Our Research

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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Clinical Immunology

Our Research

Professor Britton's research focuses on the immunology of tuberculosis and the development of more effective vaccines and drugs against this major human infectious disease that causes about 9 million cases and 1.5 million deaths each year. He is is CIA on the NHMRC CRE in Tuberculosis Control undertaking research into improved methods of controlling TB through contact investigation in high burden countries. They have also identified the association of genetic variants with increased risk of tuberculosis in Vietnamese.

Research Staff

  • A/Professor Stephen Adelstein, Head of Department, Immunology RPAH
  • Professor Warwick Britton
  • Dr Roger Garsia
  • Dr Frederick J Lee

Higher Degree Students:

PhD:

  • MaiAnh Nguyen
  • Anthony Marren
  • Albert Hsieh

Masters:

  • Nicolas Urriola
  • Ellis Armitage


Publications and Presentations

Publication Details:
  1. Seneviratne MG, Grieve SM, Figtree GA, Garsia R, Celermajer DS, Adelstein S, et al. Prevalence, distribution and clinical correlates of myocardial fibrosis in systemic lupus erythematosus: a cardiac magnetic resonance study. Lupus. 2016;25(6):573-81.
  2. Anderson S, Sasson SC, Lee FJ, Cooper W, Larsen S, Garsia R. Episodic fevers and vasodilatory shock mimicking urosepsis in a patient with HIV-associated multicentric Castleman's Disease: a case report. BMC Infect Dis. 2016; 16: 53.
  3. Lee FJ, Marriott D, Bloch M, Richardson R, Mackenzie N, Carr A. Post-prandial lipid effects of raltegravir versus darunavir/ritonavir in HIV-1-infected adults commencing combination ART. J Antimicrob Chemother. 2016; 71: 1127-1129.
  4. Lee FJ, Monteiro, Baker D, Bloch M, Roth N, Finlayson R, Moore R, Hoy J, Martinez E, Carr A. Rosuvastatin vs. protease inhibitor switching for hypercholesterolaemia: a randomized trial. HIV Med. 2016; 17: 605-614.
  5. Yun J, Cai F, Lee FJ, Pichler WJ. T-cell-mediated drug hypersensitivity: immune mechanisms and their clinical relevance. Asia Pac Allergy. 2016; 6: 77-89.
  6. Stifter SA, Bhattacharyya N, Pillay R, Flórido M, Triccas JA, Britton WJ, Feng CG. (2016) Functional interplay between type I and II interferons is essential to limit influenza A virus-induced tissue inflammation. PLoS Pathogens Jan 5;12(1):e1005378.
  7. Britton WJ (2016) Leprosy, in Infectious Diseases, Cohen J, Powderley WG, Opal SM. 4th Ed. (Elsevier, London) p. 108:1-7.
  8. Parumasivam T, Chan LGY, Pang A, Quan DH, Triccas JA, Britton WJ, Chan HK. (2016) In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy. Molecular Pharmaceutics 13(3):979-89.
  9. Leung SSY, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK (2016) Production of inhalation phage powders using spray freeze drying and spray drying techniques for treatment of respiratory infections. Pharmaceutical Research. 33(6):1486-96.
  10. Parumasivam T, Chang YK, Abdelghany S, Ye TT, Britton WJ, Chan HK. (2016) Dry powder inhalable formulations for anti-tubercular therapy. Advanced Drug Delivery Reviews. (accepted May 13, 2016)
  11. Parumasivam T, Leung SSY, Quan DH, Triccas JA, Britton WJ, Chan HK. (2016) Rifapentine-Loaded PLGA Microparticles for Tuberculosis Inhaled Therapy: Preparation and in vitro Aerosol Characterization. Eur J Pharmaceutical Sciences 88:1-11.
  12. Pinto R, Nambiar JK, Leotta L, Britton WJ, Triccas JA. (2016) Influence of Phthiocerol Dimycocerosate on CD4+ T cell priming and persistence during Mycobacterium tuberculosis infection. Tuberculosis 99:25-30.
  13. Giltrap AM, Dowman LJ, Nagalingam G, , Ochoa JL, Linington RG, Britton WJ Payne RJ. (2016) Total Synthesis of Teixobactin. Organic Letters 18:2788-91.
  14. Ritz N, Casalaz D, Donath S, Tebruegge M, Dutta B, Connell TG, Robins-Browne R, Britton WJ, Hanekom WA, Curtis N. (2016) Comparable CD4 and CD8 T cell responses and cytokine release after at-birth 1 and delayed BCG immunisation in infants born in Australia. Vaccine 34:4132-9.
  15. Counoupas C, Pinto R, Nagalingam G, Hill-Cawthorne G, Feng CG, Britton WJ, Triccas JA, (2016) Mycobacterium tuberculosis Components Expressed During Chronic Infection of the Lung Contribute to Long-Term Control of Pulmonary Tuberculosis in Mice. NPJ Vaccines. 1: 16012-9
  16. Woon HG, Braun A, Li J, Smith C, Edwards J, Sierro F, Feng CG, Khanna R, Elliot M, Bell A, Hislop AD, Tangye SG, Rickinson AB, Gebhardt T, Britton WJ, Palendira U. (2016). Compartmentalisation of total and virus-specific tissue-resident memory CD8+ T cells in human lymphoid organs. PLoS Pathogens Aug 19;12(8):e1005799.
  17. Parumasivam T, Chan JGY, Pang A, Quan DH, Triccas JA, Britton WJ, Chan HK. (2016) In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. Eur J Pharmaceutics Biopharmaceutics. 107:205-14
  18. Ma CS, Wong N, Rao G, Nguyen A, Avery DT, Payne K, Torpy J, O'Young P, Deenick,E, Bustamante J, Puel A, Okada S, Kobayashi M, Martinez-Barricarte R, Elliott M, Sebnem Kilic S, El Baghdadi J, Minegishi Y, Bousfiha A, Robertson N, Hambleton S, Arkwright PD, French M, Blincoe AK, Hsu P, Campbell DE, Stormon MO, Wong M, Adelstein S, Fulcher DA, Cook MC, Stepensky P, Boztug K, Beier R, Ikincio?ullari A, Ziegler JB, Gray P, Picard C, Boisson-Dupuis S, Phan TG, Grimbacher B, Warnatz K, Holland SM, Uzel G, Casanova JL, Tangye SG. Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets. J Exp Med. 2016 Jul 25;213(8):1589-608. doi:10.1084/jem.20151467.
  19. Lee AY, Hudspeth AR, Adelstein S. The concordance of serial ANA tests in an Australian tertiary hospital pathology laboratory. Pathology. 2016 Oct;48(6):597-601. doi: 10.1016/j.pathol.2016.06.003. Epub 2016 Sep 3. PubMed PMID: 27600602.
  20. Vijayan, D., Redzwan, N., Avery, D. T., Wirasinha, R. C., Brink, R., Walters, G., Adelstein, S., Kobayashi, M., Gray, P., Elliott, M., Wong, M., King, C., Vinuesa, C. G., Ghilardi, N., Ma, C. S., Tangye, S. G., and Batten, M. (2016) IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice, The Journal of Immunology 197, 3008 - 3017
  21. Martin Seneviratne, Stuart M Grieve, Gemma A Figtree, Roger Garsia, David Celermajer, Stephen Adelstein, Rajesh Puranik (2016) Functional Correlates of Myocardial Fibrosis in SLE: a cross-sectional study using cardiac magnetic resonance ; Lupus, 25(6), 573-581.
  22. Anderson, S., Sasson, S., Lee, F., Cooper, W., Larsen, S., Garsia, R. (2016). Episodic fevers and vasodilatory shock mimicking urosepsis in a patient with HIV-associated multicentric Castleman's Disease: a case report. BMC Infectious Diseases, 16(1), 1-8.
  23. SC Sasson, S Davies, R Chan, L Davies, R Garsia (2016) Cerebral toxoplasmosis in a patient with myasthenia gravis and thymoma with immunodeficiency/Good's syndrome: a case report BMC Infectious Diseases 16 (1), 457
  24. Castley A, Sawleshwarkar S, Varma R, Herring B, Thapa K, Dwyer DE, Chibo D, Nguyen N, Hawke K, Ratcliff R, Garsia R, Kelleher A, Nolan D: The Australian Molecular Epidemiology Network-HIV (AMEN-HIV). A national study of the molecular epidemiology of HIV-1 in Australia 2005-2012 ( PlosOne 2017)
  25. Pinto, A. Carrera, A. Salem, H. Thapa, K. Shaik, A. Petoumenos, K. Cunningham, P. Garsia, R. Dwyer, D. Cooper, D. Kelleher, A. . Evolution of HIV-1 surveillance drug resistance mutations over ten years in New South Wales, Australia. AIDS Research and Human Retroviruses. 2017
  26. Outcomes of pulmonary arterial hypertension therapy in Australia: Is monotherapy adequate?'. Moonen A, Garsia R, et al ( In press 2017 Int Med J )

