Our Research

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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Chemical Pathology

Our Research

Our section of the division of pathology is devoted to the measurement of the chemicals, hormones and metabolites that make life possible. Pathology is responsible for the study of all forms of disease, so the activities of our department are extremely broad and diverse. Our research encompasses many disorders which can be classified in terms of the organs or age-groups that they affect, but there is an understandable emphasis on those conditions that cause the greatest amount of death and disability in Australia at the moment.

Key Achievements

The departments main role is in clinical service. The provision of this service enables strong links with other departments in the Hospital and continued involvement with research and development activities as listed below.

  • FAME 1 - Eye.
  • HOPE 3 (Heart Outcomes Prevention evaluation) Define: Now observational study for patients previously treated with anacetrapib.
  • Amgen OSLER 1: A Multi-center , controlled open-label extension (OLE) study to Assess the Long term Safety and Efficacy of AMG 145.
  • Accelerate (EVACETRAPIB): Assessment of clinical effects of cholsteryl ester transfer Protein inhibition with evacetrapib in patients at a high risk for Vascular outcomes.
  • DECLARE -DAPAGLIFLOZIN: Dapagliflozin Effect on CardiovascuLAR Events A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Dapagliflozin 10 mg Once Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Ischemic Stroke in Patients with Type 2 Diabetes.

Research Staff

  • A Prof David Sullivan:- Supervisor
  • A Prof Susan McLennan:- Supervisor
  • A Prof Paul Williams:- Supervisor
  • Dr Philip Paul:- Supervisor

Higher Degree Students:

PhD:

  • Maryam Abdollahi, (PhD, Role of Neutrophil gelatinase associated Lipocalin-2 in poor wound healing in diabetes, University of Sydney) Supervisors: A/Prof S McLennan, Dr D Min.
  • Linda Ban, (PhD, Microvesicles and their role in liver disease in diabetes, University of Sydney) Supervisors: A/Prof S McLennan, A/Prof N Shackel.
  • Albert Hseish, (PhD, Studies in Graves Disease, University of Sydney). Prof S Twigg, A/Prof E Chua, Prof S Adelstein, A/Prof S McLennan, A/Prof P Williams.
  • Sergio Martinez Huenchullan, (PhD, Muscle extracellular matrix, its role in muscle function in obesity, University of Sydney) Supervisors: Prof S Twigg, Dr Charmaine Tam, A/Prof S McLennan.
  • Surya Sutanto, (PhD, Telomere length attrition in diabetes: exploring associations and cellular mechanisms, University of Sydney) Supervisors: Prof S Twigg, A/Prof S McLennan, Prof Anthony Keech.
  • Aimei Lee, (PhD, The glycoprotein Basigin in liver disease, University of Sydney) Supervisors: A/Prof N Shackel , A/Prof S McLennan, Dr T Tu.
  • Babu Maharjan,(PhD, Markers of fat cell browning, University of Sydney) Supervisors: A/Prof P Williams , A/Prof S McLennan, Prof S Twigg.

Masters:

  • Rebecca Seehoo, (Masters, Inflammation and diabetic kidney disease, University of Sydney) Supervisors: A/Prof S McLennan, Dr D Min.
  • Taria Ng, (Masters, Matrix metalloproteinases and poor wound healing in diabetes, University of Sydney)Supervisors: A/Prof S McLennan, A/Prof N Shackel.
  • Joanne Malek, (Masters, miRNA and Papillary Thyroid Cancer, University of Sydney) Supervisors: A/Prof S McLennan, A/Prof M Elliott, A/Prof E Chua.
  • Chao Wang, (Masters, Simple biometric scaffolds to improve healing in diabetic wounds, University of Sydney) Supervisors: A/Prof S McLennan, Dr Phil Boughton.
  • Luisa Olaya, (Masters, Detection of Circulating Fetal miRNA and their potential use as biomarkers of fetal anomalies) Supervisors: A/Prof J Hyett, A/Prof S McLennan.

Honours:

  • Anh Duy Tao (Hons, Matrix metalloproteinases and diabetic nephropathy), Supervisors: A/Prof S McLennan, Dr Danqing Min.
  • Brodie Hookins (Hons, miRNA and stratification of Papillary Thyroid Cancer, University of Sydney Supervisors: A/Prof S McLennan, A/Prof M Elliott, A/Prof E Chua.


