Our Research

Our Research

>> Research Departments
>> Find Clinical Trials
>> Our Publications
>> Our Research Collaborations


Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

Online Feedback

Women and Babies / Obstetrics and Midwifery

Our Research

The obstetric and midwifery team at RPA are active participants in a number of research projects been driven both locally, nationally and internationally to improve pregnancy outcomes for mothers and babies. The team focus on clinical and translational research in the prediction and prevention of adverse obstetric outcomes (pre-eclampsia, intrauterine growth restriction, preterm delivery, MCDA twin pregnancies and failure to progress in labour) through screening antenatally.

We work closely with our neonatal colleagues to improve our understanding, detection and prevention of causes of stillbirth and neonatal death. We are involved in some innovative research looking at non-invasive methods of data collection during labour and are near to completing a major NHMRC trial (the POP-Out trial) looking at the impact of active management of malposition in labour.

Key Achievements

  • 16 journal articles published during the year.
  • 50 presentations were made by staff during the year.
  • Total funding received- $15,000

Awards/Medals

  • Dr Farmey Joseph - 2016 RPAH Medical Officers' Association Patron's Prize for Clinical Research (young investigator award)
  • Ms Arlene D'Silva: Defining post-translational modifications in first trimester serum from women who develop preterm labour. Cerebral Palsy Alliance: Grant award $15,000.

Research Staff

  • Clinical Professor Jon Hyett: Obstetrician and lead investigator in first trimester predictive modelling.
  • Associate Professor Kirsten Black: Obstetrician/Gynaecologist leading early pregnancy and international women's health research.
  • Dr Rina Fyfe: Maternal Fetal Medicine Fellow and co-investigator of universal umbilical cord blood gases.
  • Dr Bradley De Vries: Obstetrician/Gynaecologist and lead investigator on the POP-OUT Trial.
  • Dr Joanne Ludlow: Obstetrician/Gynaecologist and lead investigator for early pregnancy / endometriosis based research.
  • Dr Adam Mackie: Obstetrician/Gynaecologist and investigator in labour ward management.
  • Dr Ritu Mogra: Obstetric/Gynaecological Sonologist and investigator into structural and functional fetal cardiac anomalies.
  • Dr Robert Ogle: Obstetrician/Head of Department and investigator in hypertensive disease in pregnancy.
  • Dr Hala Phipps: Clinical Research Midwifery Consultant for RPA and SLHD: Key investigator of POP-OUT Trial and co-ordinating midwifery research.
  • Dr Jane Tooher: Research midwife co-ordinating departmental research
  • Lucy McCudden: Research midwife of universal umbilical cord blood gases.
  • Peter Melville: Research midwife and of universal umbilical cord blood gases.
  • Stan Santiagu: senior Obstetrics and Gynaecology registrar and investigating issues relating to caesarean section.
  • Karen Burkner: Research midwife for 2 multi-centred trials- CIPS and APPROVE Trials
  • Tara Reilly: Research midwife for follow-ups POP-OUT Trial
  • Susanne Holmes: Research midwife for 1 multi-centred trial - CIPS trial.

Higher Degree Students:

PhD:

  • Dr Felicity Park: First trimester prediction and prevention of pre-eclampsia.
  • Dr Bradley de Vries (obstetrician): Prediction and prevention of intrapartum caesarean section'.
  • Ms Sarah Smith (Engineer): "Quantification of forces exerted through labour on the mother and the fetus".
  • Mrs Kate Cheney (Clinical Midwifery Consultant)  PhD Candidate: "the relationship between pregnancy intention and maternal overweight"
  • Mrs Kate  Russo  (sonographer): PhD Candidate: "Maternal cardiac function in preeclampsia"
  • Mrs Tracey Taylor (sonographer): PhD candidate: Sonographic features of miscarriage and adverse obstetric outcome before 12 weeks gestation. 
  • Madeline Simpson (Midwifery): PhD Candidate: "Understanding the development of posttraumatic stress disorder following childbirth and its impact on women who access residential parenting services in NSW" 
  • Ms Arlene D'Silva. PhD Candidate: Proteomic changes in first trimester serum prior to preterm delivery.  
  • Ms Loretta Musgrove (Midwifery): PhD Candidate: "Evaluation of Baby Buddy Australia mobile app on positive behavior changes in pregnant women from vulnerable populations

Masters:

  • Luisa Olaya: Cell free fetal miRNA expression in relation to fetal anomalies. 


