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Contact Details

  Street address:
Level 11, KGV Building
Missenden Road
CAMPERDOWN NSW 2050
 
Postal address:
Post Office Box M30
Missenden Road NSW 2050

Phone: (02) 9515-6111
Fax: (02) 9515-9610

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Sexual Health

Sexual Health

Our Research

Sydney Local Health District (SLHD) has the highest rates of gonorrhoea, infectious syphilis and newly diagnosed HIV in NSW, and the highest rate of chlamydia in metropolitan NSW. SLHD Sexual Health Service (comprising a clinical and a health promotion service) aims to reduce the high rates of these sexually transmitted infections (STIs) in our local community, and improve the health of individuals and communities living with, or at risk of, STIs, including HIV. A key component of our work is research and evaluation to inform health promotion activities and clinical service provision.

We are involved in a number of projects which monitor patterns of STIs, including HIV, throughout Australia. This research has led to a greater understanding of who is at highest risk of STIs and HIV and the reasons for this, allowing us to better target and plan education, prevention and clinical services for the residents of SLHD. We are also involved in several large collaborative studies with other centres throughout Australia and internationally to investigate and improve the sexual health and wellbeing of high-risk groups and people living with HIV.These include:

  • The Study of the Prevention of Anal Cancer: a study of anal precancerous lesions in gay men which we hope will inform an anal cancer screening program, in an effort to address increasing rates of anal cancer in Australia
  • A study of cognitive impairment among individuals living with HIV in a effort to better identify and assist those who have mild levels of impairment related to HIV
  • The ACCESS study: investigating rates and risk factors for a broad range of STIs among Australians attending sexual health clinics and other clinical services
  • The Opposites Attract Study: investigating the risk of HIV transmission from an HIV-positive gay man to his HIV-negative partner
  • Australian Positives and Peers Longitudinal Evaluation Study (APPLES) is comparing lifestyle and behavioural factors between older HIV-positive and HIV-negative men to investigate why HIV-positive gay men appear to be suffering common age-related illnesses, such as cardiovascular disease, at a younger age
  • The Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) Study: investigating the impact that earlier treatment of HIV-positive individuals has on reducing the risk of HIV transmission in Australia
  • The PRELUDE and EPIC-NSW studies are investigating the use of HIV medications by high-risk HIV-negative individuals to reduce their risk of acquiring HIV
  • The Mouthwash in Australia Survey (MARS) and the Oral Mouthwash use to Eradicate GonorrhoeA (OMEGA) studies: the first RCT to evaluate whether daily use of mouthwash could reduce the risk of pharyngeal gonorrhoea acquisition
  • Treatment efficacy of azithromycin 1g single dose versus doxycycline 100mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial: the first RCT to compare treatment efficacy of azithromycin versus doxycycline for the treatment of rectal chlamydia in men who have sex with men
  • Improving medical follow-up of sexual assault victims: a study investigating whether active referral to RPA Sexual Health improves attendance rates for medical follow-up among those recently sexually assaulted, and factors associated with non-attendance

Key Achievements

The following are our current, ongoing collaborative studies with the Kirby Institute at UNSW Australia and other research centres nationally and internationally:

  • Australian HIV Observational Database (AHOD): A/Prof Templeton, Principle Site Investigator
  • Australian Chlamydia Collaborative Enhanced Sentinel Surveillance (ACCESS): A/Prof O'Connor, Principle Site Investigator
  • Study for the Prevention of Anal Cancer (SPANC): A/Prof Templeton, Chief Investigator and Principle Site Investigator
  • Treatment with Antiretrovirals and Impacts on Positive And Negative men (TAIPAN): A/Prof Templeton, Chief Investigator
  • PRELUDE HIV Pre-exposure prophylaxis demonstration project: A/Prof Templeton, Chief Investigator and Principle Site Investigator
  • EPIC-NSW : HIV Pre-exposure prophylaxis project: A/Prof O'Connor, Principle Site Investigator
  • Australian Positive and Peers Longitudinal Evaluation Study (APPLES): A/Prof Templeton, Principle Site Investigator
  • The Mouthwash in Australia Survey (MARS) and the Oral Mouthwash use to Eradicate GonorrhoeA (OMEGA) studies: A/Prof Templeton, Principle Site Investigator
  • Treatment efficacy of azithromycin 1g single dose versus doxycycline 100mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial: A/Prof Templeton, Principle Site Investigator
  • Improving medical follow-up of sexual assault victims: a study investigating whether active referral to RPA Sexual Health improves attendance rates for medical follow-up among those recently sexually assaulted, and factors associated with non-attendance: Ms Loretta Healey, Chief Investigator
  • A/Prof Templeton Chair, Australian HIV Observational Database Steering Committee
  • A/Prof Templeton: Scientific Program Chair of Australasian Sexual Health Conference 2016
  • A/Prof Templeton: Member, Core National Program Committee, Australasian HIV/AIDS Conference 2016
  • A/Prof O'Connor: Member, Steering Committee, ACCESS study
  • A/Prof Templeton: Invited speaker, 14th Social Research Conference on HIV, Viral Hepatitis and Related Diseases 2016
  • A/Prof Templeton: Invited speaker, Australasian Sexual Health and HIV Conference, Adelaide Sydney Local Health District Quality Awards, Highly Commended, Collaborative Team Category Improving medical follow-up among victims of sexual assault (Healey L, Hatten B, Templeton DJ)

