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  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Drug Health Services

Our Research

Research Summary Research within Drug Health Services (DHS) adopts a multi-disciplinary approach and encompasses a broad range of disciplines including clinical toxicology, addiction medicine, public health, epidemiology, hepatology, mental health and Aboriginal health. There are direct links to the University of Sydney (USYD) including the School of Pharmacology and long standing affiliations with the National Drug and Alcohol Research Centre (NDARC), AW Morrow Gastroenterology and Liver Centre (AWM) and the Centenary Institute of Cancer Medicine and Cell Biology (CI).

Addiction Medicine provides a multidisciplinary approach to address Alcohol, tobacco and illicit substance use and related harm. The DHS team has conducted a number of randomized controlled trials to test new treatments for alcohol and related disorders. Clinical service evaluations have been undertaken of both internal components of the clinical drug health service of SLHD and external agencies.

Public Health research focuses on patterns of use, and prevention, treatment and harm reduction approaches. This includes approaches to prevent and treat harms associated with drug and alcohol use, such as blood-borne virus infection, including needle and syringe programs, primary health care, a variety of treatment programs such as opioid substitution treatment, and specific women's and children's health and social issues.

Aboriginal Health research (led by Professor Kate Conigrave) is involved in developing culturally appropriate, accessible and innovative approaches to prevent alcohol or other drug use disorders. A key feature of this work is strong partnerships with local Aboriginal communities and services. Our work with partners in regional NSW and in remote NT, and at the University of Sydney, has been recognised by state and national awards. A new NHMRC Centre of Research Excellence has been awarded in 2016 to this team to train indigenous researchers to identify solutions to alcohol problems. We also work to translate research into knowledge that is accessible to Aboriginal health professionals and Aboriginal community, and resources we have developed are in use around the country.

Biomedical and Genetic Research in liver disease (led by Associate Professor Devanshi Seth), is an important area of research at DHS. Our clinical and basic research in liver disease aims to understand the mechanisms of how alcohol injures the liver and identify potential genetic and non-genetic bio-markers as therapeutic and/or diagnostic agents. The team is currently investigating the mechanisms of action of novel molecules and pathways in the development of liver cirrhosis and compensatory liver regeneration in patients and in animal/cell culture models of alcohol. The international GenomALC Consortium has established the largest biobank of drinkers, linked to clinically well characterised database. The bio-specimens will be genotyped to identify gene mutations that predispose some drinkers to cirrhosis and protect others from liver injury.

Clinical Research in Alcohol Treatment and associated mental health is a major area of interest with ongoing randomised control trials, including comorbid substance abuse and suicide risk. The team (led by Prof Paul Haber) is leading world first research into alcohol dependence, alcoholic liver disease and their associated psychological comorbidities under the NHMRC Centre of Research Excellence in Mental Health and Substance Use.

Clinical Toxicology's scope includes acute and chronic medicine and chemical poisoning, serious adverse prescribed and non-prescribed drug reactions and toxicology that create a substantial source of morbidity and mortality across the world. The team (led by Professors Andrew Dawson and Nick Buckley) has established the largest prospective cohort of acute poisoning in the world, The Australian National Poisons Registry and developed treatment guidelines resulting in policy and regulatory changes. Much of their national research is based on detecting early signals of significant drug toxicity and measuring the public health impact of regulatory change.

Translational Research projects, lead by Prof Haber, Prof Conigrave and Dr Morley aim to increase uptake of evidence-based treatment. These projects are funded by NHMRC and NSW Health and include: increasing uptake of evidence-based treatment for alcohol problems in the indigenous community, improving the management of comorbid mental health and substance use with an integrated approach (including a multi-modal training package to several sites across NSW Health LHD's) and a shared care pathway for the treatment of alcohol use disorders in primary care. A/Prof Carolyn Day and Ms Louise Ross also conducted work into evidence-based interventions for tobacco cessation.

Medical Education is a key focus of the Research Unit, which provides opportunities for medical, public health, science, nursing and psychology graduates (Honours, Masters, MPhil and PhD) and contributes to teaching in a range of course at the University of Sydney, including Masters of Public Health, Master of Health Policy, and Graduate Diploma in Indigenous Health Promotion. The Research Unit at DHS is engaged in the placement of overseas trainees/students, teaching/training of GPs and Aboriginal drug and alcohol workers and other clinicians across Australia. Toxicology is delivering a Masters Clinical Toxicology distance learning course and developed and Opensource curriculum.

Opportunities exist to undertake post graduate studies in the areas outlined above, from a basic science, clinical or public health perspective.