Publications and Presentations

Publication Details:
  1. McMaster-Fay, R., Hyett, J. (2016). Cell-free fetal DNA in the pathogenesis of pre-eclampsia. American Journal of Obstetrics& Gynecology, 214(4), 548-548.
  2. Hyett, J. (2016). Combined first trimester or cffDNA screening, BJOG, 123(1), 98-98
  3. Yaron, Y., Hyett, J., Langlois, S. (2016). Current controversies in prenatal diagnosis 2: for those women screened by NIPT using cell free DNA, maternal serum markers are obsolete. Prenatal diagnosis, 36(13), 1167-1171
  4. Pedersen, L., Mogra Mishra, R., Hyett, J. (2016). Effect of corticosteroids on cardiac function in growth-restricted fetuses. Ultrasound in Obstetrics and Gynecology, 48(2), 204-209.
  5. Sweeting, A., Ross, G., Hyett, J., Molyneaux, L., Constantino, M., Harding, A., Wong, J. (2016). Gestational Diabetes Mellitus in Early Pregnancy: Evidence for Poor Pregnancy Outcomes Despite Treatment. Diabetes Care, 39(1), 75-81.
  6. Mogra Mishra, R., Kesby, G., Sholler, G., Hyett, J. (2016). Identification and management of fetal isolated right sided aortic arch in an unselected population. Ultrasound in Obstetrics and Gynecology, 48(6), 739-743
  7. Andraweera, P., Bobek, G., Bowen, C., Burton, G., Correa Frigerio, P., Chaparro, A., Dickinson, H., Duncombe, G., Hyett,J., et al (2016). IFPA meeting 2015 workshop report: Mechanistic role of the placenta in fetal programming; biomarkers of placental function and complications of pregnancy; late onset fetal growth restriction surveillance and monitoring. Placenta, 48(Suppl. 1), S7-S11.
  8. De Vries, B., Bryce, B., Zandanova, T., Ting, J., Kelly, P.,Phipps, H., Hyett, J. (2016). Is neonatal head circumference related to caesarean section for failure to progress? Australian and New Zealand Journal of Obstetrics and Gynaecology, 56(6), 571-577.
  9. Christiansen, M., Ekelund, C., Petersen, O., Hyett, J., Eastwood, N., Ball, S., Tabor, A., Vogel, I. (2016). Nuchal translucency distributions for different chromosomal anomalies in a large unselected population cohort. Prenatal diagnosis, 36(1), 49-55.
  10. Park, F., Russo, K., Williams, P., Pelosi, M., Puddephatt, R.,Walter, M., Leung, B., Saaid, R., Rawashdeh, H., Ogle, R.,Hyett, J. (2016). Prediction and Prevention of Early-Onset Preeclampsia: Impact of Aspirin after First-Trimester Screening. Obstetrical and Gynecological Survey, 71(1), 11-13.
  11. Chen, Q., Wang, Y., Zhao, M., Hyett, J., da Silva Costa, F.,Nie, G. (2016). Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases. Cytokine, 83, 226-230.
  12. Nicholls, D., Sweet, L., Muller, A., Hyett, J. (2016). Teaching psychomotor skills in the twenty-first century: Revisiting and reviewing instructional approaches through the lens of contemporary literature. Medical Teacher, 38(10), 1056-1063.
  13. Maia e Holanda Moura, S., Park, F., Murthi, P., Martins, W., Kane, S., Williams, P., Hyett, J., Da Silva Costa, F. (2016).TNF-R1 as a first trimester marker for prediction of preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine, 29(6), 897-903.
  14. Marren, A., Tan, Y., De Vries, B., Ng, C., Livingstone, M., Bowman, M. (2016). Use of the CryoPredict algorithm to predict live birth from cryopreserved embryos. Australian and New Zealand Journal of Obstetrics and Gynaecology, 56(3),260-266.
  15. Tooher, J., Thornton, C., Makris, A., Ogle, R., Korda, A., Horvath, J., & Hennessy, A. (2016). Hypertension in pregnancy and long-term cardiovascular mortality: a retrospective cohort study. American journal of obstetrics and gynecology, 214(6), 722. e721-722. e726
  16. Cheney K, Sim KA, D'souza M, Pelosi M, Black KI. (2016) Unintended pregnancy amongst an early pregnancy clinic cohort: identifying opportunities for preventative health interventions. Australian & New Zealand Journal of Obstetrics and Gynaecology.