Research Staff

  • A/Prof David Templeton (Head of Research)
  • A/Prof Catherine O'Connor
  • Ms Loretta Healey
  • Ms Linda Garton
  • Ms Barbara Hatten
  • SPANC Study Coordinator: Ms Amber Ellis
  • PRELUDE study Coordinator: Mr Gary Prott
  • EPIC study coordinators: Mr Brett Sinclair & Ms Lizzie Griggs
  • APPLES study coordinator: Mr Brett Sinclair

Higher Degree Students:

PhD:

  • Dr Sian Goddard, PhD Candidate, Kirby Institute, UNSW (A/Prof Templeton Primary Supervisor)
  • Ms Denise Cummins, PhD Candidate, University of Sydney (A/Prof O'Connor, Co-supervisor)


Publications and Presentations

Publication Details:
  1. Tilley DM , Dubedat SM, Lowe P, Templeton DJ. Genital Trichomonas vaginalis is rare among female attendees at a Sydney metropolitan sexual health clinic. Australian and New Zealand Journal of Public Health 2016;40:95-96
  2. Jin F, Grulich AE, Poynten IM, Hillman RJ, Templeton DJ, Law C, Farnsworth A, Garland SM, Fairley CK, Roberts JM, on behalf of the SPANC study team. The performance of anal cytology as a screening test for anal high-grade squamous intraepithelial lesions in homosexual men. Cancer Cytopathology 2016;123:415-24
  3. Machalek DA, Poynten IM, Jin F, Hillman RJ, Templeton DJ, Law C, Roberts J, Tabrizi SN, Garland SM, Farnsworth A, Fairley CK, Grulich AE, on behalf of the SPANC study team. A composite cytology-histology endpoint allows a more accurate diagnosis of anal high grade squamous intraepithelial lesions. Cancer Epidemiology Biomarkers and Prevention 2016;25:1134-43
  4. Templeton DJ, Ressler KA, Hope K, Poynten IM. Enhanced surveillance of a lymphogranuloma venereum outbreak in Sydney 2010-2012. Australian and New Zealand Journal of Public Health 2016;40:368-70
  5. Poynten IM, Machalek D, Templeton DJ, Jin F, Hillman R, Zablotzska I, Holt M, Grulich AE. Comparison of age-specific patterns of sexual behaviour and anal HPV prevalence in homosexual men with patterns in women. Sexually Transmitted Infections 2016;92:228-31
  6. Roberts JM, Cornall AM, Ekman D, Law C, Poynten IM, Jin F, Hillman RJ, Templeton DJ, Tabrizi SN, Garland SM, Thurloe JK, Grulich AE, Farnsworth A. Papillary immature metaplasia of the anal canal- a low-grade lesion which can mimic a high-grade lesion. American Journal of Surgical Pathology 2016;40:348-53
  7. Ong J, Grulich AE, Walker S, Hoy J, Read TR, Bradshaw C, Garland SM, Hillman R, Templeton DJ, Hocking J, Eu B, Tee BK, Fairley CK. Anal cancer screening using digital ano-rectal examination in HIV-positive men who have sex with men: baseline findings from the Anal Cancer Examination (ACE) study. Journal of Medical Screening 2016;23:70-6
  8. Roberts JM, Jin F, Ekman D, Adams MK, McDonald RL, Thurloe JK, Richards A, Poynten IM, Law C, Fairley CK, Hillman RJ, Tabrizi SN, Cornall AM, Templeton DJ, Garland SM, Grulich AE, Farnsworth A. Is there a role for the ThinPrep Imaging System in reporting anal cytology? Diagnostic Cytopathology 2016;44:384-8
  9. Mulhall BP, Wright ST, De La Mata N, Allen D, Brown K, Dickson B, Grotowski M, Jackson E, Petoumenos K, Foster R, Read T, Russell D, Smith DJ, Templeton DJ, Fairley CK, Law MG. Risk factors associated with incident sexually transmitted infections in HIV-positive patients in the Australian HIV Observational Database: a prospective cohort study. HIV Medicine 2016;17:623-30
  10. Ingleton A, Hope K, Najjar Z, Gupta L, Templeton DJ. Characteristics of cases of gonorrhoea notified in inner and south-western Sydney, Australia: results of population-based enhanced surveillance. Sexual Health (accepted Apr 2016)
  11. Machalek DA, Jin F, Poynten IM, Hillman RJ, Templeton DJ, Law C, Roberts JM, Tabrizi SN, Garland SM, Farnsworth A, Fairley CK, Grulich AE. Prevalence and risk factors associated with high-grade anal squamous intraepithelial lesions (HSIL)-AIN2 and HSIL-AIN3 in Australian homosexual men. Papillomavirus research 2016;2:97-105
  12. Molano M, Tabrizi SN, Garland SM, Roberts JM, Machalek DA, Phillips S, Chandler D, Hillman RJ, Grulich AE, Jin F, Poynten IM, Templeton DJ, Cornall AM, on behalf of the SPANC Study Team. Quantitative CpG methylation analysis of the upstream regulatory region of HPV16 in laser capture microdissected archival tissue and whole tissue sections from high grade anal squamous intraepithelial lesions. PLOS One 2016; 11: e0160673
  13. Roberts JM, Jin F, Thurloe JK, Ekman D, Adams MK, McDonald RL, Biro C, Poynten IM, Grulich AE, Farnsworth A; on behalf of the Study of the Prevention of Anal Cancer (SPANC) Study Team (Templeton DJ, Chief Investigator, SPANC). The value of a transformation zone component in anal cytology to detect HSIL. Cancer Cytopathology 2016;124:596-601
  14. Zaunders J, Danta M, Bailey M, Mak G, Marks K, Seddiki N, Xu Y, Templeton DJ, Cooper DA, Boyd MA, Kelleher AD and Koelsch KK. CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals. Frontiers in Immunology 2016; 7:438.
  15. Goddard SL, Rajagopal P, Templeton DJ. Increasing yield of pharyngeal Chlamydia trachomatis among male gay and bisexual clinic attendees in Sydney: An observational study. Sexual Health (accepted December 2016)
  16. Vaccher S, Grulich A, McAllister J, Templeton DJ, Bloch M, McNulty A, Holden J, Poynten M, Prestage G, Zablotska I. A protocol for an open-label, single-arm trial of HIV pre-exposure prophylaxis (PrEP) among people at high risk for HIV infection: The NSW Demonstration Project PRELUDE. BMJ Open 2016;6:e012179
  17. Callander D, Stoové M, Carr A, Hoy JF, Petoumenos K, Hellard M, Elliot J, Templeton DJ, Liaw ST, Wilson DP, Grulich AE, Cooper DA, Pedrana A, Donovan B, McMahon J, Prestage G, Holt M, Fairley CK, McKellar-Stewart N, Ruth S, Asselin J, Keen P, Cooper C, Allan B, Kaldor JM, Guy R. A longitudinal cohort study of HIV 'treatment as prevention' in gay, bisexual and other men who have sex with men: The Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) Study Protocol. BMC Infectious Diseases 2016;16:752
  18. Kakar S, Drak D, Amin T, Cheung J, O'Connor CC, Gracey D. Screening and management of risk factors for cardiovascular disease in HIV-positive patients attending an Australian urban sexual health clinic. Sexual Health (accepted 2016)
  19. Murray K, Cummins D, Trotter G, Batterham M, Healey L, O'Connor CC. Can patients and their caregivers help identify HIV associated Mild Neurocognitive Disorder (MND)? AIDS Care. 2016;28:221-7.
  20. Giles M, Marin-Zapata C, Petoumenos K, Wright S, Grotowski M, Broom J, Law M, O'Connor CC. How do outcomes compare between women and men living with HIV in Australia? An observational study. Sexual Health 2016;13:155-161.