Presentations:
  1. Agapides M, Wienholt L, Clancy A, Loblay R, Swain A, Adelstein A (2016) The Utility of Serum-based testing in the Diagnosis and monitoring or eosinophilic Oesophagitis (EoE) ASCIA ASM, Gold Coast, September 2016
  2. Clinical Immunology Course, International Congress of Immunology
  3. Initial ART update. The HIV Master class 2016. December 02, 2016. Melbourne, Australia.

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE TOTAL ($) YEARS
University of Sydney Equipment Grant. Britton W, Semsarian C, Brilot-Turville F; University of Sydney Equipment Grant. Robots to expand drug discovery, neurology and cardiovascular research;  $10,000 2016
NHMRC Project Grant  Triccas JA, Petrovsky N, Britton WJ. NHMRC Project Grant APP1102597 Multistage vaccines for the prevention of tuberculosis. $884,290 2016-19
RL Cooper Medical Research . Foundation.  Britton WJ, Florido M, Siero F, Palendira M. RL Cooper Medical Research . Foundation. Imaging Mycobacterium tuberculosis-specific tissue resident memory T cells in the lung.   $25,000 2016
NHMRC Project Grant 1044343.  Payne R, Britton WJ, Crick D.West NP, Charman S. NHMRC Project Grant 1044343. Discovery of new tuberculosis drug leads targeting cell wall biosynthesis. $695,228 2015-17

Contact details for department

Head of Department: Associate Professor Stephen Adelstein

Department/Unit: Clinical Immunology
Address:
RPA Hospital
Missenden Road
Camperdown NSW 2050
Telephone: (02) 9515 7585
Facsimile: (02) 9515 9610
Web: www.slhd.nsw.gov.au/research/
Email: dolly.shukla@health.nsw.gov.au