Presentations:

Conference Presentations/Posters International:

  1. Fyfe R. The effect of Mifepristone on the length of labour, in the setting of termination of pregnancy >20 weeks. 15th World Congress in Fetal Medicine, 26-30 June 2016, Palma de Mallorca, Spain
  2. Hyett J. Hong Kong College of Obstetrics and Gynaecology. Plenary Lecture: Prediction and prevention of pre-eclampsia. Hong Kong. 6 March 2016.
  3. Hyett J. ISUOG First trimester Education Course. Plenary lectures: early diagnosis of fetal anomalies. How early is feasible? Anomalies of the genitourinary tract. London UK 13 March 2016.
  4. Hyett J. Controversies in Obstetrics and Gynaecology International (COGI). Plenary lectures: Amniocentesis to define a fetal inflammatory response in premature rupture of membranes (PPRoM) and spontaneous preterm labour. Screening in pregnancy: Traditional screening for aneuploidy and prediction of preeclampsia. Debate: There is no place for tocolysis in threatened preterm labour. Melbourne Australia 21-23 March 2016.
  5. Hyett J. SOGC West/Central Regions Annual Meeting. Plenary lectures: First trimester prediction of preeclampsia. Predicting, preventing and managing preterm delivery. Debate: Universal cervical length screening for prevention of preterm birth. Banff Canada. 1 April 2016.
  6. Hyett J. Argentinean Perinatal Society. Plenary lectures: NIPT in clinical practice. First trimester ultrasound in the era of NIPT. Prediction of gestational diabetes at 11-13 weeks pregnancy. Selective reduction in monochorionic twin pregnancies. Cordoba, Argentina 21-23 April 2016.
  7. Hyett J. International Society of Prenatal Diagnosis. Pre-congress courses: Prenatal screening in the era of cell-free DNA analysis. Shades of Gray - helping patients navigate the uncertainties of prenatal testing. Main meeting /Plenary debate: First trimester biochemical markers are obsolete in the era of NIPT. Berlin, Germany. 10-13 July.
  8. Hyett J. Diabetes in Pregnancy Asia Pacific Meeting. Plenary lectures: First trimester prediction and prevention of pre-eclampsia. First trimester prediction and prevention of gestational diabetes. Colombo, Sri Lanka. 8-10 September.
  9. Hyett J. ISUOG Main Scientific Meeting. Session chair: First trimester screening. Debate: All karyotypic analysis should involve a prenatal microarray. Rome, Italy. 24-28 September.
  10. Hyett J. Asia Pacific Congress in Maternal and Fetal Medicine. Pre-congress course speaker: Non-invasive prenatal testing of aneuploidies. Plenary lectures: The impact of in utero therapy on perinatal mortality and morbidity. Intergrowth charts: Does one standard fit all? Aspirin prophylaxis: Optimal timing and dosage? Penang, Malaysia. 6-9 October.
  11. Hyett J. Colombian Annual Maternal and Fetal Medicine Society Meeting. 17-21 November.

National:

  1. Phipp H, Shelley R,Dietz P. what if we could predict delivery mode: exploring women'sViews. Sydney International Update on Advances in Perinatal Care. 4th-6th August 2016, Novotal Hotel, Sydney Olympic Park.
  2. Prenatal cardiac screening: A two day course for sonographers and sonologists. Course organiser Dr Ritu Mogra. The Charles Perkins Centre Auditorium | RPA and University of Sydney. 20-21 February 2016. [300 attendees]
  3. Hyett J. Mercy Perinatal Scientific Conference. Hot topics in first trimester ultrasound. Melbourne 1-3 December

District:

  1. Phipps H. Posterior and transverse positions in labour: should we turn baby around? RPA Midwifery conference- working with complexity in maternity care (Invited Speaker). Kerry Packer Education Centre Auditorium, Royal Prince Alfred Hospital, 23rd September 2016
  2. Tooher J. Hypertension in Pregnancy - the presence and the long term risks. RPA Midwifery conference- working with complexity in maternity care (Invited Speaker). Kerry Packer Education Centre Auditorium, Royal Prince Alfred Hospital, 23rd September 2016
  3. Cunningham L, Phipps L. Literature review: Comparing effectiveness of two Group B Streptococcal screening methods in term pregnancies. SLHD Nursing and Midwifery Research Symposium 2016- Celebrating our research achievements. Concord Hospital Education Centre, 23 November 2016.
  4. Dunphy C Setting up Midwifery group practice at Canterbury Hospital Women and Babies: RPA Midwifery conference- working with complexity in maternity care (invited speaker). Kerry Packer Education Centre Auditorium, Royal Prince Alfred Hospital, 23rd September 2016.
  5. Dunphy C, Griew K, Fairbrother G. Building Group practice at Canterbury Hospital Maternity: SLHD Nursing and Midwifery Research Symposium 2016- Celebrating our research achievements. Concord Hospital Education Centre, 23 November 2016.
  6. Cheney K. Pregnancy intention and socio-demographic characteristics in obese and non-obese women, attending antenatal clinics: A cross- sectional analysis. Kerry Packer Education Centre Auditorium, Royal Prince Alfred Hospital, 23rd September 2016.
  7. Simpson M, Catling C. Understanding psychological traumatic birth experiences: A literature review. Women Birth. 2016 Jun; 29(3): 203-207.
  8. Burton A, O'Loughlin T. Induction of labour pathways. Maternity Audit. Parent Education Centre, RPA Hospital, 1-3pm, 28th July 2016.
  9. Hyett J, Innell M. BMI screening in antenatal care. Maternity Audit. Parent Education Centre, RPA Hospital, 1-3pm, 28th July 2016.
  10. De Vries B, Ramachandran A. External Cephalic Version. Parent Education Centre, RPA Hospital, 1-3pm, 16th November 2016.
  11. De Vries, Campbel N, Wu J, Holmes S. Vaginal birth after caesarean section rates at RPA. Parent Education Centre, RPA Hospital, 1-3pm, 16th November 2016.
  12. Htum S, Phua C, Child J. Vaginal birth after caesarean section rates at Canterbury Hospital. Parent Education Centre, RPA Hospital, 1-3pm, 16th November 2016.
  13. Davies G. FGM: Obstetric and neonatal outcomes at Canterbury Hospital. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  14. Cohen S. Developing a database on endometriosis. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016
  15. Buckley V. Cost analysis of treatment options in EPAS. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  16. Duncan R. Is medical management of miscarriage cost effective compared to surgical or expectant management? RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016
  17. Jellins J. Assessing the suitability and effectiveness of follow-up after stillbirth and neonatal death. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  18. Joseph F. A new method of developing birth weight reference charts. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  19. Woo J. Assessing the risk of preterm birth by cervical elastography. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  20. Taylor B. Short birth interval: choice or circumstance? RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  21. El-Adchi V. The effect of aspirin on the prevalence of PPROM. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  22. Cong A. Outcome of subsequent pregnancies in women who have had a previous emergency Caesarean Section at full dilatation. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  23. Lim V. Population values of umbilical cord gas at RPAH. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  24. Fyfe R, McCudden L, Melville P. Umbilical Cord Blood Leptin Study. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  25. Strocky S. Robotic surgery in benign gynaecology. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  26. Burton A. neonatal body fat composition at RPA. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  27. Li Y. Preliminary outcomes of new surgical training programme. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  28. Eames A. Defining occipitoposterior with maternal and neonatal outcomes. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  29. Mylvaganam G. Women's views regarding contraception. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  30. Yang J. Women's perspectives on interpregnancy intervals. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  31. Ferris L. Monochorionic diamniotic (MCDA) twin pregnancy - mode and timing of delivery. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  32. Arora H. Value added prolapse surgery:salpingectomy at the time of vaginal hysterectomy to reduce ovarian cancer risk. RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016
  33. Brazel C. Does surgical management of first trimester miscarriage increase the risk of subsequent preterm birth? RPA Women and Babies Registrar / RMO, Research Presentation Day, KPEC Large conference room 4.2, 16th Dec 2016.
  34. Cheney K. Obesity & Conception: Short and long term consequences at the Getting Healthy before Pregnancy Conference (Invited Speaker), Charles Perkins Centre, Sydney Australia, August 2016.
  35. Cheney K. Maintaining safety - a shared responsibility. Australian College of Midwives - NSW Branch Inc, Annual State Conference July 2016, Leura, Australia.
  36. Cheney K. How well do normal weight, overweight and obese Australian women plan their pregnancy. SLHD Nursing and Midwifery Research Symposium 2016- Celebrating our research achievements. Concord Hospital Education Centre, 23 November 2016.

Research Grants

GRANTING BODY AWARDEES PROJECT TITLE YEARS total $$ Years
Cerebral Palsy Alliance Ms Arlene D'Silva Defining post-translational modifications in first trimester serum from women who develop preterm labour.   $15,000.00 2016-

Contact details for department

Head of Department: Dr Robert Ogle

Department/Unit: Women and Babies / Obstetrics and Midwifery
Address:
RPA Hospital
Missenden Road
Camperdown NSW 2050
Telephone: (02) 9515 8887
Facsimile: (02) 9515 3811
Web: http://www.slhd.nsw.gov.au/research/
Email: Hala.Phipps@health.nsw.gov.au