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  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Andrology
Andrology
Andrology

Andrology

Our Research

The Andrology group purses basic, applied, clinical and public health research in male reproductive health, medicine and biology. Andrology is literally the study of man (Greek andros, man). The medical and scientific discipline is defined as the study of male reproductive health, medicine and biology. Male Reproductive Health involves the overlapping domains of Fertility, Sexuality and Androgenisation which overlap with male general health, especially with regard to androgen (male hormonal) effects.

The Andrology group focuses on both the biological and clinical effects of androgens on male health, in particular men's reproductive and general health across all ages. Androgens (male hormones), the main one being testosterone, occur naturally in the body and play far-reaching roles in many body systems, particularly in male reproduction, fertility and sexuality. They exert important influence on most non-reproductive tissues especially the prostate, cardiovascular system, bone and the brain, throughout the entire male lifespan and may also influence women's health.

The Andrology group is a collaboration of the:

  • Andrology Laboratory at the ANZAC Research Institute where the focus is on the physiology and pharmacology of androgens in males and females, by undertaking research using experimental animal models and laboratory bench research
  • Andrology Department of Concord Hospital, where patient and community centred research is carried out and translated into improvements in patient care.

The focus is on the therapeutic use of androgens such as to treat hormone deficiency states in adolescence and adulthood, in certain chronic diseases, for male contraception and for ageing men. In addition we also study the relatively widespread misuse/overuse and abuse of androgens for many wishful or harmful non-medical reasons as well as in sports doping.

ONGOING PROJECTS

PHYSIOLOGY & PHARMACOLOGY OF ANDROGENS:

  • Clinical Pharmacology of Testosterone AJ Conway, C Fennell, S Savkovic, L Turner, DJ Handelsman
  • Subcutaneous route of administration of androgen ester injections L Turner, C Fennell, S Savkovic, G Singh, DJ Handelsman
  • Randomised controlled trial of testosterone vs placebo to prevent diabetes (T4DM study) G Fraser, AJ Conway, V Jayadev, DJ Handelsman
  • Pharmacokinetics of testosterone via scrotal transdermal route R Iyer, SF Mok, S Savkovic, G Fraser, L Turner, DJ Handelsman
  • Randomised controlled trial of testosterone vs placebo with choice extension phase for androgen deficiency symptoms (T4DM study) SF Mok, C Fennell, G Fraser, L Turner, AJ Conway, V Jayadev, DJ Handelsman
  • Randomised controlled trial of DHT pre-treatment for poor ovarian response in IVF N Narayana-Shankara, A Marren, M Bowman, K Walters, DJ Handelsman
  • Impact and reversibility of non-prescribed androgen use on cardiac and male reproductive function S Rezapour, N Narayana-Shankara, A Conway, V Jayadev, S Savkovic, C Fennell with C Yu, C Naoum, A Ng, L Kritharides (Cardiology, Concord Hospital), L Ridley (Radiology, Concord Hospital)
  • Urine and Serum Sex Steroid and Gonadotrophin Profiles in Testosterone-Treated Transgender and Hypogonadal and Healthy Control Men S Savkovic, S Lim, L Turner, C Fennell, G Fraser, V Jayadev, AJ Conway, DJ Handelsman

LABORATORY RESEARCH:

  • Steroid Mass Spectrometry: measuring steroids in serum and biological samples R Desai, T Harwood, P Keski-Rahkonen, M Jimenez, K Walters, N Narayana-Shankara, DJ Handelsman
  • Development of urine steroid and LH assays for field studies of puberty (Archer study) G Singh, R Desai, T Sivananthan, F Bathur, DJ Handelsman with K Steinbeck (CHW)

EXPERIMENTAL STUDIES OF ANDROGEN ACTION:

  • Androgens and the Prostate U Simanainen, F Suarez, K McNamara, M Jähne, B Zhao, DJ Handelsman
  • Hormonal regulation of Sertoli cell function and spermatogenesis R Hazra, D Upton, T Rastegar, L Corcoran, J Spaliviero, M Jimenez, DJ Handelsman, CM Allan
  • Androgens and Female Reproductive Physiology K Walters, A Caldwell, D Upton, DH Lin, S Lamb, L Middleton, C Cerna, CM Allan, DJ Handelsman
  • Role of Androgens in the Breast and Uterus U Simanainen, K Walters, E Gao, P Choi, B Psarommatis, DJ Handelsman