Key Achievements

  • Prof Kate Conigrave was appointed as chair of NHMRC Alcohol Working Committee. This committee is responsible for reviewing the Australian drinking guidelines.
  • Prof Kate Conigrave is lead investigator of a team awarded an NHMRC Centre for Research Excellence (CRE): Building Indigenous research capacity to find solutions to alcohol problems' ($2.4m). This CRE was chosen by the NHMRC as its lead story for funding awarded, and Hon Sussan Ley MP, Ken Wyatt MP, and the head of NHMRC (Ann Kelso) attended Sydney to announce its award. It will commence in May 2017.
  • Prof Kate Conigrave was awarded an NHMRC Practitioner Fellowship, 'Working with Indigenous services and communities to reduce the harms from alcohol'. This fellowship, which commences in January 2017, will allow Prof Conigrave to further her work in this field.
  • Prof Nick Buckley appointed Fellow of the American College of Medical Toxicology.
  • Prof Nick Buckley appointed to the NSW Health Medication Safety Expert Advisory Committee.
  • Prof Andrew Dawson appointed Scientific Chair Asia Pacific Association Medical Toxicology. This is the peak regional scientific body for Clinical Toxicologists.
  • Professor Andrew Dawson appointed to Environmental Health Expert Advisory Panel (EHEAP), NSW Environmental Protection.
  • Prof Paul Haber and Dr Kirsten Morley completed one of the largest trials of baclofen in the treatment of alcohol use disorders in the world.
  • Prof Haber and Dr Kirsten Morley awarded Translational Research Grant in the inaugural round by NSW Health. This grant was awarded to implement the Stepped Care model for substance use mental health comorbidity in NSW drug and alcohol treatment services. It will be undertaken at six clinical sites across four LHDs and if successful, will be rolled out state-wide.
  • Dr Kirsten Morley awarded NHMRC TRIP Fellowship ($177,000) 'A shared care pathway for the treatment of alcohol use disorders'.
  • Dr Kirsten Morley awarded NSW Health Translational Research Fellowship ($358,000) 'Improving management of comorbid mental health and substance use with an integrated approach'.
  • The GenomALC study under the leadership of Devanshi Seth and Tim Morgan (USA) achieved key milestones during 2016. The first phase of prospective recruitment for GenomALC study completed in 2016. More than 20 international sites across Australia, France, Germany, Switzerland, United Kingdom and United States, finished enrolment. Overall recruitment was 133% (n=6670), more than initial target (n=5000), with prospective enrolment achieving ~84% of the target (n=2088 of 2500) and Sydney contributing 18% of prospective collection.
  • TheGenomALC study signed contract with Erasmus University Medical Centre, Netherlands for performing genotyping. A major and significant advancement was contracting Erasmus University Medical Centre Rotterdam, Netherlands to perform genotyping on our 6670 specimens in 2017. This contract is the most cost-effective deal, saving the study and funding agency (NIAAA) ~US$750,000, in addition to maintaining the integrity of genotyping performed in a timely manner. GenomALC study leaders Seth and Morgan convinced NIH-NIAAA leadership to approve this variation from original protocol.
  • Approval to access the mega-cohort genomic database UK Biobank. Two mega-cohort genomic databases, UK Biobank (500K) and US Million Veteran Program (I million) were identified as validation cohorts for SNPs identified in GenomALC discovery phase. MVP database access is under consideration. The UK Biobank access application, led by Devanshi Seth, was approved. This is a most significant development enabling GenomALC study to confirm SNPs discovery in a large replication sample.
  • International collaborative project Australia India Strategic Research Fund (AISRF) led by Assoc Prof Devanshi Seth (Australia) and Prof Shiv Sarin (Institute of Liver & Biliary Sciences, India): Study completion and presentation at international meeting. This international study completed successfully and resulted in joint presentation at the international meeting European Association for the Study of the Liver (EASL), 2016.

Awards/Medals

  • Prof Nick Buckley and colleagues (Schaffer A, Dobbins T, Banks E, Pearson SA), winners of the MJA / MDA National Research Award for the best research article published in the MJA in 2015 'The crux of the matter: Did the ABC's Catalyst program change statin use in Australia?'
  • Dr Kylie Lee was a finalist (top 4) nomination for Best Docudrama at the Australian Teachers of Media (ATOM) Award for ' Kasippu (alcohol)' a film made in rural Sri Lanka (with University of Peradeniya, South Asian Clinical Toxicology Research Collaboration, Drug Health's Clinical Toxicology Unit, University of Sydney and The Perfect World).
  • Dr Kylie Lee received Merit Award at the International Film Festival for Family, Against Drugs Abuse and Trafficking (Indonesia) for 'Kasippu (alcohol)' a film made in rural Sri Lanka (with University of Peradeniya, South Asian Clinical Toxicology Research Collaboration, Drug Health's Clinical Toxicology Unit, University of Sydney and The Perfect World).

