of the American Medical Directors Association. 2020 Dec;21(12):1833-1843.e20. 10.1016/j.jamda.2020.03.023
  73. Valdez E, Wright FAC, Naganathan V, Milledge K, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Cumming RG. Frailty and oral health: Findings from the Concord Health and Ageing in Men Project. Gerodontology. 2020;37(1):28-37. doi: 10.1111/ger.12438
  74. Wang H, Burke LJ, Patel J, Tse BW, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X. Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics. 2020;10(15):6715-27. 10.7150/thno.44900
  75. Weir KR, Naganathan V, Bonner C, McCaffery K, Rigby D, McLachlan AJ, Jansen J. Pharmacists' and older adults' perspectives on the benefits and barriers of Home Medicines Reviews - a qualitative study. Journal of health services research & policy. 2020;25(2):77-85. 10.1177/1355819619858632
  76. Wright FAC, Takehara S, Stanaway FF, Naganathan V, Blyth FM, Hirani V, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ, Cumming RG. Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project. Australasian journal on ageing. 2020;39(3): e306-e314. doi.org/10.1111/ajag.12763
  77. Le Couteur, D., Solon-Biet, S., Cogger, V., Ribeiro, R., De Cabo, R., Raubenheimer, D., Cooney, G., Simpson, S. Branched chain amino acids, aging and age-related health.Ageing Research Reviews, 2020;64, 1-11. 10.1016/j.arr.2020.101198
  78. Johnson George, Blinkhorn Anthony, Byun Roy, Foster Kirsty, Wright Fredrick A Clive. The workforce outcomes of dental graduates from a metropolitan school ‘Rural Clinical Placement Program’ versus a ‘Rural Clinical School’. International Dental Journal. 2020;70(3):214-226. 10.1111/idj.12541
  79. Teng Claris, Loy Clement T, Sellars Marcus, Pond Dimity, Latt Mark D, Waite Louise M, Sinka Victoria, Logeman Charlotte, Tong Allison. Making Decisions About Long-Term Institutional Care Placement Among People With Dementia and Their Caregivers: Systematic Review of Qualitative Studies. The Gerontologist. 2020;60(4): e329–e346. 10.1093/geront/gnz046
  80. Aitken SJ, Thillainadesan T, Monaro S, Naganathan Vasi. Collaborative models of care for older vascular surgery patients admitted to hospital. ANZ Journal of Surgery. 2020;90(7-8): 1232-1233. 10.1111/ans.16086
  81. Chen R, Irving M, Clive Wright FA, Cunich M. An evaluation of health workforce models addressing oral health in residential aged care facilities: A systematic review of the literature. Gerodontology. 2020; 37(3): 222-232. 10.1111/ger.12475
  82. Khalatbari-Soltani S, Stanaway F, Cvejic E, Blyth F, Naganathan V, Handelsman D, Le Couteur D, Seibel M, Waite L, and Cumming R. Contribution of psychosocial factors to socioeconomic inequalities in mortality among older Australian men: a population-based cohort study. International Journal for Equity in Health. 2020. 19, 177. 10.1186/s12939-020-01277-2
  83. Aitken S. J.,Lujic S.,Randall D. A.,Noguchi N.,Naganathan V.,Blyth F. M. Predicting outcomes in older patients undergoing vascular surgery using the Hospital Frailty Risk Score. British Journal of Surgery. 2020 Oct online: 10.1002/bjs.12043
  84. Cumming R, Khalatbari-Soltani S, Blyth F, Naganathan V, Le Couteur D. Not all older men have the chronic diseases associated with severe COVID-19. Australasian Journal on Ageing. 2020;39(4): 381-382. 10.1111/ajag.12839
  85. Wahl, D., Anderson, R. M., Le Couteur, D. G. Antiaging therapies, cognitive impairment, and dementia. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2020; 75(9), 1643-1652. 10.1093/gerona/glz135