PUBLIC HEALTH ANDROLOGY:

  • Hormonal Epidemiology of Male Ageing: The Concord Health in Ageing Men Project (CHAMP) B Hsu, R Cumming, D Le Couteur, MJ Seibel, F Blyth, V Naganathan, DJ Handelsman and others
  • Pharmacoepidemiology of testosterone prescribing and overuse LP Ly, DJ Handelsman
  • Androgen Abuse: Testosterone & Sports Doping C Fennell, M Jimenez, DJ Handelsman in collaboration with A Death, L McRobb, K McGrath (Heart Research Institute) and C Goebel, R Kazlausakas, G Trout, C Howe (National Measurement Institute)
  • Statistical methods to deduce population-based profile of androgen status in men and women over a life span K Sikaris, LP Ly, DJ Handelsman
  • Pooled Australian data on androgen status of men B Yeap,G Wittert, LP Ly, DJ Handelsman

Key Achievements

  • World leader in management of male hypogonadism

Research Staff

  • Glenda Fraser RN

Higher Degree Students:

PhD:

  • Dr Nandini Shakara Narayana
  • Dr Sivash Rezapour


Publications and Presentations

Publication Details:
  1. Jamsen KM, Bell JS, Hilmer SN, Kirkpatrick CMJ, Ilomaki J, Handelsman DJ, Le Couteur DG, Blyth FM, Naganathan V, Cumming RG, Gnjidic D. The effects of changes in number of medications and Drug Burden Index exposure on transitions between frailty states and death: the CHAMP cohort study. Journal of the American Geriatric Society 64:89-95, 2016
  2. Handelsman DJ, Sikaris K, Ly LP. Estimating age-specific trends in circulating testosterone and sex hormone binding globulin in males and females across the lifespan. Annals of Clinical Biochemistry 53:377-84, 2016
  3. Held FP, Blyth F, Gnjidic D, Hirani V, Naganathan V, Waite LM, Seibel MJ, Rollo J, Handelsman DJ, Cumming RG, Le Couteur DG. Association rules analysis of comorbidity and multimorbidity: the Concord Health and Ageing in Men Project. Journal of Gerontology A: Medical Sciences 71:625-31, 2016
  4. Noguchi N, Chan L, Cumming RG, Blyth F, Handelsman DJ, Seibel MJ, Waite L, Le Couteur DG, Naganathan V. Natural history of non-neurogenic overactive bladder and urinary incontinence over five years in community-dwelling older men: the Concord Health and Ageing in Men Project. Neurourology and Urodynamics doi: 10.1002/nau.22951, 2016
  5. Yeap BB, Knuiman MW, Divitini ML, Hui J, Arscott G, Handelsman DJ, McLennan SV, Twigg SM, McQuillan B, Hung J, Beilby JP. Epidemiological and Mendelian randomisation studies of DHT and estradiol, and leucocyte telomere length in men. Journal of Clinical Endocrinology and Metabolism 101:1299-306, 2016
  6. Wang Y, Simanainen U, Cheer K, Li D, Gao YR, Li Z, Handelsman DJ, Maitz P. Androgen actions in mouse wound healing: impact of local drug delivery. Wound Repair and Regeneration 24:478-88, 2016
  7. Boulter NR, Hendriks E, Garces Suarez FX, Schibeci SD, Sunderland TD, Tolhurst O, Hunter TA, Hodge G, Ha H, Handelsman D, Simanainen U, Duggan KA. A simple, accurate and universal method for quantification of PCR. BMC Biotechnology 16:27, 2016
  8. Hirani V, Blyth F, Naganathan V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Hsu B, Cumming RG. Low haemoglobin concentrations are associated with sarcopenia, physical performance, and disability in older Australian men in cross-sectional and longitudinal analysis: The Concord Health and Ageing in Men Project. Journal of Gerontology 71:1667-1675, 2016
  9. Hsu B, Cumming RG, Hirani V, Blyth FM, Naganathan V, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ. Longitudinal age trend in androgen status and androgen sensitive outcomes in community-dwelling older men: the Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism 101:1836-46, 2016
  10. Sinclair M, Gow PJ, Angus PW, Hoermann R, Handelsman DJ, Wittert G, Martin S, Grossmann M. High circulating estrone and low testosterone correlate with adverse clinical outcomes in men with advanced liver disease. Liver International 36:1619-1627, 2016
  11. Choi JP, Zheng Y, Handelsman DJ, Simanainen U. Glandular epithelial AR inactivation enhances PTEN inactivation-induced uterine pathology by cell specific modification of PR expression. Endocrine-Related Cancers 23:377-390, 2016
  12. Noguchi N, Cumming RG, Blyth F, Handelsman DJ, Seibel MJ, Waite L, Le Couteur DG, Naganathan V. Prevalence of the Geriatric Syndromes and Frailty in Older Men Living in the Community: the Concord Health and Ageing in Men Project. Australasian Journal of Ageing 35:255-261, 2016
  13. Hazra R, Upton D, Desai R, Noori O, Jimenez M, Handelsman DJ, Allan CM. Elevated expression of the Sertoli cell androgen receptor disrupts male fertility. American Journal of Physiology: Endocrinology and Metabolism 311:E396-404, 2016
  14. Hsu B, Hirani V, Naganathan V, Blyth FM, Le Couteur DG, Seibel MJ, Waite LM, Handelsman DJ, Cumming RG. Sexual Function and Mortality in Older Men: The Concord Health and Ageing in Men Project. Journal of Gerontology (in press)