Research Staff

Professors:

  • Associate Professor Andrew Baillie, Honorary Clinical Psychologist
  • Professor Nicholas Buckley, Clinical Academic
  • Professor Kate Conigrave, Senior Staff Specialist
  • Associate Professor Carolyn Day, Drug and Alcohol Coordinator, Sydney Medical School
  • Professor Andrew Dawson, Senior Staff Specialist
  • Professor Paul Haber, Clinical Director
  • Associate Professor Darren Roberts, Staff Specialist
  • Associate Professor Devanshi Seth, Principal Scientist

Academic staff:

  • Dr Jonathan Brett, Staff Specialist
  • Dr Kenneth Curry, Senior Staff Specialist
  • Dr Richard Hallinan, Staff Specialist
  • Dr Cathy Heyes, Clinician
  • Dr Kylie Lee, Senior Lecturer
  • Dr Kirsten Morley, Senior Research Fellow
  • Dr Bridin Murnion, Senior Staff Specialist
  • Dr Sharon Reid, Career Medical Officer
  • Dr Bethany White, Postdoctoral Research Associate

Researchers:

  • Ms Ainsley Forneaux-Bate, Research Assistant
  • Ms Isabel Fraser, Research Assistant
  • Ms Pip Hotham, Research Assistant
  • Ms Jessica Hyman, Research Assistant
  • Ms Eva Louie, Research Assistant
  • Ms Khairunnessa Rahman, Research Assistant
  • Ms Louise Ross, Counsellor
  • Ms Ann White, Clinical Nurse Consultant

Higher Degree Students:

PhD:

  • Mr  Mustafa Al Ansari
  • Ms Basma Al Ansari
  • Dr Jonathan Brett
  • Ms Kerryn Butler
  • Ms Angela Chiew
  • Mr Ben Daniels
  • Mr Kevin Liou
  • Mr Warren Lodge
  • Mr Van Long
  • Ms Eva Louie
  • Ms Sandi Mitchell
  • Mr Colin Page
  • Mr Tim Pianta
  • Mr Smriti Raichand
  • Dr Sharon Reid
  • Ms Andrea Schaffer
  • Thilini Wijerathne

Masters:

  • Mr Lionel Danko-Swarte
  • Ms Lakmini DeSilva
  • Dr Alon Faingold
  • Ms Pip Hotham
  • Ms Vindya Pathirana
  • Mr Janaka Pushpakumara