  86. Wu, H., Mach, J., Le Couteur, D. G., Hilmer, S. N. Fall-related mortality trends in Australia and the United Kingdom: implications for research and practice. Maturitas. 2020;142, 68-72. 10.1016/j.maturitas.2020.07.008
  87. Wali JA, Raubenheimer D, Senior AM, Le Couteur DG, Simpson SJ. Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular research. 2021 Jan 21;117(2):386-401. 10.1093/cvr/cvaa136
  88. Weir KR, Naganathan V, Carter SM, Tam CWM, McCaffery K, Bonner C, Rigby D, McLachlan AJ, Jansen J. The role of older patients’ goals in GP decision-making about medicines: A qualitative study. BMC Family Practice 2021; 22:13 10.1186/s12875-020-01347-y
  89. Thillainadesan J, Jansen J, Close J, Hilmer S, Naganathan V. Geriatrician perspectives on perioperative care: a qualitative study. BMC Geriatrics. 2021; 68. 10.1186/s12877-021-02019-x
  90. Das A, Cumming RG, Naganathan V, Ribeiro RV, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. European journal of nutrition. 2021 Feb;60(1):443-454. 10.1007/s00394-020-02255-8
  91. Khalatbari-Soltani S, Stanaway F, Sherrington C, Blyth FM, Naganathan V, Handelsman DJ, Seibel MJ, Waite LM, Le Couteur DG, Cumming RG. The prospective association between socioeconomic status and falls among community-dwelling older men. Journal of Gerontology Medical Science. 2021;76(10):1821-1828. 10.1093/gerona/glab038
  92. Le Couteur DG, Handelsman DJ, Stanaway F, Waite LM, Blyth FM, Naganathan V, Cumming RG, Hirani V. Sarcopenic obesity and amino acids: Concord Health and Ageing in Men Project. Journal of Gerontology Biological Science 2021 May 22;76(6):1000-1004. 10.1093/gerona/glab076
  93. Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The Concord Health and Ageing in Men Project. Nutrition, Metabolism and Cardiovascular Diseases 31: 1102-1112, 2021. 10.1016/j.numecd.2020.11.032
  94. Thillainadesan Janani, Mudge Alison, Aitken Sarah, Cullen John, Yumol Minna, Close Jacqueline, Norris C, Kerdic Richard, Naganathan Vasikaran. The prognostic performance of frailty for delirium and functional decline in vascular surgery patients. Journal of the American Geriatrics Society. 2021;69(3): 688-695. 10.1111/jgs.16907
  95. Takehara S, Wright FAC, Naganathan V, Hirani V, Blyth FM, Le Couteur DG, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG. A cross-sectional study of perceived dental treatment needs and oral health status in community-dwelling older Australian men: The Concord Health and Ageing in Men Project. International Dental Journal. 2021 Jun;71(3):224-232. 10.1111/idj.12623
  96. Stanaway FF, Ribeiro RV, Khalatbari-Soltani S, Cvejic E, Blyth FM, Naganathan V, Handelsman DJ, Le Couteur DG, Simpson SJ, Waite LM, Cumming RG, Hirani V. Diet quality in an ethnically diverse population of older men in Australia. European Journal of Clinical Nutrition. 2021 Dec;75(12):1792-1800. 10.1038/s41430-021-00893-7
  97. Parkinson L, Magin P, Etherton-Beer C, Naganathan V and Mangin D. Engaging General Practice and patients with AusTAPER, a pharmacist facilitated web-based deprescribing tool. Journal of Pharmacy Practice and Research 2021: 51(2): 154-159. 10.1002/jppr.1713
  98. Hunt N, Lockwood G, Kang S, Westwood L, Limantoro C, Chrzanowski W, McCourt P, Kuncic Z, Le Couteur D, Cogger V. Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano 2021 23;15(3):4710-4727. 10.1021/acsnano.0c09278
  99. Gibney JM, Naganathan V, Lim MAWT. Oral health is Essential to the Well-Being of Older People. The American Journal of Geriatric Psychiatry. 2021 Oct;29(10):1053-1057. doi: 10.1016/j.jagp.2021.06.002. Epub 2021 Jun 11. PMID: 34246517.