  15. Cooper E, McGrath KCY, Li X, Akram O, Kasz R, Kazlauskas R, McLeod MD, Handelsman DJ, Heather AK. The use of tandem yeast and mammalian cell in vitro androgen bioassays to detect androgens in internet-sourced sport supplements. Drug Testing and Analysis 9(4):545-552, 2017
  16. Walters KA, Edwards MC, Jimenez M, Handelsman DJ, Allan CM. Sub-fertility in androgen insensitive female mice is rescued by transgenic FSH. Reproduction, Fertility and Development (in press)
  17. Hart RJ, Doherty DA, Keelan JA, McLachlan R, Skakkebaek NE, Norman RJ, Dickinson RE, Pennell CE, Newnham JP, Hickey M, Handelsman DJ. Early life growth predicts adult testicular function: data derived from the Western Australian (Raine) birth cohort. Journal of Clinical Endocrinology and Metabolism 101:3333-44, 2016
  18. Hsu B, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Hirani V, Waite LM, Seibel MJ, Handelsman DJ. Temporal changes in androgens and estrogens are associated with all-cause and cause-specific mortality in older men. J Clin Endocrinol Metab. 101:2201-10, 2016
  19. Chan YX, Knuiman MW, Hung J, Divitini ML, Beilby JP, Handelsman DJ, Beilin J, McQuillan B, Yeap BB. Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and non-fatal cardiovascular events, and mortality in men aged 17-97 years. Clinical Endocrinology 85:575-82, 2016
  20. Noguchi N, Chan L, Cumming RG, Blyth F, Handelsman DJ, Seibel MJ, Waite L, Le Couteur DG, Naganathan V. Lower urinary tract symptoms and incident falls in community-dwelling older men: the Concord Health and Ageing in Men Project. Journal of Urology 196:1694-1699, 2016
  21. Hsu B, Seibel MJ, Cumming RG, Blyth FM, Naganathan V, Le Couteur DG, Waite LM, Handelsman DJ. Progressive change in serum SHBG over time is associated with bone loss and incident fractures in older men: the Concord Health and Ageing in Men Project. Journal of Bone and Mineral Research 31:2115-2122, 2016
  22. Shankara-Narayana N, Zawada S, Walters KA, Desai R, Marren A, Handelsman DJ. Accuracy of a direct progesterone immunoassay. Journal of Applied Laboratory Medicine 1: 294-299, 2016
  23. Upton DH, Walters KA, Allavena R, Jimenez M, Handelsman DJ, Allan CM. Global or granulosa cell-specific Pten mutations in combination with elevated FSH levels fail to cause ovarian tumours in mice. Hormones and Cancer 7:316-326, 2016
  24. Yeap BB, Grossmann M, McLachlan RI, Handelsman DJ, Wittert GA, Conway AJ, Stuckey BG, Lording DW, Allan CA, Zajac JD, Burger HG. Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy. Med J Aust 205:173-8, 2016.
  25. Yeap BB, Grossmann M, McLachlan RI, Handelsman DJ, Wittert GA, Conway AJ, Stuckey BG, Lording DW, Allan CA, Zajac JD, Burger HG. Endocrine Society of Australia position statement on male hypogonadism (part 2): treatment and therapeutic considerations. Med J Aust 205:228-31, 2016.
  26. Jamsen KM, Gnjidic D, Hilmer SN, Ilomaki J, Le Couteur DG, Blyth FM, Handelsman DJ, Naganathan V, Waite L, Cumming RG, Bell JS. Drug Burden Index and change in cognition over time in community dwelling older men: the CHAMP study. Annals of Medicine 18:1-8, 2016
  27. Scott D, Seibel M, Cumming R, Naganathan V, Blyth F, Le Couteur DG, Handelsman DJ, Waite LM, Hirani V. Sarcopenic Obesity and its Temporal Associations with Changes in Bone Mineral Density, Incident Falls and Fractures in Older Men: The Concord Health and Ageing in Men Project. J Bone Miner Res 32:575-583, 2017 PMID: 27736026.
  28. Hirani V, Naganathan V, Blyth F, Le Couteur DG, Seibel MJ, Handelsman DJ, Waite LM, Cumming RG. Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community dwelling older men: The Concord Health and Ageing in Men Project. Age and Ageing (in press)
  29. Behre HM, Zitzmann M, Anderson RA, Handelsman DJ, Lestari S, McLachlan RI, Meriggiola MC, Misro M, Noe G, Wu FCW, Festin MPR, Habib NA, Vogelsong K, Callahan MM, Linton KA, Colvard DS. Efficacy and safety of an injectable combination hormonal contraceptive for men. Journal of Clinical Endocrinology and Metabolism 101:4779-4788, 2016
  30. Carlos Martinez C, Suissa S, Rietbrock S, Katholing A, Freedman B, Cohen AT, Handelsman DJ. Testosterone treatment and the risk of venous thromboembolism: a population-based case-control study. British Medical Journal 355:i5968 , 2016
  31. Handelsman DJ, Teede HJ, Desai R, Norman RJ, Moran LI. Evaluation of mass spectrometry steroid profiling for diagnosis of polycystic ovary syndrome. Human Reproduction 32:418-422, 2017
  32. Lam YT, Lecce L, Handelsman DJ, Ng MKC. Androgen receptor mediated genomic androgen action augments ischemia-induced neovascularization. Endocrinology 157:4853-4864, 2016.