Presentations:

International Conference Presentations in 2016

  1. Templeton DJ, Poynten IM, Jin F, Hillman RJ, Law C, Roberts JM, Tabrizi SN, Farnsworth A, Garland SM, Fairley CK, Grulich AE; on behalf of the SPANC Study Team.Correlates Of Larger Burden Of Anal High-Grade Squamous Intraepithelial Lesions In The Study For The Prevention Of Anal Cancer (SPANC). World IUSTI Conference, Marrakech, Morocco, May 2016 (Oral)
  2. Law C, Jin F, Templeton D, Poynten M, Grulich A, Hillman R. Factors contributing towards cohort retention in the SPANC study (Study of the Prevention of Anal Cancer). International Anal Neoplasia Society Scientific Meeting, San Francisco, US, Nov 2016 (Oral)
  3. Gray J, McNulty A, Clifton B, Price K, Lockwood J, O'Connor CC, Read P, Keen P. Peer-based service development: a structured and timed expansion of community-based HIV testing for gay men in a high-income setting. International AIDS Conference 2016, Durban South Africa (poster)
  4. McManas H, Chen M; Donovan D; O'Connor CC; Fairley CK; Lewis D; Guy R; Callander D; Vhalkis E; Russel D; Varma R; Grulich A; Petoumenos K; Boyd M; Davies S, Hellard M; Earlier initiation of antiretroviral therapy in a national cohort of people newly diagnosed with HIV attending Australian sexual health clinics. International AIDS Conference 2016, Durban South Africa (Poster)