  100. Thillainadesan J, Hilmer SN, Mudge AM, Aitken SJ, Kearney L, Monaro SR, Li SJ, Schasser S, Kerdic R, Tang R, Naganathan V. Understanding the role and value of process quality indicators in older vascular surgery inpatients. The Journal of Surgical Research. 2021 Jun 23;267:91-101. 10.1016/j.jss.2021.05.003
  101. Mesinovic J, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Waite LM, Handelsman DJ, Hirani V. Risk Factors for Incident Falls and Fractures in Older Men with and without Type 2 Diabetes Mellitus: The Concord Health and Ageing in Men Project, Journals Gerontology Medical Science. 2021 May 22;76(6):1090-1100. 10.1093/gerona/glab062
  102. Ng B, Duong M, Lo S, Le Couteur D, Hilmer S. Deprescribing perceptions and practice: reported by multidisciplinary hospital clinicians after, and by medical students before and after, viewing an e-learning module. Research in Social and Administrative Pharmacy 2021 17(11):1997-2005. 10.1016/j.sapharm.2021.03.002
  103. Chu KY, Cockrell D,Naganathan V, Stanaway F, Wright FAC. Oral health status of newly admitted residents living in residential aged care. Australian Dental Journal. 2021 December;66(4):391-396 10.1111/adj.12864
  104. Wu H, Mach J, Le Couteur DG, Hilmer SN. Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016. Australasian Journal on Ageing. Published online Mar 2021. 10.1111/ajag.12926
  105. Mach J, Gemikonakli G, Logan C, Vander Wyk B, Allore H, Ekambareshwar S, Kane AE, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Chronic polypharmacy with increasing Drug Burden Index (DBI) exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. The journals of gerontology Series A, Biological sciences and medical sciences. 2021 May 22;76(6):1010-1018. 10.1093/gerona/glaa060
  106. Krishnan A, Waite LM, Stanaway FF. Representation of racial and ethnic minority groups in cohort studies evaluating risk factors for dementia: protocol for a scoping review. BMJ Open. 2021 May 13;11(5):e044404. 10.1136/bmjopen-2020-044404.
  107. Wu, H, Mach J, Gemikonakli G, Tran T, Allore H, Gnjidic D, Howlett SE, de Cabo R, Le Couteur DG, Hilmer SN. Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interactions. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1748-1756. 10.1093/gerona/glab088
  108. Hew JJ , Parungao RJ, Mooney CP, Smyth JK, Kim S, Tsai KHY, Shi H, Chong C, Chan RCF, Attia B, Nicholls D, Li Z, Solon-Biet SM, Le Couteur DG, Simpson SJ, Jeschke MG, Maitz PK, Wang Y. Low-protein diet accelerates wound healing in mice post-acute injury. Burns & Trauma 2021 Aug 9;9:tkab010. 10.1093/burnst/tkab010
  109. Wali JA, Milner A, Luk A, Pulpitel T, Dodgson T, Facey H, Wahl D, Kebede M, Senior AM, Sullivan M, Brandon A, Yau B, Lockwood G, Koay YC, Ribeiro R, Solon-Biet SM1, Bell-Anderson K, O’ Sullivan J, Macia L, Forbes J, Cooney GJ, Cogger VC, Holmes A, Raubenheimer D, Le Couteur DG, Simpson SJ. Impact of dietary carbohydrate type and protein-carbohydrate interaction on metabolic health. Nature Metabolism 2021; 3:810-828. 10.1038/s42255-021-00393-9
  110. Dai Z, Hirani V, Sahni S, Felson DT, Naganathan V, Blyth F, Le Couteur D, Handelsman D, Seibel MJ, Waite L, Kiel DP, Cumming R. Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health. 2021 May 4;2601060211011798. 10.1177/02601060211011798. (Epub ahead of print)
  111. Wu H, Le Couteur DG, Hilmer SN. Mortality trends of stroke and dementia: changing landscapes and new challenges. Journal of American Geriatrics Society 2021; 69(10) 2888-2898. 10.1111/jgs.17322
  112. Hilmer SN, Mirko P, Le Couteur DG, Schwartz J, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: preliminary principles for the pandemic and beyond. British Journal of Clinical Pharmacology 2021; 87(9) 3459-3461. 10.1111/bcp.14967
  113. Milledge K, Cumming R, Wright F, Naganathan V, Blyth F, Le Couteur D, Waite L, Handelsman D, Hirani, V. Associations between the composition of Functional Tooth Units and nutrient intake in older men: The Concord Health and Ageing in Men Project. Public Health Nutrition 2021; 24(18), 6335-6345. 10.1017/S1368980021003566.