Publications and Presentations

Publication Details:
  1. Al-Ansari, B., Day, C., Thow, A., Conigrave, K. (2016). Civil alcohol policy in Muslim majority countries: need for global tools, expert support and local partnerships. Addiction, 111(10), 1718-1719.
  2. Al-Ansari, B., Thow, A., Day, C., Conigrave, K. (2016). Extent of alcohol prohibition in civil policy in Muslim majority countries: the impact of globalization. Addiction, 111(10), 1703-1713.
  3. Anstee, Q., Seth, D., Day, C. (2016). Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease. Gastroenterology, 150(8), 1728-1744.
  4. Berling, I., Buckley, N., Isbister, G. (2016). The antipsychotic story: changes in prescriptions and overdose without better safety. British Journal of Clinical Pharmacology, 82(1), 249-254.
  5. Black, K., Day, C. (2016). Improving Access to Long-Acting Contraceptive Methods and Reducing Unplanned Pregnancy Among Women with Substance Use Disorders. Substance Abuse: Research and Treatment, 10(Suppl. 1), 27-33.
  6. Breen C, Burns L, Day CA. (2016). Alcohol use among reproductive aged women: The role of the clinical psychologist. Australian Clinical Psychologist, 2:1.
  7. Brett, J., Lee, K., Gray, D., Wilson, S., Freeburn, B., Harrison, K., Conigrave, K. (2016). Mind the gap: What is the difference between alcohol treatment need and access for Aboriginal and Torres Strait Islander Australians? Drug and Alcohol Review, 35(4), 456-460.
  8. Buckley NA, Dawson AH, Juurlink D, Isbister GK (2016). Who gets antidotes? Choosing for the chosen few. British Journal of Clinical Pharmacology, 81(3):402-7.
  9. Buckley, N., Dawson, A., Isbister, G. (2016). Treatments for paracetamol poisoning. British Medical Journal, 353:i2579
  10. Buckley, N., Dawson, A., Isbister, G. (2016). Authors' reply to Thomas and colleagues 'Guidance on acetylcysteine for paracetamol ingestion needs review'. British Medical Journal, 2016;353:i3461
  11. Cairns R, Brown J, Buckley NA (2016). Dangerous toys: the expanding problem of water-absorbing beads Medical Journal of Australia, 205(11): 528.
  12. Cairns, R., Brown, J., Lynch, A., Robinson, J., Wylie, C., Buckley, N. (2016). A decade of Australian methotrexate dosing errors. Medical Journal of Australia, 204(10), 384.
  13. Cairns R, Brown J, Buckley NA (2016). Author's response to correspondence re 'A decade of Australian methotrexate dosing errors'. Medical Journal of Australia, 205(10):486.
  14. Cairns, R., Brown, J., Buckley, N. (2016). The impact of codeine re-scheduling on misuse: a retrospective review of calls to Australia's largest poisons centre. Addiction, 111(10), 1848-1853.
  15. Chan B, Buckley NA. A decade of Australian methotrexate dosing errors (2016). Letter, Medical Journal of Australia, 205(10):485.
  16. Chan, B., Isbister, G., O'Leary, M., Chiew, A., Buckley, N. (2016). Efficacy and effectiveness of anti-digoxin antibodies in chronic digoxin poisonings from the DORA study (ATOM-1). Clinical Toxicology, 54(6), 488-494.
  17. Chiew A, Isbister GK, Duffull S, Buckley NA (2016). Evidence for changing use of acetylcysteine. British Journal of Clinical Pharmacology, 81(3):471-81.
  18. Chitty, K., Osborne, N., Cairns, R., Dawson, A., Buckley, N. (2016). Trends in recreational poisoning in Newcastle, Australia, between 1996 and 2013. Drug and Alcohol Dependence, 159, 17-25.
  19. Connor, J., Haber, P., Hall, W. (2016). Alcohol use disorders. The Lancet, 387(10022), 988-998.
  20. Dawson AH, Buckley NA (2016). Pharmacological management of anti-cholinergic delirium - theory, evidence and practice. British Journal of Clinical Pharmacology, 81(3):516-24.
  21. Dawson, A., Buckley, N. (2016). Digoxin. Medicine (United Kingdom), 44(3), 158-159.
  22. Day, C., Shanahan, M., Wand, H., Topp, L., Haber, P., Rodgers, C., Deacon, R., Walsh, N., Kaldor, J., Van Beek, I., et al (2016). Development of immunity following financial incentives for hepatitis B vaccination among people who inject drugs: A randomized controlled trial, Journal of Clinical Virology, 74, 66-72.
  23. Day, C., White, B., Haber, P. (2016). The impact of an automatic syringe dispensing machine in inner-city Sydney, Australia: No evidence of a 'honey-pot' effect. Drug and Alcohol Review, 35(5), 637-643
  24. Ediriweera, D., Kasturiratne, A., Pathmeswaran, A., Gunawardena, N., Wijayawickrama, B., Jayamanne, S., Isbister, G., Dawson, A., Giorgi, E., Diggle, P., et al (2016). Mapping the risk of snakebite in Sri Lanka - a national survey with geospatial Analysis. PLoS Neglected Tropical Diseases, 10(7), 1-14.
  25. Freyer, C., Morley, K., Haber, P. (2016). Alcohol use disorders in Australia. Internal Medicine Journal, 46(11), 1259-1268.
  26. Grebely, J., Alavi, M., Micallef, M., Dunlop, A., Balcomb, A., Phung, N., Weltman, M., Day, C., Treloar, C., Bath, N., Haber, P., et al (2016). Treatment for hepatitis C virus infection among people who inject drugs attending opioid substitution treatment and community health clinics: The ETHOS Study. Addiction, 111(2), 311-319.
  27. Haber, P., Morley, K. (2016). The impact of alcohol pharmacotherapies on public health in Australia is limited by low prescribing rates. Public Health Research and Practice, 26(4), 1-4.
  28. Heyes, C., Baillie, A., Schofield, T., Gribble, R., Haber, P. (2016). The Reluctance of Liver Transplant Participants with Alcoholic Liver Disease to Participate in Treatment for Their Alcohol Use Disorder: An Issue of Treatment Matching? Alcoholism Treatment Quarterly, 34(2), 233-251.
  29. Heyes, C., Schofield, T., Gribble, R., Day, C., Haber, P. (2016). Reluctance to Accept Alcohol Treatment by Alcoholic Liver Disease Transplant Patients: A Qualitative Study. Transplantation Direct, 2(10), 1-9.
  30. Hulse, E., Shihana, F., Buckley, N. (2016). Methemoglobin measurements are underestimated by the Radical 7 co-oximeter: experience from a series of moderate to severe propanil poisonings. Clinical Toxicology, 54(9), 826-828.
  31. Isbister GK, Buckley NA (2016). Good Clinical Guidelines must define the setting, patients and evidence: Benzodiazepines vs Droperidol for Acute Behavioural Disturbance in the Emergency Department. Australian NZ J Psychiatry, 50(12):1200-1202
  32. Isbister, G., Buckley, N. (2016). Therapeutics in clinical toxicology: In the absence of strong evidence how do we choose between antidotes, supportive care and masterful inactivity. British Journal of Clinical Pharmacology, 81(3), 408-411.
  33. Karanges, E., Blanch, B., Buckley, N., Pearson, S. (2016). Twenty-five years of prescription opioid use in Australia: a whole-of-population analysis using pharmaceutical claims. British Journal of Clinical Pharmacology, 82(1), 255-267.