  33. Shu CC, Cumming RG, Kendig H, Blyth FM, Waite L, Le Couteur DG, Handelsman DJ, Naganathan V. Health status, health behaviours and anxiety symptoms of older male caregivers - findings from the Concord Health and Ageing in Men Project. Australasian Journal on Ageing (in press)
  34. Held F, Le Couteur DG, Blyth FM, Hirani V, Naganathan V, Waite LM, Seibel MJ, Handelsman DJ, Cumming RG, Allore HG, Gnjidic D. Polypharmacy in older adults: Association Rule and Frequent-Set Analysis to evaluate concomitant medication use. Pharmacological Research 116:39-44, 2017
  35. Razi S, Cogger V, Handelsman DJ, Cumming RG, deCabo R, Blyth F, Naganathan V, le Couteur DG. SIRT1 polymorphisms and serum-induced SIRT1 protein expression in aging and frailty: the CHAMP study. Journal of Gerontology: Biological Sciences 72:870-876, 2017
  36. Knuuttila M, Mehmood A, Huhtaniemi R, Häkkinen M, Oksala R, Laajala TD, Rydberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Elo-Uhlgren L, Sipilä P, Mäkelä S, Poutanen M. Antiandrogens reduce intratumoral androgen concentrations and induce androgen receptor expression in castration-resistant prostate cancer xenografts. Molecular Cancer Therapeutics (in press)
  37. Chan YX, Alfonso H, Chubb SAP, Handelsman DJ, Fegan PG, Hankey GJ, GolledgeJ, Flicker L, Yeap BB. Higher dihydrotestosterone is associated with the incidence of lung cancer in older men. Hormones and Cancer 8:119-126, 2017
  38. Iyer R, Mok SF, Savkovic S, Turner L, Fraser G, Desai R, Jayadev V, Conway AJ, Handelsman DJ. Pharmacokinetics of testosterone cream applied to scrotal skin. Andrology (in press)
  39. Caldwell SL, Edwards MC, Desai R, Jimenez M, Gilchrist R, Handelsman DJ, Walters KA. Neuroendocrine androgen action is a key extra-ovarian mediator in the development of polycystic ovary syndrome. Proceedings of the National Academy of Science 114:E3334-E3343, 2017
  40. Handelsman DJ. Sex differences in athletic performance emerge coinciding with the onset of male puberty. Clinical Endocrinology (in press)
  41. McRobb LS, McGrath KCY, Tsatralis T, Liong E, Tan J, Handelsman DJ, Heather AK. Estrogen receptor downregulation is associated with transdifferentiation and mineralization of vascular smooth muscle cells in vitro and in vivo. Atherosclerosis, Thrombosis and Vascular Biology 37:1127-1137, 2017
  42. Hirani V, Blyth F, Le Couteur DG, Naganathan V, Seibel M, Handelsman DJ, Hsu B, Waite L, Cummunig RG. Longitudinal associations between vitamin D metabolites and sarcopenia in older Australian men: The Concord Health and Ageing in Men Project. Journal of Gerontology: Medical Sciences (in press)
  43. Shankara-Narayana N, Kean AM, Ohnesorg T, Ayers KL, Watson G, Vasilaris A, Sinclair A, Twigg SM, Handelsman DJ. Painful Ovulation in a 46,XX Sry-ve Adult Male with SOX9 Duplication:Case Report & Literature Review. Endocrinology, Diabetes and Metabolism Case Reports (in press)
  44. Parriera P, Maher CG, Ferriera ML, Machado GC, Handelsman DJ, Blyth FM, Naganathan V, Cumming RG. A longitudinal study of the influence of comorbidities and lifestyle factors on low back pain in older men. Pain (in press)
  45. Li R, Vannitamby A, Handelsman DJ, Hutson J. Transient neonatal hormone surge coincides with changes in early germ cell development: a model for human 'minipuberty'. Reproduction, Fertility and Development (in press)
  46. Chasland LC, Knuiman MW, Divitini ML, Chan YX, Handelsman DJ, Naylor LH, Green DJ, Yeap BB. Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men. Clinical Endocrinology (in press) 143. Walters KA, Handelsman DJ. Androgen receptor splice variants and polycystic ovarian syndrome: cause or effect? Asian Journal of Andrology 18:442-3, 2016
  47. Mok, SF, Handelsman DJ. Androgen misuse. Australian Doctor, 27-30, 12 Aug 2016.
  48. Handelsman DJ, Matsumoto AM, Gerrard D. Clinical review: doping status of DHEA treatment for female athletes with adrenal insufficiency. Clinical Journal of Sports Medicine 27:78-85, 2017
  49. Morris BJ, Kennedy SE, Wodak AD, Mindel A, Golovsky D, Schrieber L, Lumbers ER, Handelsman DJ, Ziegler JB. Early infant male circumcision: Systematic review, risk-benefit analysis, and progress in policy. World J Clin Pediatr. 6:89-102, 2017. PMID: 28224100
  50. Walters KA, Handelsman DJ. Role of androgens in the ovary. Molecular and Cellular Endocrinology
  51. Handelsman DJ. Testosterone and male ageing: faltering hope for rejuvenation. Journal of the American Medical Association (JAMA). 317:699-701, 2017
  52. Handelsman DJ. Mass spectrometry, immunoassay and valid steroid measurements in reproductive medicine and science. Human Reproduction 27:1-4, 2017.
  53. Handelsman DJ. Free testosterone: pumping up the tyres or ending the free ride? Endocrine Reviews (in press)