Publications and Presentations

Publication Details:
  1. Chan, D., Pang, J., Barrett, P., Sullivan, D., Burnett, J., van Bockxmeer, F., Watts, G. (2016). (Omega)-3 fatty acid ethyl esters diminish postprandial lipemia in familial hypercholesterolemia. Journal of Clinical Endocrinology and Metabolism, 101(10), 3732-3739.
  2. Anastasius, M., Kockx, M., Jessup, W., Sullivan, D., Rye, K., Kritharides, L. (2016). Cholesterol efflux capacity: An introduction for clinicians. American Heart Journal, 180, 54-63.
  3. Cho, L., Rocco, M., Colquhoun, D., Sullivan, D., Rosenson, R., Dent, R., Xue, A., Scott, R., Wasserman, S., Stroes, E. (2016). Clinical Profile of Statin Intolerance in the Phase 3 GAUSS-2 Study. Cardiovascular Drugs and Therapy, 30(3), 297-304. 
  4. Chan, D., Pang, J., Barrett, P., Sullivan, D., Mori, T., Burnett, J., van Bockxmeer, F., Watts, G. (2016). Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy. Nutrition, Metabolism & Cardiovascular Diseases, 26(12), 1140-1145. 
  5. Hague, W., Simes, R., Kirby, A., Keech, A., White, H., Hunt, D., Nestel, P., Colquhoun, D., Pater, H., Stewart, R., Sullivan, D., et al (2016). Long-Term Effectiveness and Safety of Pravastatin in Patients With Coronary Heart Disease: Sixteen Years of Follow-Up of the LIPID Study. Circulation, 133(19), 1851-1860. 
  6. Williams, K., Sullivan, D., Veillard, A., O'Brien, R., George, J., Jenkins, A., Young, S., Ehnholm, C., Duffield, A., Twigg, S., Keech, A. (2016). Low alanine aminotransferase levels and higher number of cardiovascular events in people with Type 2 diabetes: analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetic Medicine, 33(3), 356-364. 
  7. Williams, K., Sullivan, D., Nicholson, G., George, J., Jenkins, A., Januszewski, A., Gebski, V., Manning, P., Tan, Y., Donoghoe, M., Buizen, L., Twigg, S., Keech, A., et al (2016). Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes: Analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Metabolism: Clinical and Experimental, 65(5), 783-793.
  8. Alshehry, Z., Mundra, P., Barlow, C., Mellett, N., Wong, G., McConville, M., Simes, R., Tonkin, A., Sullivan, D., Barnes, E., Neal, B., et al (2016). Plasma lipidomic profiles improve upon traditional risk factors for the prediction of cardiovascular events in Type 2 diabetes. Circulation, 134(21), 1637-1650.
  9. Lee, A., Rode, A., Nicoll, A., Maczurek, A., Lim, L., Lim, S., Angus, P., Kronborg, I., Arachchi, N., Gorelik, A., Warner, F., McCaughan, G., McLennan, S., Shackel, N., et al (2016). Circulating CD147 predicts mortality in advanced hepatocellular carcinoma. Journal of Gastroenterology and Hepatology, 31(2), 459-466. 
  10. Yeap, B., Knuiman, M., Divitini, M., Hui, J., Arscott, G., Handelsman, D., McLennan, S., Twigg, S., McQuillan, B., Hung, J., et al (2016). Epidemiological and mendelian randomization studies of dihydrotestosterone and estradiol and leukocyte telomere length in men. Journal of Clinical Endocrinology and Metabolism, 101(3), 1299-1306. 
  11. Ban, L., Shackel, N., McLennan, S. (2016). Extracellular vesicles: A new frontier in biomarker discovery for non-alcoholic fatty liver disease. International Journal of Molecular Sciences, 17(3), 1-14. 
  12. Min, D., Brooks, B., Wong, J., Aamidor, S., Seehoo, R., Sutanto, S., Harrisberg, B., Yue, D., Twigg, S., McLennan, S. (2016). Monocyte CD163 is altered in association with diabetic complications: possible protective role. Journal of Leukocyte Biology, 100(6), 1375-1383. 
  13. Januszewski, A., Sutanto, S., McLennan, S., O'Neal, D., Keech, A., Twigg, S., Jenkins, A. (2016). Shorter telomeres in adults with Type 1 diabetes correlate with diabetes duration, but only weakly with vascular function and risk factors. Diabetes Research and Clinical Practice, 117, 4-11.
  14. Park, F., Russo, K., Williams, P., Pelosi, M., Puddephatt, R., Walter, M., Leung, B., Saaid, R., Rawashdeh, H., Ogle, R., Hyett, J. (2016). Prediction and Prevention of Early-Onset Preeclampsia: Impact of Aspirin after First-Trimester Screening. Obstetrical and Gynecological Survey, 71(1), 11-13. 
  15. Maia e Holanda Moura, S., Park, F., Murthi, P., Martins, W., Kane, S., Williams, P., Hyett, J., Da Silva Costa, F. (2016). TNF-R1 as a first trimester marker for prediction of pre-eclampsia. The Journal of Maternal-Fetal & Neonatal Medicine, 29(6), 897-903.
     

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE Total $$ Years
NH&MRC APP1063515 N Shackel, SV McLennan, G McCaughen The Role of the Hepatocyte and EMMPRIN in Liver Injury  $587,562 2014-16

Contact details for department

Head of Department: A/Professor David Sullivan

Department/Unit: Chemical Pathology
Address:
RPA Hospital
Missenden Road
Camperdown NSW 2050
Telephone: (02) 9515 5246
Facsimile: (02) 9515 6186
Web: www.slhd.nsw.gov.au/research/
Email: stella.vlahos@health.nsw.gov.au