  34. Lamb, T., Selvarajah, L., Mohamed, F., Jayamanne, S., Gawarammana, I., Mostafa, A., Buckley, N., Roberts, M., Eddleston, M. (2016). High lethality and minimal variation after acute self-poisoning with carbamate insecticides in Sri Lanka - implications for global suicide prevention. Clinical Toxicology, 54(8), 624-631.
  35. Lee, K, Dawson, A., & Conigrave, K. (2016). Insights into the effective management of support groups for Aboriginal Australian women with substance use disorders. Society, Health and Vulnerability http://dx.doi.org/10.3402/shv.v7.29474.
  36. Lee, K, Freeburn, B., Ella, S., Wilson, S., Harrison, K., McEWan, M., & Conigrave, K. (2016). Supporting the Aboriginal alcohol and other drug workforce in New South Wales, Australia. Drug and Alcohol Review (accepted 11 July 2016).
  37. Liangpunsakul S, Haber P, McCaughan G (2016). Alcoholic Liver Disease in Asia, Europe, and North America. Gastroenterology, Jun;150(8):1786-97
  38. Liou, K., Jepson, N., Buckley, N., Chen, V., Thomas, S., Russell, E., Ooi, S. (2016). Design and Rationale for the Endothelin-1 Receptor Antagonism in the Prevention of Microvascular Injury in Patients with non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention (ENDORA-PCI) Trial. Cardiovascular Drugs and Therapy, 30(2), 169-175.
  39. Martinello, M., Hellard, M., Shaw, D., Petoumenos, K., Applegate, T., Grebely, J., Yeung, B., Maire, L., Iser, D., Haber, P., et al (2016). Short duration response-guided treatment is effective for most individuals with recent hepatitis C infection: The ATAHC II and DARE-C i studies. Antiviral Therapy, 21(5), 425-434.
  40. Mina MM, Cameron B, Luciani F, Vollmer-Conna U, Lloyd AR HITS-P investigators (2016). Natural killer cells in highly exposed hepatitis C-seronegative injecting drug users. J Viral Hepat, Jun;23(6):464-72
  41. Mitchell S, Bungay V, Day CA, Mooney-Somers J. (2016). Will the moment of Hepatitis C diagnosis undermine the promise of new treatments? An analysis of Canadian women's experiences. Canadian Journal of Nursing Research, 48(1); 21-28.
  42. Mohamed, F., Endre, Z., Pickering, J., Jayamanne, S., Palangasinghe, C., Shahmy, S., Chathuranga, U., Wijerathna, T., Shihana, F., Buckley, N., et al (2016). Mechanism-specific injury biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning. Toxicology Letters, 258, 1-10.
  43. Morley, K., Baillie, A., Leung, S., Sannibale, C., Teesson, M., Haber, P. (2016). Is Specialized Integrated Treatment for Comorbid Anxiety, Depression and Alcohol Dependence Better than Treatment as Usual in a Public Hospital Setting? Alcohol and Alcoholism, 51(4), 402-409.
  44. Morley, K., Logge, W., Pearson, S., Baillie, A., Haber, P. (2016). National trends in alcohol pharmacotherapy: findings from an Australian claims database. Drug and Alcohol Dependence, 166, 254-257.
  45. Myers, C., Sheynin, J., Balsdon, T., Luzardo, A., Beck, K., Hogarth, L., Haber, P., Moustafa, A. (2016). Probabilistic reward- and punishment-based learning in opioid addiction: Experimental and computational data. Behavioural Brain Research, 296, 240-248.
  46. Noble, N., Paul, C., Sanson-Fisher, R., Turon, H., Turner, N., Conigrave, K. (2016). Ready, set, go: A cross-sectional survey to understand priorities and preferences for multiple health behaviour change in a highly disadvantaged group. BMC Health Services Research, 16(1), 1-11.
  47. Portelli M, White B, Wand T, Haber PS, Glozier N (2016). 'Nurse specialling': Direct nursing observation in the emergency department compared to other wards of an urban teaching hospital in Sydney. Australasian Psychiatry, Jan 28
  48. Schaffer, A., Buckley, N., Cairns, R., Pearson, S. (2016). Interrupted time series analysis of the effect of rescheduling alprazolam in Australia: Taking control of prescription drug use. JAMA Internal Medicine, 176(8), 1223-1225.
  49. Schaffer, A., Pearson, S., Buckley, N. (2016). How does prescribing for antihypertensive products stack up against guideline recommendations? An Australian population-based study (2006-2014). British Journal of Clinical Pharmacology, 82(4), 1134-1145.
  50. Sheynin, J., Moustafa, A., Beck, K., Servatius, R., Casbolt, P., Haber, P., Elsayed, M., Hogarth, L., Myers, C. (2016). Exaggerated acquisition and resistance to extinction of avoidance behavior in treated heroin-dependent men. Journal of Clinical Psychiatry, 77(3), 386-394.
  51. Shihana F, Dawson AH, Buckley NA (2016). Lessons from the field - A bedside test for methemoglobinemia, Sri Lanka. Bulletin of the WHO, 94(8):622-5.
  52. Shihana, F., Dawson, A., Dobbins, T., Dissanayake, D., Buckley, N. (2016). A bedside test for methaemoglobinemia improved antidote use in propanil poisoning. Clinical Toxicology, 54(7), 576-580.
  53. Silva, A., Johnston, C., Kuruppu, S., Kneisz, D., Maduwage, K., Kleifeld, O., Smith, I., Siribaddana, S., Buckley, N., Hodgson, W., et al (2016). Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming. PLoS Neglected Tropical Diseases, 10(12), 1-18.
  54. Silva, A., Maduwage, K., Sedgwick, M., Pilapitiya, S., Weerawansa, P., Dahanayaka, N., Buckley, N., Johnston, C., Siribaddana, S., Isbister, G. (2016). Neuromuscular Effects of Common Krait (Bungarus caeruleus) Envenoming in Sri Lanka. PLoS Neglected Tropical Diseases, 10(2), 1-18.
  55. Silva, A., Maduwage, K., Sedgwick, M., Pilapitiya, S., Weerawansa, P., Dahanayaka, N., Buckley, N., Siribaddana, S., Isbister, G. (2016). Neurotoxicity in Russell's viper (Daboia russelii) envenoming in Sri Lanka: a clinical and neurophysiological study. Clinical Toxicology, 54(5), 411-419.
  56. Sivam, S., 0Al-Hindawi, Y., Di Michiel, J., Moriarty, C., Spratt, P., Jansz, P., Malouf, M., Plit, M., Pleass, H., Havryk, A., Bowen, D., Haber, P., Bye, P., et al (2016). Liver and lung transplantation in cystic fibrosis: an adult cystic fibrosis centre's experience. Internal Medicine Journal, 46(7), 852-854.
  57. Stirling, R., Day, C. (2016). The policy and practices of New South Wales drug treatment providers in responding to the possession of illicit substances on premises. Drug and Alcohol Review, 35(5), 644-649.
  58. White, B., Haber, P., Day, C. (2016). Community attitudes towards harm reduction services and a newly established needle and syringe automatic dispensing machine in an inner-city area of Sydney, Australia. International Journal of Drug Policy, 27, 121-126.
  59. Whyte, I., Buckley, N., Dawson, A. (2016). Calcium channel blockers. Medicine (United Kingdom), 44(3), 148-150.