  114. Le Couteur DG, Solon-Biet SM, Parker BL, Pulpitel T, Brandon AE, Hunt NJ, Wali JA, Gokarn R, Senior AM, Cooney GJ, Raubenheimer D, Cogger VC, James DE, Simpson SJ. Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol and rapamycin. Cell Metabolism. 2021 Nov 6;S1550-4131(21)00528-3. doi: 10.1016/j.cmet.2021.10.016.
  115. Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson SJ, Hirani V. Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutrition. 2021 Oct;24(14):4490-4505. doi: 10.1017/S1368980020003547. Epub 2020 Oct 7. Erratum in: Public Health Nutr. 2021 Feb;24(2):378-383. PMID: 33023717.
  116. Khalatbari-Soltani S, Blyth FM, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Hirani V, Wright FAC, Waite LM, Cumming RG. Cohort Profile update: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology. 2021 October; 51(1):31-32h. 10.1093/ije/dyab171
  117. Khalatbari-Soltani S, Cumming R.G, Chomik R, Blyth F.M, Naganathan V, Handelsman D.J, Le Couteur D.G, Waite L.M, and Stanaway F. The association between home ownership and the health of older men: cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australasian Journal on Ageing. 2021 Sep;40(3):e199-e206. 10.1111/ajag.12896
  118. Hsu B, Korda R, Naganathan V, Lewis P, Ooi S, Brieger D, Jorm L. Burden of cardiovascular diseases in older adults using aged care services. Age and Ageing. 2021;50(5): 1845–1849. 10.1093/ageing/afab083
  119. Scott D, Blyth F, Naganathan V, Le Couteur DG, Handelsman DJ, Seibel MJ, Waite LM, Hirani V. Prospective associations of chronic and intrusive pain with sarcopenia and physical disability among older Australian men: The Concord Health and Ageing in Men Project. Experimental Gerontology 2021 Oct 1;153:111501. 10.1016/j.exger.2021.111501.
  120. Cervo M, Scott D, Seibel MJ, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Ribeiro RV, Waite LM, Hirani V. Adherence to Mediterranean Diet and its Associations with Circulating Cytokines, Musculoskeletal Health and Incident Falls in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. Clinical Nutrition 2021 Oct 23;40(12):5753-5763. 10.1016/j.clnu.2021.10.010
  121. Das A, Cumming RG, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Ribeiro RV, Simpson JS, Hirani V. Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics. 2021 (Early Online 21 Nov 10.1111/jhn.12965
  122. Fotheringham AK, Solon-Biet SM. Bielefeldt-Ohmann H, McCarthy DA, McMahon AC, Ruohonen K, Li I, Sullivan MA, Whiddett RO, Borg DJ, Cogger VC, Ballard WO, Turner N, Melvin RG, Raubenheime D, Le Couteur DG, Simpson SJ, Forbes JM. Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 2021 Oct 16;24(11):103308 10.1016/j.isci.2021.103308
  123. Smith J, Dodd RH, Hersch J, McCaffery KJ, Naganathan V, Cvejic E and Jansen J. Psychosocial and clinical predictors of continued cancer screening in older adults. Patient Education and Counseling. 2021 Dec;104(12):3093-3096. 10.1016/j.pec.2021.04.027
  124. Smith J, Dodd RH, Gainey KM, Naganathan V, Cvejic E, Jansen J and McCaffery KJ. Patient-reported factors associated with older adults’ cancer screening decision-making: A systematic review. JAMA Network Open 2021 Nov 1;4(11):e2133406. 10.1001/jamanetworkopen.2021.33406
  125. Duong, M. H., McLachlan, A. J., Bennett, A. A., Jokanovic, N., Le Couteur, D. G., Baysari, M. T., Gnjidic, D., Blyth, F., Hilmer, S. N. Iterative development of clinician guides to support deprescribing decisions and communication for older patients in hospital: a novel methodology. Drugs & Aging 2021,38, 75-87. 10.1007/s40266-020-00820-8
  126. Wahl, D., Gokarn, R., Solon-Biet, S., Cogger, V., LaRocca, T., Raubenheimer, D., Simpson, S., Le Couteur, D. (2021). Modeling nutrition and brain aging in rodents. In Martin CR, Preedy VR, Rajendram R (Eds.), Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, (pp. 517-526). London: Academic Press. 10.1016/C2018-0-02036-8
  127. Thillainadesan Janani, Yumol Minna F., Suen Michael, Hilmer Sarah, Naganathan Vasi. Enhanced Recovery After Surgery in Older Adults Undergoing Colorectal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Diseases of the Colon and Rectum. 2021;64(8):1020-1028. doi:10.1097/DCR.0000000000002128
  128. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. (November 2021) 3rd Revised Edition. Editors: Lord SR, Sherrington S and Naganathan V. Cambridge University Press. https://doi.org/10.1017/9781108594455
    Chapters
    a. Noguchi N and Naganathan V. Medical Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 172–91.
