Academic Colorectal Unit
The key themes of pioneering research within the Academic Colorectal Unit are:
- Health Services: state-wide, population-based studies to explore variation in outcomes following major colorectal surgery;
- Clinical Science: advanced, state-of-the-art physiological measurement of gastrointestinal function to accurately define phenotypic variation in pelvic floor and functional gastrointestinal disorders;
- Translational Basic Science: enteric neuroscience research to determine the molecular, electrophysiological and neuropathophysiological basis of gastrointestinal conditions.
Each year more than 230 million major operations are performed worldwide, one for every 25 people in the world. Diseases of the bowel are among the commonest in the population, with bowel cancer being the second most common type of newly diagnosed cancer in Australia and the second biggest cancer killer.
Furthermore, bowel problems such as constipation and incontinence are one of the most frequent reasons why people visit doctors, with approximately 1 in 10 people suffering with each of these problems. Despite these staggering statistics, very little is known about how the bowel works in healthy individuals and what goes wrong in diseases and disorders such as cancer and constipation.
More importantly, it is unclear how many operations are performed for bowel problems in Australia each year and what results are achieved following surgery.
The research Group focuses on clinical, epidemiological and translational research into diseases and disorders of the gastrointestinal tract. There are established International collaborations with: Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Sweden Center for Health Outcomes & Policy, University of Michigan, USA.
Recently, we have been able to successfully perform electrophysiological recordings from the nerves supplying the bowel in humans, which has enabled us to 'listen in' to the messages passing along nerves to the muscles that control the bowel. We have also mapped different classes of neurons and perform neurochemical coding to better identify different groups among the many hundreds of thousands of nerves that are contained within the bowel using special techniques.
- Professor Marc Gladman, Director
- A/Prof Natasha Nassar, Visiting Principle Research Fellow
- Dr David Mahns, Visiting Senior Lecturer
- Dr Michael Suen, Senior Lecturer
Publications and Presentations
- Ng KS, Brookes SJ, Montes-Adrian NA, Mahns DA, Gladman MA. Electrophysiological characterisation of human rectal afferents. Am J Physio - Gastro Liver 2016; 311: G1047-G1055.
- Boyce S, Nassar N, Alzahrani S, Suen M, Lee Y, Gladman MA. Young-onset colorectal cancer in New South Wales, Australia: a population-based study. MJA 2016; 205: 465-470.
- Ng KS, Stewart P, Gladman MA. Post-operative lower GI haemorrhage following bowel resection. ANZ J Surg 2016 Oct; 86: 836-837.
- Mirbagheri N, Sivakumaran Y, Nassar N, Gladman MA. Systematic Review of the Impact of Sacral Neuromodulation on Clinical Symptoms and Gastrointestinal Physiology. ANZ J Surg 2016; 86: 232-6.
- Whiteley I, Russell M, Nassar N, Gladman MA. Outcomes of Support Rod Usage in Loop Stoma Formation. Int J Colorectal Dis 2016; 31: 1189-95.
- Mirbagheri N, Dunn G, Naganathan V, Suen M & Gladman MA. 'Normal Values and Clinical Utility of Bedside Sonographic Assessment of Postoperative Gastric Emptying: A Prospective Cohort Study'. Dis Colon Rectum 2016; 59: 758-765.
- A 3D-SPECT Study of Colonic Transit following Hindgut Surgery: A Novel Clue to Anterior Resection Syndrome. Ng KS, Russo R, Gladman MA. The Association of Coloproctology of Great Britain and Ireland, Edinburgh, UK, July 2016.
- Outcomes following Emergency Colorectal Surgery in NSW, Australia: A Population-Based Health Data Linkage Study. Ng KS, Nassar N, Gladman MA. The Association of Coloproctology of Great Britain and Ireland, Edinburgh, UK, July 2016.
- Quantitative Characterisation & Neurochemical Coding of the Human Hindgut Myenteric Plexus. Ng KS, Mahns DA, Gladman MA. The Association of Coloproctology of Great Britain and Ireland, Edinburgh, UK, July 2016.
- Faecal Incontinence: Knowledge, Skills and Barriers to Specialist Referral amongst Australian Primary Healthcare Providers. Soares DS, Koneru S, Ng KS, Gladman MA. International Continence Society meeting, Tokyo, Japan September 2016.
- Feasibility and Clinical Utility of Bedside Sonographic Assessment of Postoperative Gastric Emptying: A Pilot Study'. Mirbagheri N, Dunn G, Suen M, Naganathan V & Gladman MA. Royal Australasian College of Surgeons Annual Scientific Congress, Brisbane, May 2016.
- Impact of Interrupting Sacral Neuromodulation on Anorectal Physiology in Patient with Faecal Incontinence: A Randomized, Double-blinded Cross-over Study. Mirbagheri N, Whiteley I, Chan KY & Gladman MA. Royal Australasian College of Surgeons Annual Scientific Congress, Brisbane, May 2016.
- Central Brain Responses Following Sacral Neuromodulation in Patients with Faecal Incontinence. Mirbagheri N, Hatton S, Lagopoulos & Gladman MA. Royal Australasian College of Surgeons Annual Scientific Congress, Brisbane, May 2016.
- Faecal Incontinence: Knowledge, Skills and Barriers to Specialist Referral Amongst Australian Primary Healthcare Providers. Soares DS, Koneru S, Ng KS, Gladman MA. Surgical Research Society Meeting, Melbourne, November 2016.
- Anterior Resection Syndrome - Does Time Heal all Wounds? Wright DB, Ng KS, Gladman MA. Surgical Research Society Meeting, Melbourne, November 2016.
- Anterior Resection Syndrome - Should We Be Telling Our Patients to Expect More? Wright DB, Ng KS, Gladman MA. Surgical Research Society Meeting, Melbourne, November 2016.
Contact details for department
Head of Department: Professor Marc Gladman
Department/Unit: Academic Colorectal Unit
Telephone: (02) 9767 6928
Facsimile: (02) 9515 9610