Book Chapters:
  1. Handelsman DJ. Chapter 24. Performance Enhancing Hormones in Sports Doping. In: DeGroot, Endocrinology, 7th Edition, Editors: Jameson L, De Groot LJ, W B Saunders, Philadelphia, 441-56, 2016 60.
  2. Handelsman DJ. Chapter 138, Androgen Physiology, Pharmacology and Abuse. In: DeGroot, Endocrinology, 7th Edition, Editors: Jameson L, De Groot LJ, W B Saunders, Philadelphia, 2368-93, 2016
  3. Handelsman DJ. Chapter 142. Male contraception. In: DeGroot, Endocrinology, 7th Edition, Editors: Jameson L, De Groot LJ, W B Saunders, Philadelphia, 2456-66, 2016
  4. Iyer R, Handelsman DJ. Testosterone misuse and abuse. In: Testosterone: From Basic to Clinical Aspects, Editor: Alexandre Hohl, Springer, 2016
  5. Iyer R, Handelsman DJ. Androgens. In: Use of Performance-Enhancing Endocrine Drugs (Doping) in Competitive and Recreational Sports Activity. Frontiers of Hormone Research Vol. 47 "Sports Endocrinology", Edditors F Lanfranco, C Strassburger. Karger, 2016
  6. Handelsman DJ. Androgen Use, Misuse and Abuse. In: Endocrinology of the Testis and Male Reproduction, editors: Simoni M, Huhtaniemi I. Springer, 2017.