National Conference Presentations in 2016

  1. Templeton DJ, Hatten B, Healey LM. Pro-active follow-up of victims of sexual assault: an initiative to improve medical care in inner Sydney. Australasian Sexual Health Conference, Adelaide, Nov 2016 (Oral)
  2. Rees H, Callander D, Goddard SL, Griggs E, Clifton B, Templeton DJ. Higher STI yield among asymptomatic gay men attending a community-based shop-front service compared with a fast-track sexual health clinic service. Australasian Sexual Health Conference, Adelaide, Nov 2016 (Oral)
  3. Hatten B, Healey LM, Tilley DM, Dailey B, Callander D, Templeton DJ, O'Connor CC. Initiatives to improve sex worker access to STI screening in Sydney Local Health District. Australasian Sexual Health Conference, Adelaide, Nov 2016 (Poster)
  4. Kao SC, Adam P, Varma R, Read P, Bourne C, Moreton R, Templeton DJ, on behalf of Sexually Transmissible Infections in Gay Men Action Group (STIGMA). Evaluation of 2014 Sexually Transmitted Infection (STI) and HIV Testing Guidelines for Asymptomatic Men who have Sex with Men among General Practitioners in Sydney. Australasian Sexual Health Conference, Adelaide, Nov 2016 (Poster)
  5. Poynten IM, Tabrizi SN, Jin F, Cornall AM, Phillips S, Machalek DA, Hillman RJ, Templeton DJ, Law C, Roberts J, Farnsworth A, Garland SM, Fairley CK, Grulich AE, on behalf of the SPANC research team. High incidence of anal human papillomavirus (HPV) infection suggests a role for HPV vaccination in anal cancer prevention in older gay and bisexual men (GBM). Australasian Sexual Health Conference, Adelaide, Nov 2016 (Oral)
  6. Templeton DJ, Hillman RJ, Jin F, Poynten IM, , Law C, Cornall A, Phillips S, Machalek DA, Roberts J, Farnsworth A, Garland SM, Fairley CK, Tabrizi SN, Grulich AE,on behalf of the SPANC research team. Predictors of 12-month persistent high-grade squamous intraepithelial lesions (HSIL) in a cohort of gay and bisexual men (GBM). Australasian Sexual Health Conference, Adelaide, Nov 2016 (Oral)
  7. Jin F, Roberts J, Poynten IM, Cornall A, Phillips S, Machalek DA, Ekman D, McDonald R, Hillman RJ, Templeton DJ, Law C, Farnsworth A, Garland SM, Fairley CK, Grulich AE, Tabrizi SN, on behalf of the SPANC research team. Can biomarkers help predict anal high-grade squamous intraepithelial lesions (HSIL) that are likely to persist in gay and bisexual men (GBM)? Australasian Sexual Health Conference, Adelaide, Nov 2016 (Oral)
  8. Hillman RJ, Jin F, Poynten IM, Roberts J, Farnsworth A, Templeton DJ, Grulich AE , Law CL, on behalf of the SPANC Study Team. The value of quality assurance metrics in High Resolution Anoscopy (HRA). Australasian Sexual Health Conference, Adelaide, Nov 2016 (Poster)
  9. McManus H, Callander D, Donovan B, Russell D, O'Connor CC, Davies SC, Lewis D, Hellard M, Chen M, Petoumenos K, Varma R, Cogle A, Boyd MA, Vlahakis E, Grulich AE, Pollard DJ, Fairley CK, Guy RJ, ACCESS study group. Earlier initiation of antiretroviral therapy in a national cohort of people newly diagnosed with HIV attending Australian sexual health clinics. ASHM Conference 2016 Adelaide (poster)
  10. Lovell R, Fazio A Tilley D, Bogie L, Sousa MS, McMurray R, Katter R, Nicholson-Rogers S, Lynch K, O'Connor CC. 'It's our choice' - A health promotion initiative to assist women experiencing homelessness in overcoming barriers to cervical cancer screening. . Australasian Sexual Health Conference, Adelaide 2016 (poster)