    b. Ma L and Naganathan V. Medications as Risk Factors for Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 192–201.
    c. Lord SR, Sherrington C and Naganathan V. The Relative Importance of Fall Risk Factors: Analysis and Summary. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 237–48.
    d. Latt MD and Naganathan V. The Medical Management of Older People at Risk of Falls. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 322–40.
    e. Lord SR, Sherrington C and Naganathan V. Bringing It All Together. In: Lord SR, Sherrington C, Naganathan V, editors. Falls in Older People: Risk Factors, Strategies for Prevention and Implications for Practice. 3rd ed. Cambridge: Cambridge University Press; 2021. p. 469–80.
  129. Thillainadesan J, Hilmer SN, Fleury AM, Naganathan V. New horizons in the perioperative care of older adults. Age and Ageing. 2022 Feb 2;51(2):afab245. doi: 10.1093/ageing/afab245
  130. Le Couteur DG, Anderson RM, de Cabo R. Can we make drug discovery targeting fundamental mechanisms of aging a reality? (invited editorial) Expert Opinion on Drug Discovery, 2022; 17:2, 97-100 10.1080/17460441.2022.1993818
  131. Cheyne S, Lindley R, Smallwood N, Tendal B, Chapman M, Navarro DF, Good PD, McDonald S, Morgan D, Murano M, Millard T, Naganathan V, Srikanth V, Tuffin P, Vogel J, White H, Chakrabothy SP, Whiting E, William L, Yates PM, Callary M, Elliott J and Agar MR for the National COVID-19 Clinical Evidence Taskforce. Care of older people and people requiring palliative care with COVID-19: guidance from the Australian National COVID-19 Clinical Evidence Taskforce. The Medical Journal of Australia. 2022 Mar;216(4):203-208. doi.org/10.5694/mja2.51353
  132. Wu, H., Mach, J., Gnjidic, D., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Hilmer, S. Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Ageing Research. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Mar 17. glac061, https://doi.org/10.1093/gerona/glac061 (Epub ahead of print)
  133. Xu P, Blyth F.M, Naganathan V, Cumming R.G, Handelsman D.J, Seibel M.J, Le Couteur D.G, Waite L.M, and Khalatbari-Soltani S: Socioeconomic inequalities in elective and non-elective hospitalizations in older men. JAMA Network Open. 2022 Apr 1;5(4):e226398. doi:10.1001/jamanetworkopen.2022.6398
  134. Luong, R., Ribeiro., R.V., Rangan, A., Naganathan, V., Blyth, F., Waite, L.M., Handelsman, D.J., Cumming, R.G., Le Couteur, D.G., Hirani, V. Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2022 Mar ;glac077. doi: 10.1093/gerona/glac077 (Epub ahead of print)
  135. de Cabo R, Le Couteur DG. (2022) Biology of Aging. In: Harrisons Principles of Internal Medicine (21st Ed). Editors: Loscalzo J, Fauci AS, Kasper DL, Longo DL, Jameson JL, McGraw Hill. Columbus. https://accessmedicine.mhmedical.com/content.aspx?bookid=3095§ionid=265470089
  136. Djekovic K, Clowes K, Spalding N, Waite L. A retrospective study of the behavioural and psychological symptoms of dementia in patients admitted to a Specialist Dementia Care Unit. Australasian Journal on Ageing. 2022;00:1–9. doi:10.1111/ajag.13060 (Epub ahead of print)