Presentations:
  1. Yeap BB, Knuiman MW, Divitini ML, Hui J, Arscott GM, Handelsman DJ, McLennan SM, Twigg SM, McQuillan B, Hung J, Beilby JP. Sex hormones and biological ageing: results of epidemiological and Mendelian randomisation studies of the bioactive metabolites of testosterone, dihydrotestosterone and estradiol, and leucocyte telomere length in community-dwelling men. Proceedings of the 98th Annual Scientific Meeting, US Endocrine Society, Boston, April 2016
  2. Behre HM, Zitzmann M, Anderson RA, Handelsman DJ, Lestari S, McLachlan RI, Meriggiola MC, Misro M, Noe G, Wu FCW, Festin MPR, Habib NA, Vogelsong K, Callahan MM, Linton KA, Colvard DS. Efficacy and safety of an injectable combination hormonal contraceptive for men. Proceedings of the European Society of Contraception and Reproductive Health Congress, Basel, May 2016
  3. Hsu B, Bleicher K, Naganathan V, Blyth F, Handelsman DJ, Cumming R. Community-dwelling men with dementia are at high risk of fracture: the Concord Health and Ageing in Men Project. IOF Regionals Singapore- 6th Asia-Pacific Osteoporosis Meeting, Singapore, Nov 2016
  4. Scott D, Hirani V, Blyth F, Naganathan V, Le Couteur D, Ebeling P, Waite L, Handelsman D, Seibel M, Cumming R. Longitudinal study of sarcopenic obesity and incident falls and fractures in older men: The Concord Health And Ageing In Men Project. IOF Regionals Singapore- 6th Asia-Pacific Osteoporosis Meeting, Singapore, Nov 2016
  5. Yeap BB, Manning L, Paul Chubb SAP, Handelsman DJ, Almeida OP, Flicker L. Sex hormone concentrations and trajectories, and their associations with incident disease and physical performance in oldest old men: results from the Western Australian Health In Men Study. Proceedings of the 99th Annual Scientific Meeting, US Endocrine Society, Orlando, April 2017
  6. Hsu B, Cumming RG, Blyth FM, Naganathan V, Seibel MJ, Waite LM, Le Couteur DG, Handelsman DJ. Towards Ending the Free Ride: Evaluating the Calculated Free Testosterone as a Predictor of Adverse Health Outcomes over 5 years among Community-Dwelling Older Men: The Concord Health and Ageing in Men Project (CHAMP). Proceedings of the 99th Annual Scientific Meeting, US Endocrine Society, Orlando, USA, April 2017
  7. Le Couteur DG, Hsu B, Hirani V, Blyth F, Naganathan V, Handelsman DJ, Seibel M, Waite L, Wright FC, Cumming R. Frailty and cytokines: the CHAMP study. Proceedings of the ANZ Society of Geriatric Medicine annual scientific meeting, Rotorua, New Zealand, May 2017,
  8. Hart R, Doherty D, Keelan J, McLachlan R, Dickinson J, Newnham J, Pennell C, Norman R, Handelsman D. The impact of antenatal exposure to environmentally ubiquitous bisphenol A (BPA) on measures of male reproductive function at 20 years of age. Proceedings of the annual scientific meeting of the European Society for Human Reproduction and Embryology, Geneva, July 2017
  9. Li R, Vannitamby A, Yue S, Handelsman DJ, Hutson JM. Transient neonatal hormone urge coincides with changes in early germ cell development: a model for human 'minipuberty'. Proceedings of the Pacific Association of Pediatric Surgeons scientific meeting, Seattle, WA, USA May 2017
  10. Hart R, Frederiksen H, Doherty D, Keelan J, Skakkebaek N, Handelsman D, McLachlan R, Newnham J, Dickinson J, Pennell C, Norman R, Main K. Prenatal phthalate exposure and adult male reproductive function. 9th Copenhagen Workshop on Endocrine Disrupters (COW2017), Copenhagen, Denamrk, May 2017
  11. Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minae N, Handelsman DJ, McLachlan R, Newnham JP, Dickinson J, Pennell C, Norman RJ, Main KM. Influence of maternal phthalate exposure upon adult male reproductive function. American Society for Reproductive Medicine annual scientific meeting, October 2017, San Antonio, Texas, USA
  12. Savkovic S, Lim S, Fraser G, Fennell C, Turner L, Jayadev V, Conway A, Goebel C, Handelsman DJ. Urine and Serum Sex Steroids in Testosterone (T)-Treated Female-to-Male (F2M) Transgender and Hypogonadal Men. Proceedings of the Endocrine Society of Australia annual scientific meeting, Perth, August 2017
  13. Iyer R, Mok SF, Savkovic S, Turner L, Fraser G, Desai R, Jayadev V, Conway AJ, Handelsman DJ. Pharmacokinetics of Testosterone Administered to Scrotal Skin. Proceedings of the Endocrine Society of Australia annual scientific meeting, Perth, August 2017
  14. Lim S, Conway A, Jayadev V, Savkovic S, Fennell C, Turner L, Handelsman DJ. Clinical features of female to male (FTM) transgenders. Proceedings of the Endocrine Society of Australia annual scientific meeting, Perth, August 2017
  15. Wittert G, Atlantis E, Grossmann M, Yeap B, Conway A, Stuckey B, Handelsman D, McLachlan R, Allan C, Jenkins A, Daniel M, Bracken K on behalf of T4DM Steering Committee and Investigators. Testosterone for type 2 diabetes prevention in men with low testosterone: A 2-year multicentre, randomised, double-blind, placebo-controlled trial. Proceedings of the Endocrine Society of Australia annual scientific meeting, Perth, August 2017
  16. Shankara Narayana N, DiPierro I, Fennell C, Ly LP, Savkovic S, Turner L, Bacha F, Vrga L, Jayadev V, Conway AJ, Handelsman DJ. Sperm Cryopreservation to Insure Fertility For Men Having Gonadotoxic Treatment: Single Centre Experience over 4 Decades. Proceedings of the Endocrine Society of Australia annual scientific meeting, Perth, August 2017
  17. Rodriguez-Paris V, Edwards M, Solon-Biet SM, Bertoldo MJ, Gilchrist RB, Handelsman DJ, Walters KA. The impact of macronutrient balance on the development of polycystic ovary syndrome (PCOS) traits. Proceedings of the Society for Reproductive Biology annual scientific meeting, Perth, August 2017