  11. Lovell R, Fazio A, Tilley D, Bogie L, Sousa MS, McMurray R, Katter R, Nicholson-Rogers S, O'Connor CC 'It's been 7 years since my last test and it was abnormal, I know I'm only cheating myself' - A health promotion initiative to help women experiencing disadvantage overcome barriers to cervical cancer screening. Australasian Sexual Health Conference 2016 Adelaide (poster)
  12. Kong M, Watchirs-Smith L, Callander D, Guy R, Ward JS, Solomon N, Menon A, Russell D, Donovan B, O'Connor CC, on behalf of the ACCESS collaboration. Gonorrhoea Positivity and Risk Factors Among Aboriginal And Non-Aboriginal Women Attending Sexual Health Clinics in Australia. . Australasian Sexual Health Conference 2016, Adelaide (oral)
  13. Pak H, Bourne C, Chomley P, Dabbhadatta J, Kao S, Magner E, McGill S, O'Connor CC, Purchas, Ross K, Roy, K, Stone A, Wong S. A major role for the Sexually Transmissible Infections in Gay Men Action Group (STIGMA) in Inner Sydney: increase access, skills and knowledge of General Practitioners (GPs). Australasian Sexual Health Conference 2016, Adelaide (poster)
  14. Kakar S, Drak D, Amin T, Cheung J, O'Connor CC, Gracey D. Screening and management practices for renal disease in the HIV-positive patient population of an inner metropolitan sexual health service. . Australasian Sexual Health Conference Adelaide, 2016 (poster)
  15. Kakar S, Drak D, Amin T, Cheung J, O'Connor CC, Gracey D. Screening and management of cardiovascular disease risk factors in HIV-positive patients. . Australasian Sexual Health Conference. Adelaide 2016 (poster)
  16. Callander D, McManus H, Wilson D, O'Connor CC, Chen M, O'Sullivan M, Grulich A, Boyd M, Guy R. Women, Those Who Inject Drugs and Younger People More Likely To Have 'Detectable' HIV Viral Loads: Data From Australian Sexual Health Clinics. ASHM Conference Adelaide Nov 2016 (poster)
  17. Sousa MS, Fazio A, Tilley D, Lovell R, Katterl R, McMurray R, Bogie L, O'Connor CC. Looking beyond 'one-size-fits-all' approach: Understanding the barriers to cervical cancer screening in women experiencing social and economic disadvantage in Australia. Australasian Sexual Health Conference Adelaide 2016 (poster)
  18. Cummins D, Crawford D, Walters D, Aggers C, O'Connor CC. Losing Part of me 14th Social Research Conference on HIV, Viral Hepatitis & Related Diseases UNSW. Sydney 2016 (oral)
  19. Cummins D, Walters D, Aggers C, O'Connor CC. Is the clinical data identifying people living with HIV at risk of HIV associated cognitive impairment? 4th Asia Pacific Global Summit & Expo on Healthcare, Brisbane July 2016 (oral)

 


Research Grants

GRANTING BODY AWARDEES PROJECT TITLE YEARS total $$ Years
The Cancer Council NSW Strategic Research Partnership Grant A/Prof Templeton (CI) Preventing morbidity and mortality from anal cancer $1,960,000 2013-2017
NSW Ministry of Health Non-government Organisations Grants Program A/Prof Templeton (CI) Implementation of HIV pre-exposure prophylaxis with antiretroviral medications among people at high risk for HIV infection: A demonstration project   $603,110 2015-2016
National Health and Medical Research Council Project Grant A/Prof Templeton (CI) HIV treatment as prevention: A longitudinal assessment of population effectiveness $757,330 2015-2018

 

Head of Research: Associate Professor David Templeton

Contact details for department

Department/Unit: Sexual Health
Address:
RPA Sexual Health, 16 Marsden Street
Camperdown NSW 2044
Telephone: (02) 9515 1200
Facsimile: (02) 9515 1220
Web: www.slhd.nsw.gov.au/research/
Email: david.templeton@health.nsw.gov.au