Book Chapters:

Books:

  1. Buckley N (2016). Organophosphorus poisoning. BMJ Knowledge/ePoCrates (commissioned monograph). https://online.epocrates.com/u/2911852/Organophosphate+poisoning/
  2. Buckley NA, Dawson AH, Whyte IM (2016).  Hypertox. Assessment and Treatment of Poisoning.  A computerised educational text published in html and an essential text for Poisons Information Services in Australia. Also available on the Internet at "www.hypertox.com".  Latest version Hypertox 2016.
  3. Hasan Abbasi, G., Adamowicz, P., Adan, A., Agay, N., Al-Hababi, S., Altun, H., Amini, M., Andersen, M., Andreassen, C., Anthony, J., Bowen, M., Conigrave, K., Cox, S., Haber, P., Murnion, B., Ullah, M., Zoellner, H., et al (2016). Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse, (pp. 1-1108). London: Elsevier.
  4. Saunders, J., Conigrave, K., Latt, N., Nutt, D., Marshall, E., Ling, W., Higuchi, S. (2016). Addiction Medicine (Second Edition). Oxford, UK: Oxford University Press.

Book chapters:

  1. Dawson A, Buckley NA (2016).  Digoxin. Medicine - Poisonous substances. Elsevier Ltd, Singapore. 44(3):158-9.
  2. Hutchinson D, Taylor L, Rapee R, Burns L and Haber PS. Mental Health, Maternal Bonding and Parenting Stress in Women Attending a Specialist Perinatal Drug Health Service. Avid Science Publications. (Accepted book chapter, December 2016).
  3. Islam, M., Nielsen, S., McRae, I., Haber, P., Demirkol, A., Murnion, B., Wilson, H., Conigrave, K. (2016). Prescribing and Dispensing of Benzodiazepines: Implications for Dependence and Misuse. In Victor R. Preedy (Eds.), Neuropathology of Drug Addictions and Substance Misuse - Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids, (pp. 283-292). London: Academic Press.
  4. Roberts D, Buckley NA (2016).  Paraquat/Diquat poisoning in: In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA; latest version September 2016.
  5. Whyte IM, Buckley NA, Dawson A (2016). Calcium Channel Blockers. Medicine - Poisonous substances. Elsevier Ltd, Singapore. 44(3):148-150.