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE Total ($) Years
NHMRC Teede, Norman, Hart, Handelsman, Davies,Sullivan, McNeil, Moran, Rodgers, Patton Centre for Research Excellence in the evaluation, management and health care needs of Polycystic Ovary $2,489,052 2015-2019
ARI Bridging Scheme Allan, Handelsman Testicular development and male fertility: understanding vital androgen actions $60,000 2016
NHMRC Handelsman (AI) SHOW Study (assays circulating sex steroid levels by tandem liquid chromatography mass spectrometry) $532,000 2016-2017
NHMRC Wittert, Yeap, Grossman,Conway, Allan, Kaye, Jenkins, Daniel. Testosterone intervention for the prevention of diabetes mellitus in high risk men: a randomised trial $4,800,000 2012-2016
University of Sydney/ARI Bridging Scheme Allan, Walters FSH control of follicle and oocyte development $60,000 2014-2016
ARI Bridging Scheme Walters, Smith, Handelsman, Allan Androgen receptor mediated regulation of female reproduction $60,000 2014-2016
Besins Healthcare Handelsman, Fraser, Turner, Jayedev, Conway Testosterone for Androgen Deficiency-like sympotoms (T4ADS): a three phase, placebo-controlled, double-blind Crossover study $100,000 2014-2016

Contact details for department

Head of Department: Prof DJ Handelsman

Department/Unit: Andrology
Address:
Concord Hospital
Hospital Road
Concord NSW 2139
Telephone: (02) 9767 7222
Facsimile: (02) 9767 7221
Web: www.slhd.nsw.gov.au/research/
Email: djh@anzac.edu.au