  137. Le Couteur DG, Flicker L, Hilmer SN. Geriatric medicine and health care for older people in Australia. Age and Ageing 2022 March; 51(3):afac001. doi.org/10.1093/ageing/afac001
  138. Thillainadesan J., Monaro S., Aitken S., Kerdic R., Cullen J., Naganathan V. Geriatric Comanagement of Older Vascular Surgery Inpatients Reduces Hospital-Acquired Geriatric Syndromes. Journal of the American Medical Directors Association. 2022 Apr;23(4):589-595.e6. doi: 10.1016/j.jamda.2021.09.037. Epub 2021 Oct 29. PMID: 34756839
  139. Shu CC, Wright FAC, Naganathan V, Blyth M, Le Couteur DG, Handelsman D.J, Stanaway FF. Does social support predict increased use of dental services in older men? Australian Dental Journal. 2022 Apr 03 https://doi.org/10.1111/adj.12911 (Epub ahead of print)
  140. Sirimanna, P., Boyce, S., Gunanayagam, P., Gladman, M.A. and Naganathan, V. Development of a rating scale for objective assessment of performance in laparoscopic appendicectomy surgery. ANZ Journal of Surgery. 2022 https://doi.org/10.1111/ans.17601 (Epub ahead of print)
  141. Ischia L., Naganathan V., Waite L.M., Le Couteur D.G., Thillainadesan J. COVID-19 and Geriatric Medicine in Australia and New Zealand. Australasian Journal on Ageing. 2022 Jun;41(2):301-308 doi.org/10.1111/ajag.13027.

Presentations:
  1. Le Couteur DG. National Geriatric Conference. Geriatric Medicine in health care of older people. Vietnam. 2021
  2. Le Couteur DG. Nathan Shock Center Birmingham University. A geometric view of nutrition and aging. USA, 2021
  3. Thillainadesan J. Age Anaesthesia Association Virtual Annual Scientific Meeting. 2 oral presentations. UK. 2021
  4. Thillainadesan J. 16th Annual Academic Surgical Congress (virtual). 2 oral presentations. USA. 2021
  5. Thillainadesan J. ANZSGM Virtual Annual Scientific Meeting. 1 oral presentation. Australia. 2021
  6. Ischia L. (supervisor Dr Thillainadesan). ANZSGM Virtual Annual Scientific Meeting. 1 oral presentation. Australia. 2021
  7. Hunt N. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 55th Annual Scientific Meeting. Nanoformulations of Insulin. Australia. 2021
  8. Hunt N. Australasian Diabetes Congress 2021. Nanomedicines formulations of metformin and nicotinamide mononucleotide dramatically improve metabolic properties in aging mice. Australia. 2021
  9. Hunt N. Liver Seminars: Young Investigators Edition, Online. Nanotechnology for cell specific drug delivery in the liver. Australia. 2021
  10. Hunt N. Sydney Nano: Meet the Author Series, Online. Targeted hepatic drug delivery using nanotechnology for metabolic and age-associated conditions. Australia. 2021
  11. Hunt N. 2021 Annual CPC EMCR Symposium. Nanotherapeutics improve metabolism in aging mice. Australia. 2021.

Research Grants

Contact details for department

Head of Department: Co-Directors: Professor Victoria Cogger and Professor Vasi Naganathan

Department/Unit: Centre for Education and Research on Ageing (CERA)
Address:
Level 4, Rusty Priest Building (Building 60)
Concord Repatriation General Hospital
Concord NSW 2139
Telephone: (02) 9767 5965
Facsimile: (02) 9767 4121
Email: Victoria.cogger@sydney.edu.au / vasi.naganathan@sydney.edu.au

 

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