Presentations:
  1. Becker T, Chan B, Chiew A, Dawson A, Buckley NA. Poisons Information Centre Follow Up Project. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  2. Buckley NA. Myths and Misconceptions - Paracetamol poisoning. Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Melbourne, November 2016.
  3. Buckley NA. ACMT Education symposium - Multiple choices for multiple choices (Free internet-based Educational Software). Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  4. Buckley NA. The interactive toxic challenge. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  5. Buckley NA. Paracetamol poisoning - Why guidelines continue to still change forty years after highly effective treatments were developed. University of Ruhuna, Annual medical Sessions. November 14, 2016
  6. Buckley NA. Paracetamol poisoning - Why guidelines continue to still change forty years after highly effective treatments were developed. Hong Kong College of Emergency Medicine Sessions. October 27-29, 2016
  7. Buckley NA. Reaction and Interaction Masterclass: Review of the latest drug interactions and adverse drug reactions. Pharmaceutical Society of Australia Annual Scientific Meeting, Sydney July 2016.
  8. Buckley NA. Pharmaco-epidemiology - the search for answerable and clinically relevant questions in 'big data'. (Inaugural SLACPT oration). Sri Lanka Association of Clinical Pharmacology and Therapeutics (SLACPT), Colombo June 2016.
  9. Buckley NA. Clinical Trials - validity and quality (How to be good). Symposium - Challenges in Clinical Trials. Sri Lanka Association of Clinical Pharmacology and Therapeutics (SLACPT), Colombo June 2016
  10. Buckley NA. Evidence based expert consensus guidelines. Combining the worst aspects of evidence based and consensus methods? TAPNA meeting, Brisbane May 2016.
  11. Cairns R, Buckley NA. Increased self-poisoning in young Australians: Why, 2Ks? Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  12. Cairns R, Brown J, Buckley NA. The impact of codeine re-scheduling on misuse: a retrospective review of calls to Australia's largest poisons centre. Pharmaceutical Society of Australia Annual Scientific Meeting, Sydney July 2016.
  13. Cairns R, Brown J, Buckley NA. Eucalyptus oil poisoning - do we need Koala proof packaging? European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Madrid May 2016. Clinical Toxicology 2016;54(4):376.
  14. Cairns R, Brown J, Robinson J, Lynch AM, Wylie C, Buckley NA. A decade of Australian methotrexate dosing errors. Pharmaceutical Society of Australia Annual Scientific Meeting, Sydney July 2016.
  15. Chan BS, Gault A, Granger S, Chiew A, Buckley NA, Isbister G. Bromoxynil or MCPA - the toxic ingredient. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  16. Chan B, Chiew A, Buckley N. Cardiac glycosides: how to optimize anti-digoxin fab Fragments? Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  17. Chiew AL, Isbister GK, Page C, Buckley NA. Massive Paracetamol Overdose: An Observational Study. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Madrid May 2016. Clinical Toxicology 2016;54(4):429.
  18. Chiew AL, James LP, Letzig L, Isbister GK, Buckley NA. Paracetamol-Protein Adducts following Acute Paracetamol Overdose. European Association of Poisons Centres & Clinical Toxicology Scientific meeting, Madrid May 2016. Clinical Toxicology 2016;54(4):472.
  19. Conigrave K, Lee K, Room R, Chikritzhs T, Hayman N, Gray D, Wilkes E, Wilson S, Callinan S, Developing an iPad app to help Aboriginal and Torres Strait Islander Australians to describe their drinking, Australian Professional Society for Alcohol and other Drugs (APSAD) Conference, Sydney, October 30 - November 2, 2016.
  20. Conigrave K (Keynote speaker), New Drugs, Keeping up with Constant Change, National Indigenous Drug and Alcohol Conference, Adelaide, October 12-14, 2016.
  21. Conigrave K (Keynote speaker): Methamphetamine presentations in the Emergency Department. National Indigenous Drug and Alcohol Conference, pre-conference workshop on methamphatamines Glenelg, October 11, 2016
  22. Dawson AH, Gawarramana I, Jayamana S, Manuweera G, Buckley NA. Translational research: the effects of pesticide ban policy on poisoning epidemiology and deaths in Sri Lanka. North American Congress of Clinical Toxicology. September 2016 Boston
  23. Day C & Nithyanandam L. Improving access to effective contraception for women in drug and alcohol rehabilitation. NADA Conference, Sydney, 6-7 June 2016.
  24. Jayasinghe S, Shihana F, Buckley N, Dawson A, Wunnapuk K. Antioxidant therapy on paraquat induced pulmonary injury; quantified with human clara cell protein ELISA. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  25. Kirby KA, Osborne NJ, Buckley NA, Dawson AH. Seasonal variation in self-poisoning in ten Sri Lanka hospitals. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  26. Osborne NJ, Kirby KA, Buckley NA, Dawson AH. Changing oleander (Thevetia peruviana) poisoning patterns in Sri Lanka and novel risk factors. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  27. Osborne, NJ, Cairns R, Dawson AH, Briggs N, Buckley NA. Pesticide Ingestions in Australia 2001-2014. International Society for Environmental Epidemiology. Rome Sept 2016.
  28. Pathiraja VM, Gawarammana IB, Buckley NA, Mohamed F, Jayamanna SF, Dawson AH. Vomiting associated with acute paracetamol poisoning and treatment with paracetamol antidotes. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  29. Rahman K, Nithyandan L, Morely K, Day CA. Factors associated with completion of a 6-month residential rehabilitation service at Kathleen York House. Australian Professional Society on Alcohol and other Drugs (APSAD), Sydney, 30 October to 2 November 2016.
  30. Senarathna L, Buckley NA, Dawson AH. Changes in the population incidence of deliberate self poisoning in north western province of Sri Lanka - signs for a decline. Asia Pacific Association of Medical Toxicology (APAMT) meeting, Singapore, November 17-20 2016.
  31. P. Srivastava, R. Sehgal, S.S. Shastry, E. Huang, J. Gamble, S. Kaur, G. Ramakrishna, G. McCaughan, S.K. Sarin, N. Trehanpati, D. Seth. Natural killer cells modulate endothelial progenitor cells in alcoholic chronic liver disease patients by Increasing pro-inflammatory cytokines and chemokines. J Hepatol 2016, 23:S238, abstract THU-307.
  32. Seth D for the GenomALC Consortium. Genetic risk factors for alcoholic cirrhosis - genome-wide case control study (invited). 2016 Lifespan Collaboration Award Finalist presentation at the '2016 Lifespan Research Day', 21 July 2016, USYD, Sydney, Australia.
  33. Wijerathna PATM, Gawarammana IB, Fahim M, Dissanayaka DM, Buckley N. Early and Rapid Rise of Creatinine following ingestion of Combined Washing Powder (mixture of Potassium permanganate and Oxalic Acid) in Sri Lanka is not due to direct Nephrotoxicty. 36th Annual Meeting of the Korean Society of Nephrology, 2nd June - 5th June 2016, Seoul, South Korea. (Winner Best poster award)

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE YEARS total $$ Years
NHMRC/Centre for Research Excellence Conigrave K, Wilson S, Shakeshaft A, Hayman N, Haber P, Lee K, Ivers R, Doran C, Clifford A. A Centre for Research Excellence: Building Indigenous research capacity to find solutions to alcohol problems  $2,495,984.40 2017-2021
NHMRC/Project Grant Guastella A, Haber P, Hermens D, Morley K, Lagopolous J. Oxytocin nasal spray in the treatment of alcohol dependence  $684,000.00 2017-2019
NHMRC/Project Grant Conigrave K, Haber P, Hayman N, Dobbins T, Lee K, Ivers R, Gray D, Johnson D, Wilson S Increasing uptake of evidence-based management of unhealthy alcohol use in Aboriginal primary health care services  $2,252,322.00 2016-2019
NHMRC/Project Grant Haber P, Morley K, Teesson M, Kranzler H, Shanahan M, Trent R, Baillie A, Luquin N, Luquin N Defining the clinical role of topiramate in the treatment of alcohol dependence in Australia  $728,000.00 2016-2019
NSW Health/Research Project Support Grimison P, Haber P, Stockler M, Lintzeris N, Simes R, McGregor I, Olver I, Allsop D, Gedye C, Kirby A RCT evaluating a cannabis extract for secondary prevention of chemotherapy-induced nausea and vomiting  $2,792,269.00 2015-2021
NSW Health Translational Research Grants Haber P, Morley K, Teesson M, Baillie A, Dunlop A, Baker A, Lambkin F, Sannibale C. Improving management of comorbid mental health and substance use with an integrated approach  $677,000.00 2016-2020
NHMRC/Centre of Research  Isbister GK, Buckley NA, DeSilva HJ, Brown SG, Hodgson W, Lalloo D, de Silva A, Dawson AH, Gawarammana I, Graudins A Excellence in Translational venom and antivenom research.  $2,500,000.00 2016-2020
Cancer Institute of NSW  Ross L Focusing on the Carer: a strategy to enhance quit smoking rates among mental health consumers  $145,000.00 2016-2018
NHMRC/Project Grant Conigrave K, Lee K, Room R, Chikritzhs T, Hayman N, Gray D, Wilkes E, Wilson S, Callinan S. Better methods to collect self-report data on alcohol use behaviours from Aboriginal and Torres Strait Islander Australians.  $2,109,615.00 2015-2020
NHMRC/Program Grant Buckley NA, Isbister G, Dawson AH, Roberts M. An integrated research program in human toxicology to ensure rapid translation of results into practice and regulation.  $6,846,000.00 2014-2018
National Institutes of Health (NIH)/National Institute on Alcohol Abuse and Alcoholism (NIAAA), USA Morgan T, Seth D, Day C, Mathurin P, Haber P, Whitfield J, Seitz H, Nalpas B and the GenomALC Consortium Genetic risk factors for alcoholic cirrhosis - genome-wide case control study   USD 2,500,000  2011-2017
Australia India Strategic Research Fund (AISRF) Seth D, Gamble J, Haber P, McCaughan G (Australian team); Sarin S, Trehanpati N, Kaur S (Indian team) The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease  $300,000.00 2013-2016

Contact details for department

Head of Department: Professor Paul Haber

Department/Unit: Drug Health Services
Address:
RPA Hospital
Missenden Road
Camperdown NSW 2050
Telephone: (02) 9515 7611
Facsimile: (02) 9515 8970
Web: www.slhd.nsw.gov.au/research/
Email: bethany.white@sydney.edu.au